Conserved Protein Domain Family
zf-HC5HC2H

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pfam13771: zf-HC5HC2H 
PHD-like zinc-binding domain
The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains. The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.
Statistics
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Aligned: 92 rows
Threshold Bit Score: 53.8727
Threshold Setting Gi: 74950628
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFE36990            1334 HVICAIWFPEIKFGSAKD-----LEPAEGIESIPQESFKDRCKICKTENGACVSCRASTCNARFHVGCAHQAGYNMGFDi 1408 Tricho...
Q4U9A5              1023 HSDTLKYTQTMDNLKNQNtn-ltYSQNMRYGYSKSMDEEFECIVCRLKIGVMSCCIN--CNIKFHAYCGFFQGFQFTIQn 1099 Theile...
Q16R05                52 HYHCLLLTSNLVQNGDDEeg-ifGFMEEDIRNEEARIRGQKCYICKEQ-YANISCCAKKCFRTFHTVCGLKNGCLSHYV- 128  yellow...
Q7PZ79                84 HYFCLLSGTNIPQNGSTPag-iaGFKISDVLSSYAEYREKQCYYCRHP-SAPVECAQAGCGRRYHYICGYNNSCVTQFV- 160  Anophe...
Q16XD4               249 HYLCLLSGTHIAQRGVGDqggilGFLIQDVKQSFQIYRNKVCYCCEQF-SAPVKCNAAGCDRYFHYICGYRKGCVTQFI- 326  yellow...
WGS:AAQB:GK19966-PA   34 HYFCLLLSTNLHQRGSDTag-ilGFLLKDIRREIAAAKQRKCVYCLEN-GASINCCK--CGKCFHLVCGIEQHVLSEFC- 108  Drosop...
EDW30988               9 HYFCLLLSTDLPQRGGDSsg-ilGFLLRDIRKEAVAAKKHKCVYCHEK-GASIACHK--CHTRFHLDCSLSNRCTSEFC- 83   Drosop...
EDW52436              34 HYFCLLLSTHLPQRGGDSsg-ilGFLLRDIREEAAAAEKRKCWYCNKI-GASLQCDR--CRTLFHLKCGLENRAVFEFC- 108  Drosop...
WGS:AANI:GJ16710-PA   34 HYYCLLLSTNLPQRGGDSsg-ilGFLLRDIRQEAAAAQQRKCAFCKER-GASVVCYK--CRIVFHMPCGLENRCIYQFC- 108  Drosop...
WGS:AAPP:GF16590-PA   33 HYFCLLLSTKLPQRGDDSvg-ilGFLLTDIRKEIAQARHRKCEYCSKM-GANVSCHK--CGDLFHMPCAVTNRCTIEFC- 107  Drosop...
EFE36990            1409 tpvkssRkdvvstatmgeetgvvAPAIWCPHH 1440 Trichophyton benhamiae CBS 112371
Q4U9A5              1100 ------K----------------TISVYCNNC 1109 Theileria annulata
Q16R05               129 ------D----------------TFQSWCDKH 138  yellow fever mosquito
Q7PZ79               161 ------G----------------EFRSYCDQH 170  Anopheles gambiae str. PEST
Q16XD4               327 ------G----------------EYLSYCHEH 336  yellow fever mosquito
WGS:AAQB:GK19966-PA  109 ------H----------------GFQSYCGEC 118  Drosophila willistoni
EDW30988              84 ------G----------------DFRSYCDAC 93   Drosophila persimilis
EDW52436             109 ------G----------------QYKSYCYKC 118  Drosophila sechellia
WGS:AANI:GJ16710-PA  109 ------D----------------EFRSYCEHC 118  Drosophila virilis
WGS:AAPP:GF16590-PA  108 ------G----------------NFISYCDTC 117  Drosophila ananassae
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