Conserved Protein Domain Family
PEP_mutase

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pfam13714: PEP_mutase 
Phosphoenolpyruvate phosphomutase
This domain includes the enzyme Phosphoenolpyruvate phosphomutase (EC:5.4.2.9). This protein has been characterized as catalyzing the formation of a carbon-phosphorus bond by converting phosphoenolpyruvate (PEP) to phosphonopyruvate (P-Pyr). This enzyme has a TIM barrel fold.
Statistics
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Aligned: 82 rows
Threshold Bit Score: 158.116
Threshold Setting Gi: 218718213
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EED17633          5 IKSvLKKN-Qd---RV----------------------------------------RLLEAHDHATKEAVRLTFsdn--- 37  Talaromyces ...
EEU42669        391 IRAaFKAR-Q----LIhpcphlyqhqpqsssiniamsatqskvdilrerlntakpaIAMAAHSPLGAKLVEEAG------ 459 [Nectria] ha...
EER17486         22 LRQlINTK-ApndgVI----------------------------------------RAMEAHSGLSAMIVEQTRahrpdg 60  Perkinsus ma...
jgi:DaAHT2_1860 153 LRRlIDAK-P----MV----------------------------------------RLMEAHNGLTGLIVENLFeqqeg- 186 Desulfurivib...
vbi:Arad_7864    15 LRAlLEKR-T----FL----------------------------------------RFLDIHNALSALIVEHTIveten- 48  Agrobacteriu...
CBL17290          6 LGSlLKNG-A----PL----------------------------------------RILEAVNGLEAYVAEHAFapdseg 40  Ruminococcus...
Q12Q29           14 LKDiLLSP-T----TE----------------------------------------YLMEAHNAISAKIIEEVG------ 42  Shewanella d...
Q4DNR3           14 LKSmLRSK-E----LS----------------------------------------FLMEAHNGLSARIVEETG------ 42  Trypanosoma ...
Q98AR7           14 lRR-MIASsE----LA----------------------------------------FAMEAHDGLSAAIAERAG------ 42  Mesorhizobiu...
WP_006773500      4 ptlqsvlaeG----QL----------------------------------------IAPDTFDGISTRAAEYMG------ 33  Hungatella h...
EED17633         38 -gesFDG-IWLSGLTQTTYLGIPDTELISPLQRatyM-SSSNNNIEQHgSRPLcaAFDADSG-GD-VNDIPQLVALLLSL 112 Talaromyces ...
EEU42669        460 ----FGA-VWVSGFELSASYAVPDASILPMSTI---L-EMTRAMGEVQ-NLPL--IVDLDTGfGN-AVNVAYAVPRFAAA 526 [Nectria] ha...
EER17486         61 seakFDC-LWSSSLTSSTLKGMPDIETVDTTQR---L-QIVEDCLDVS-SLPM--IYDGDTG-GE-AEIFRFTVKKLERL 130 Perkinsus ma...
jgi:DaAHT2_1860 187 rrleFDG-MWLSSLTDSTAKGKPDIEAVDVTSR---M-RTLSDIVEVT-TKPI--LYDADTG-GR-PEQFAFTVRTLERF 256 Desulfurivib...
vbi:Arad_7864    49 gsqsFDG-MWASSLTDATARGMPDIEVVDVASR---L-GSLGEVMQVT-SKPV--IYDADTG-GK-AEHFAYTVRKLEWL 118 Agrobacteriu...
CBL17290         41 nqitFDG-LWLSGLCHAAAAGMPDDGRMPLSEK---L-TAVRTIRRVS-QKPL--LVDCDNG----QGDFSHTARAYAKA 108 Ruminococcus...
Q12Q29           43 ----FSG-IWASGLTISSSLGVRDRNEISWTQV---I-DAVEYMTDVV-DCPI--LLDVDTGyGD-YNSFRRVVKKLCQR 109 Shewanella d...
Q4DNR3           43 ----FKA-IWASGLSISAQMGFRDNNEASWTQV---C-DVAEQMSDAT-SIPI--LLDADTGyGN-FNNARLLVRKLEKN 109 Trypanosoma ...
Q98AR7           43 ----FKA-LWASGLSISSSLGYRDANEASWSQL---V-DVVERISDTV-DIPV--LVDGDSGfGN-FNNARLVARKLRQH 109 Mesorhizobiu...
WP_006773500     34 ----CKGaLLSASALTHTVHGTPDEGTLSTSEM---VwSLTRFVEDNC-SIPL--IVEVRSGfSDnLRIMPYDLERIVKA 103 Hungatella h...
EED17633        113 GVSMVIIEDKsvtapgkEVNslagashsqgqadMYEFAKVLRAFRAAAGDSEIMITARIESFTtrmvgkneakelasVRL 192 Talaromyces ...
EEU42669        527 GATAVVIEDKaf----pKDSslragg-rhalvsIPEFQGKIAAA----KVSPVLVIARTEALI--------------AGL 583 [Nectria] ha...
