Conserved Protein Domain Family
Kelch_5

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pfam13854: Kelch_5 
Kelch motif
The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Drosophila ring canal kelch protein is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.
Statistics
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PSSM-Id: 338971
View PSSM: pfam13854
Aligned: 64 rows
Threshold Bit Score: 29.8586
Threshold Setting Gi: 123061316
Created: 12-Apr-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90185134   460 P-APRFRHSAVkitleT-D--S--ESVLVYGGKS--S---DGSIF--D-TWL---LW--QTHSN 504
gi 123535378 1339 PfTGRTDHTLF-----E-H--D--GKLWIIGGKG--Y---EFAVF--N-DIW---T---SVDGK 1378
gi 74685127   257 P-DGRVGASLV-----A-H--PnlDMLVLHGGSV--SnstSGSYSstS-LLA---FL--NTTTF 303
gi 290989076   45 P-SQRSQIALV-----A-CppR--HSLFCMGGVVe-----EHVVS--G-DLE---VFelDLRTG 88
gi 294877698  109 P-PSFAYHPTV-----VrVpdS--SEALFIGAVK--ApqhKEEYA--L-EVWldtVH--DKREH 157
gi 817547106  354 P-GKRSCHKMC-----T-D--G--QRLYLSGKYIptSertGEISS--S-DIW---VY--N---G 395
gi 398023433  666 P-PPLHSAAAT-----A-L--Ss-DTVLVSGGVL--L---GQDAC--NpHLW---QL--RLSTK 707
gi 309365580   54 P-RVRSGHRCF-----T-D--N--DYLYLIGGYT--HqirRGSIF--K-EIW---AM--SLATF 96
gi 309365580  289 P-QARRCHTIA-----R-R--S--TKVIMTGGIF--HrenGLDVLvhS-DVW---IF--EMTDY 333
gi 134084350  470 P-VERFRHSVIrv--tL-S--S--DYVLVYGGKT--S----NGTT--L-DTW---LL--WSKED 511
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