5CWS


Conserved Protein Domain Family
Nup54

?
pfam13874: Nup54 
Click on image for an interactive view with Cn3D
Nucleoporin complex subunit 54
This is the human Nup54 subunit of the nucleoporin complex, equivalent to Nup57 of yeast. Nup54, Nup58 and Nup62 all have similar affinities for importin-beta. It seems likely that they are the only FG-repeat nucleoporins of the central channel, and as such they would form a zone of equal affinity spanning the central channel. The diffusion of importin-beta import complexes through the central channel may be a stochastic process as the affinities are similar, whereas movement from cytoplasmic fibrils to the central channel and from the central channel to the nuclear basket would be facilitated by the subtle differences in affinity between them.
Statistics
?
PSSM-Id: 338982
View PSSM: pfam13874
Aligned: 121 rows
Threshold Bit Score: 68.7516
Threshold Setting Gi: 294953481
Created: 12-Apr-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5CWS_E         46 PNEDPKEWEEA------L-----QRKPa-pN----FIPVLCSGFPSIVARLMLQRRVITEFNNKLHQINASLDAILsRHD 109
gi 122161609   35 QNVSERKWREL------LdavggENNPd------cLWPVQYDGFEGLMRRKTEASTEIKAQEEFVQAVETATRQIMqWAN 102
gi 255547750  181 AGVSDIMWAEA------MaklegMESSdreR----LWPQLVQGFKDLSNRLKLQDEVIVSDAERLRMTQSNVKMLQrHFQ 250
gi 944259021  202 vaaSDIMWAEA------MgklecMDSAdreR----LWPQLVQGFKDLSHRLKLQDEVLVSDTDRLSMTHSNVKKLQrHFQ 271
gi 297851152  163 AAVSDIMWAEA------MsklegMDSTereR----LWPQLVQGFKDLSQRLKLQDEVLASDRDRIKTTQSNVKMLQrHLQ 232
gi 145341740  522 QNVSERKWREL------LdavggENNPd--C----LWPVQYDGFEGLIQRKTQAETEIKAQEEYIQAAATSVRQILqWAD 589
gi 672285371  134 gaallAKWRKA------S-----SRSAdpqN----CLIVPVQGVQELSARVTMVAQATELLAETLGTVAKDTERLMaRNQ 198
gi 294953481  569 HGPDQMKWQMAkdlcpaM-----LDRPdsaAqgvwAYPLPLTSVDQMVSRVADQQKLVAQAEGMMENVKVQYSNLEgYVS 643
gi 586718861  118 VGISDIMWAEA------MaklegMESSdreR----LWPQLVQGFKDLSQRLKLQDEALVSDVERLRTTQTNVKLLErHFQ 187
gi 1098428349 123 DEQIIKELNIT------K-----ERNPdpnK----CYTLPLKGFGELVMREQQQRNELENLLNDMKAVKEENLKLLeMLN 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5CWS_E        110 LDHTVRAFNARRRHAELSRRCLHLAARVQVL--RNRGY---------ALSg------DEDELKQKLQ-QIDKTLNd---- 167
gi 122161609  103 TEMTRRMQNIKNKAMEHQHRLIKVFRAINQQqmKSYADangg--atpPVSa------EEIELLNRFK-DLSKRVN----- 168
gi 255547750  251 AETLPRIERMRQKEQSLQRRLLRIMRIMEAL--EGKGYr-------mPLMk------GETELAEKLA-AITRQLKg---- 310
gi 944259021  272 ADTYPWIQRLKQQELVIQRRLLRFVRIVEAL--ENRGYr-------sPLTt------EEADLYERLV-AMLKRLKg---- 331
gi 297851152  233 ASTFPSIERLRQKEQSLQRRMLRVMRIIEGL--EGKGFr-------lPLTk------GEAELSEKLT-AITRQVKg---- 292
gi 145341740  590 TELEKRMRDVKNKNMEQQHRLIKIFRTLHQA--QLKNYadanggavpPMSa------EEIELLNDFK-ALSSRVNr---- 656
gi 672285371  199 -QMREKLDLIRQRHTSLGHEFIKVVNLIEsvfefvhvcactgahacvgvsgvrdtvcssrgqtqpasavsq--------- 268
gi 294953481  644 VTTLKELEKARLRHQQLISKLTSVTALIDTL--AQSRQ---------PQQlvggayaQAEAAYSELE-------Rr---- 701
gi 586718861  188 VDTLPWIQRMRQKEQGLQRRLLRVMRIVEALegKGFRV---------PLMk------NEAQLAEKLA-GLVKQLK----- 246
gi 1098428349 188 NKTLIRIEECKKRHQHIIHQLVHISCMLEEY--------------------------GEKHNLAQINhHLDNQLNqtlhr 241
                         170       180
                  ....*....|....*....|
5CWS_E        168 -------P--AQ-GSRLEEL 177
gi 122161609  169 -------RsaASlPRRAEAL 181
gi 255547750  311 ------sG--AElSRRVQNL 322
gi 944259021  332 -------Ps-ADlSRRVNTL 343
gi 297851152  293 -------Pg-AElSRRVQSL 304
gi 145341740  657 -------Sa-ASlPRRAEAL 668
gi 672285371      --------------------
gi 294953481  702 -------A--AVvQGRFAEA 712
gi 586718861  247 -------GagAElPRRVHNL 259
gi 1098428349 242 iqenqmrL--GVwQSIMNQI 259
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap