5CWS


Conserved Protein Domain Family
Nup54

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pfam13874: Nup54 
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Nucleoporin complex subunit 54
This is the human Nup54 subunit of the nucleoporin complex, equivalent to Nup57 of yeast. Nup54, Nup58 and Nup62 all have similar affinities for importin-beta. It seems likely that they are the only FG-repeat nucleoporins of the central channel, and as such they would form a zone of equal affinity spanning the central channel. The diffusion of importin-beta import complexes through the central channel may be a stochastic process as the affinities are similar, whereas movement from cytoplasmic fibrils to the central channel and from the central channel to the nuclear basket would be facilitated by the subtle differences in affinity between them.
Statistics
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PSSM-Id: 338982
View PSSM: pfam13874
Aligned: 121 rows
Threshold Bit Score: 68.7516
Threshold Setting Gi: 294953481
Created: 12-Apr-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5CWS_E        46 PNEDPKEWEEA------L-----QRKPa-pN----FIPVLCSGFPSIVARLMLQRRVITEFNNKLHQINASLDAILsRHD 109 Chaetomium ther...
Q01FT1        35 QNVSERKWREL------LdavggENNPd------cLWPVQYDGFEGLMRRKTEASTEIKAQEEFVQAVETATRQIMqWAN 102 Ostreococcus tauri
XP_002514932 181 AGVSDIMWAEA------MaklegMESSdreR----LWPQLVQGFKDLSNRLKLQDEVIVSDAERLRMTQSNVKMLQrHFQ 250 castor bean
KQL23278     202 vaaSDIMWAEA------MgklecMDSAdreR----LWPQLVQGFKDLSHRLKLQDEVLVSDTDRLSMTHSNVKKLQrHFQ 271 foxtail millet
XP_002893457 163 AAVSDIMWAEA------MsklegMDSTereR----LWPQLVQGFKDLSQRLKLQDEVLASDRDRIKTTQSNVKMLQrHLQ 232 Arabidopsis lyr...
XP_001415961 522 QNVSERKWREL------LdavggENNPd--C----LWPVQYDGFEGLIQRKTQAETEIKAQEEYIQAAATSVRQILqWAD 589 Ostreococcus lu...
KFG54109     134 gaallAKWRKA------S-----SRSAdpqN----CLIVPVQGVQELSARVTMVAQATELLAETLGTVAKDTERLMaRNQ 198 Toxoplasma gond...
XP_002787785 569 HGPDQMKWQMAkdlcpaM-----LDRPdsaAqgvwAYPLPLTSVDQMVSRVADQQKLVAQAEGMMENVKVQYSNLEgYVS 643 Perkinsus marin...
XP_006848429 118 VGISDIMWAEA------MaklegMESSdreR----LWPQLVQGFKDLSQRLKLQDEALVSDVERLRTTQTNVKLLErHFQ 187 Amborella trich...
OII76291     123 DEQIIKELNIT------K-----ERNPdpnK----CYTLPLKGFGELVMREQQQRNELENLLNDMKAVKEENLKLLeMLN 187 Cryptosporidium...
5CWS_E       110 LDHTVRAFNARRRHAELSRRCLHLAARVQVL--RNRGY---------ALSg------DEDELKQKLQ-QIDKTLNd---- 167 Chaetomium ther...
Q01FT1       103 TEMTRRMQNIKNKAMEHQHRLIKVFRAINQQqmKSYADangg--atpPVSa------EEIELLNRFK-DLSKRVN----- 168 Ostreococcus tauri
XP_002514932 251 AETLPRIERMRQKEQSLQRRLLRIMRIMEAL--EGKGYr-------mPLMk------GETELAEKLA-AITRQLKg---- 310 castor bean
KQL23278     272 ADTYPWIQRLKQQELVIQRRLLRFVRIVEAL--ENRGYr-------sPLTt------EEADLYERLV-AMLKRLKg---- 331 foxtail millet
XP_002893457 233 ASTFPSIERLRQKEQSLQRRMLRVMRIIEGL--EGKGFr-------lPLTk------GEAELSEKLT-AITRQVKg---- 292 Arabidopsis lyr...
XP_001415961 590 TELEKRMRDVKNKNMEQQHRLIKIFRTLHQA--QLKNYadanggavpPMSa------EEIELLNDFK-ALSSRVNr---- 656 Ostreococcus lu...
KFG54109     199 -QMREKLDLIRQRHTSLGHEFIKVVNLIEsvfefvhvcactgahacvgvsgvrdtvcssrgqtqpasavsq--------- 268 Toxoplasma gond...
XP_002787785 644 VTTLKELEKARLRHQQLISKLTSVTALIDTL--AQSRQ---------PQQlvggayaQAEAAYSELE-------Rr---- 701 Perkinsus marin...
XP_006848429 188 VDTLPWIQRMRQKEQGLQRRLLRVMRIVEALegKGFRV---------PLMk------NEAQLAEKLA-GLVKQLK----- 246 Amborella trich...
OII76291     188 NKTLIRIEECKKRHQHIIHQLVHISCMLEEY--------------------------GEKHNLAQINhHLDNQLNqtlhr 241 Cryptosporidium...
5CWS_E       168 -------P--AQ-GSRLEEL 177 Chaetomium thermophilum var. thermophilum DSM 1495
Q01FT1       169 -------RsaASlPRRAEAL 181 Ostreococcus tauri
XP_002514932 311 ------sG--AElSRRVQNL 322 castor bean
KQL23278     332 -------Ps-ADlSRRVNTL 343 foxtail millet
XP_002893457 293 -------Pg-AElSRRVQSL 304 Arabidopsis lyrata subsp. lyrata
XP_001415961 657 -------Sa-ASlPRRAEAL 668 Ostreococcus lucimarinus CCE9901
KFG54109         -------------------- Toxoplasma gondii FOU
XP_002787785 702 -------A--AVvQGRFAEA 712 Perkinsus marinus ATCC 50983
XP_006848429 247 -------GagAElPRRVHNL 259 Amborella trichopoda
OII76291     242 iqenqmrL--GVwQSIMNQI 259 Cryptosporidium andersoni
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