Conserved Protein Domain Family
Asp_protease_2

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pfam13650: Asp_protease_2 
Aspartyl protease
This family consists of predicted aspartic proteases, typically from 180 to 230 amino acids in length, in MEROPS clan AA. This model describes the well-conserved 121-residue C-terminal region. The poorly conserved, variable length N-terminal region usually contains a predicted transmembrane helix.
Statistics
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PSSM-Id: 338873
View PSSM: pfam13650
Aligned: 153 rows
Threshold Bit Score: 39.5831
Threshold Setting Gi: 502502920
Created: 4-Apr-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7MAZ2         54 VPVTI-SG---K-KY---QFLLDTGAS-YTFIDNKLAKTLTQTTPEsKIPVTFhrMLSDGL-VTTSEKRLH-Kadltlwq 122  Photorhabdus ...
Q1INV0        186 VSVDF-AG---T-AV---RANVDTGAGrGIVLPRSLQSKLPLEAAPvP-TESL--HTVSGE-QAASRAQLKgA------- 246  Candidatus Ko...
Q8ZYZ8          6 VKAKF-RG---KgEVvydEILVDTGAT-FTVLPLEVADKLIETP----FTVEL--KLGNGE-KVVAKVYVA-E------- 65   Pyrobaculum a...
Q9XX53        499 VPIRA-NG---M-PQ---SALIDTGAH-ITLASRSVCKILGISQLKsSKRINT--VGLGGNaVKLAGVASV-T------- 559  Caenorhabditi...
Q54AS8        247 AALLI-ND---K-NV---RGLVDTGSS-LTIIWESIAKKLNLKVEGkSF--SV--NSASNN-EIKIVGSCD-Ti------ 305  Dictyostelium...
Q7KWM0        149 ATLNI-FG---K-PI---KGLVDSGSL-LSILWSSVAKQLSLQVIPkR--VKF--TTAYGQ-EIYSTGSAE-A------- 206  Dictyostelium...
WP_012791203  137 LKGIL-NNn--K-TV---NVQFDLGAG-TTCVNRQVAEKLGLQFDGk---TVV--TNTQGT-NETGTSSGN-T------- 194  Chitinophaga ...
WP_012361505  100 VKLKH-NQi-eI-QT---TMLVDSGAE-VSLISYKMGQDLGYQLADaESTLVA--ETIGGN-VEYV-LRNV-E------- 160  Cyanothece
ABL78845        6 APVKLyHGeksL-EV---KALVDTGAT-TLVLPRSVAEELGLRVLGk---MDV--ELADGT-VKKVDYSIV-E------- 66   Thermofilum p...
XP_002488568  579 ITANI-LG---S-DV---RIMIDSGAT-GNYMDPRTQEKLQILGRKkPTPIPL--TGLNGE-KLSEEGITD-Etgw---- 641  Talaromyces s...
Q7MAZ2        123 plaITLGNHTVPSSDPWIGIdmslfnqsI-GQ-ELD-GILGIDT 163  Photorhabdus luminescens subsp. laumondii
Q1INV0        247 ---MKLGGYSIQGPQLDFVD-----------E-FPM-GNLGYPI 274  Candidatus Koribacter versatilis Ellin345
Q8ZYZ8         66 ---AEIEG-RRGPVRIVAFK----------G---AI-PVIGVDT 91   Pyrobaculum aerophilum
Q9XX53        560 ---FRIGK-KLIEHLVHFTEgrc---tpEaDR-SYS-FIFGNDI 594  Caenorhabditis elegans
Q54AS8        306 ---IKLGKASA-KVNVNIVK--------D-NDtSID-CIFGVDT 335  Dictyostelium discoideum AX4
Q7KWM0        207 ---IVSLGTAINNCEFIIVQ--------D-KV-LNDsCIFGLSV 237  Dictyostelium discoideum
WP_012791203  195 ---LTIGNISWEAVRLTQVGn-------M-QE-GED-LIIGNSL 225  Chitinophaga pinensis
WP_012361505  161 ---FTIDNHQLIAPVAWLQT--------L-TD-TEQ-SLLGREV 190  Cyanothece
ABL78845       67 ---VELSG-RRAPVLVAIVE-------------RGE-VCVGVEA 92   Thermofilum pendens Hrk 5
XP_002488568  642 -laMSIDG-HLEMINFDIAK--------L-G--RDD-VILGIPW 671  Talaromyces stipitatus ATCC 10500
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