5ERC,5DAG,4NN2


Conserved Protein Domain Family
zf-HC5HC2H

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pfam13771: zf-HC5HC2H 
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PHD-like zinc-binding domain
The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains. The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.
Statistics
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PSSM-Id: 338937
View PSSM: pfam13771
Aligned: 102 rows
Threshold Bit Score: 51.9481
Threshold Setting Gi: 74950628
Created: 30-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5ERC_A         77 HVVCALWIPEVCFANtv-----fLEPIDSIEHIPPARWKLTCYICKQRGsGACIQCHKANCYTAFHVTCAQQAGLYMKME 151
gi 74950628  1023 HSDTLKYTQTMDNLKnqnt-nltYSQNMRYGYSKSMDEEFECIVCRLKI-GVMSCCIN--CNIKFHAYCGFFQGFQFTIQ 1098
gi 74801477    84 HYFCLLSGTNIPQNGstpa-giaGFKISDVLSSYAEYREKQCYYCRHP--SAPVECAQAGCGRRYHYICGYNNSCVTQFV 160
gi 122067969  249 HYLCLLSGTHIAQRGvgdqggilGFLIQDVKQSFQIYRNKVCYCCEQF--SAPVKCNAAGCDRYFHYICGYRKGCVTQFI 326
gi 124480369  283 HEMCGLWSQNLVFFSnle-----qcDPKNIDDEVEKSKKTKCFLCSRS--GATICCAV--CPQSFHFTCLMKSSQTGKLI 353
gi 124474401  273 HEMCGLWSQNLVFFDkqg-----qcDPNNLDEEVTKSKQTKCFLCSRP--GATVCCAV--CPVAFHFTCLMNSSQTGKLv 343
gi 124453730  183 HEMCLLWSN-RVQVDyn----tmLVDIATLIQAVQFAQAQMCRYCGSI--GASLKCNKAECHVHYHFNCLKQVRLMGLQL 255
gi 124448312  376 HDL-CVYWSSMVDCDev----kgSVDFESLCNAVRIAYDTFCYLCKRR--GATMKCNNKDCNVWIHYYCWKELDPSNQY- 447
gi 124453366  276 HDLC-VFWSSLVECDek----kgTIDFESLQEVVKISQETYCYLCKRK--GPTLKCNDENCQIWIQYYCWKKLEPSQQY- 347
gi 195163367   29 HSNCLYTSSNLVQRGgvkn-gisGFRKQDILAEVQRASKLTCFYCGRN--GAPIGCCRKTCRRSFHFSCGLENLVRYQFS 105
                          90       100
                  ....*....|....*....|...
5ERC_A        152 PvretgangtsfsVRKTAYCDIH 174
gi 74950628  1099 n------------KTISVYCNNC 1109
gi 74801477   161 -------------GEFRSYCDQH 170
gi 122067969  327 -------------GEYLSYCHEH 336
gi 124480369  354 e------------NQFKFFCDKH 364
gi 124474401  344 ------------eSQFKFFCETH 354
gi 124453730  256 Dh----------eQKFRFFCEDH 268
gi 124448312  448 Ld----------nERFRMLCHRH 460
gi 124453366  348 Ld----------nQKFRMLCYQH 360
gi 195163367  106 -------------GSYKSYCHSH 115
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