EER17486        131 GVGACVIEDKtg----lKQNslfgterkqqladVDEFCDKLAAGKDAQVTNDFMIFARVEALI--------------AGL 192 Perkinsus ma...
jgi:DaAHT2_1860 257 GVSGAVIEDKig----aKRNslfgagvgqvqasLEEMADKIQVGNRAKITSTFMIIARIESLI--------------LEQ 318 Desulfurivib...
vbi:Arad_7864   119 GVSAAIVEDKtg----vKRNslygtdvvqsqdtPDNFARKIAIAKKAQISQDFMLIARIESFI--------------LGK 180 Agrobacteriu...
CBL17290        109 GVSGLVVEDKcg----qKHNslygsarvqlledPRIFAQKLSDAKAHAPE--ILLFARLESLI--------------AGQ 168 Ruminococcus...
Q12Q29          110 NISGCCIEDKif----pKQNsfiger--qelasIAEFTGKIKAGIDHRENEDFVIIARTEALI--------------SGY 169 Shewanella d...
Q4DNR3          110 GVAGACVEDKlf----pKTNslldergaqpladVKEFALKIRAMKDTQTDENFCVVARVESFI--------------AGW 171 Trypanosoma ...
Q98AR7          110 GASGICIEDTaf----pKMNsfigdr--hpladIPEFCGRLKAVKDQVPDAEFVLVARIEALI--------------AGR 169 Mesorhizobiu...
WP_006773500    104 GAAAMLLDDRt-----fGCGsdspe---itlvsPEVFARKVAIAVEAASNTDCMVLARSYA------------------A 157 Hungatella h...
EED17633        193 AVDNALARAEVYKK-GGADAIMIRSKEKDPSeVLSFLAQFrSqd---vkTP-LVVVP----TtygsITDEELHQAG-ANV 262 Talaromyces ...
EEU42669        584 GEEKAIKRAMAYAE-AGADTVLVHSKQKTPDeILSFCKAWtGt------VP-LVIVP----TsypqLSFAEVAALDkVGL 651 [Nectria] ha...
EER17486        193 GQEEAMRRATAYLEkGGCDGIMIHSRHKDPQeIYEFLKVFrEqypdkvkTP-IILVP----TsynsVHESELAEHG-ANI 266 Perkinsus ma...
jgi:DaAHT2_1860 319 GQEDALRRAHAYID-AGADGIMIHSRQKTVDeIAAFCAEYrKfk---krVP-LVAVP----SsynsVYDHELQEMG-VDV 388 Desulfurivib...
vbi:Arad_7864   181 GLDDALMRAEAYLA-AGADGIMIHSREKLPDeVFSFCRKYnRfv---drKP-LIVVP----SsfnmTTEQALADEG-VNI 250 Agrobacteriu...
CBL17290        169 SMEDALERANIYAK-AGADGIVIHSLDKTGEqVLEFCHRCkQll---peMP-VACIP----TmypqLSCHTLHQAG-VNM 238 Ruminococcus...
Q12Q29          170 GIDEALRRAEAYYE-AGADAILIHSKSSNADeVLEFCNLFtAp------CP-IVIVP----TkyynTPTNVFEEAG-VST 236 Shewanella d...
Q4DNR3          172 PLEEALKRATAYAE-AGADAVLIHSKKKDSSeIDAFMAHWdNk------TP-VVIVP----TsyasVPCAHFREIG-IST 238 Trypanosoma ...
Q98AR7          170 GEDEALARAQAYAE-AGADAILIHSRKSNAEqIFAFTRAW-Qn-----rLP-VVIVPtkyyR----TPVSAYRAAG-IST 236 Mesorhizobiu...
WP_006773500    158 DQADAIARCKAAQA-AGAQMVGAVCMHTEDD-AREFAGAIaGsk----lWSdLTVKDgs-pE----VSAETLMELG-YGL 225 Hungatella h...
EED17633        263 IIYANHLMRAKITAGDAISsfFL 285 Talaromyces stipitatus ATCC 10500
EEU42669        652 IICGNHAVRAAVASMRRTFkhIL 674 [Nectria] haematococca mpVI 77-13-4
EER17486        267 IIHANQLIRAAYPAMKKVAteIL 289 Perkinsus marinus ATCC 50983
jgi:DaAHT2_1860 389 VIYANHLLRSAYPAMLDTArsIL 411 Desulfurivibrio alkaliphilus AHT 2
vbi:Arad_7864   251 CIYANQLIRSAYPSMVETArsIL 273 Agrobacterium radiobacter K84
CBL17290        239 VIYANHLTRSAYKAMCLTAgsIL 261 Ruminococcus champanellensis 18P13 = JCM 17042
Q12Q29          237 VIWANHSLRASVKAIRETAeiVF 259 Shewanella denitrificans OS217
Q4DNR3          239 VIWANHNLRACIAAMQASTrmIF 261 Trypanosoma cruzi
Q98AR7          237 VIWANHNMRAAISAMRQVCdrIL 259 Mesorhizobium loti
WP_006773500    226 VFITFMEKASWFGDIDFGTknwa 248 Hungatella hathewayi
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