Conserved Protein Domain Family
DDE_5

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pfam13546: DDE_5 
DDE superfamily endonuclease
This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.
Statistics
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Aligned: 71 rows
Threshold Bit Score: 90.0765
Threshold Setting Gi: 163670557
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
csisp-ryc-ciber-uv:acin_1308  20 QFFTEFHvsqilrscnaYKLRGfavMAIFLVAFEAAFQR--RSFYQRKKDAp--eSIPFERDTFYRFLNsCAiHWRk-fT 94  Acidaminococcus intestini RyC-MR95...
Q82RB5                        38 EFYSCLT-----------ARSD---ALFELADAVLCGDGpvRSLAELSLVG----EHRRGHGGLYAALA-RG-RID---A 94  Streptomyces avermitilis...
AEV86658                      23 ELYQCMT-----------RRAD---ALFELTEALLCTEGpvKTLVGLSLAP----EHRRGHGALYDALN-HG-RID---V 79  Actinoplanes sp. SE50/110...
AEV86661                      19 EFYRCLT-----------ARSD---ALFELSDAVLCADGpvKTLVDLTLTA----EHRRGHGALYDALN-HG-RID---L 75  Actinoplanes sp. SE50/110...
CCK24563                      30 EFYECLT-----------ARRD---ELFELTDAVLCADGavKSPVDLTLLP----EHRRGHGAMYGGLN-HG-RLD---V 86  Streptomyces davaonensis JCM 4913...
EDY56157                      23 EFYECLT-----------ARRD---ELFELVDAVLCADGpvKSPVDLTLVP----EHRRGHGALYGALN-RG-RIN---V 79  Streptomyces sviceus ATCC 29083...
Q2JE07                        23 EFYDCLT-----------RRAD---ALFETAEAVLCTDGpvRTLVDLTLAP----EHRRGHGALYDGLN-SG-RLE---I 79  Frankia casuarinae...
jgi:Alvin_0642                19 RLYEHLG----------ARRDA---SLNLLDSLCANTQA--RSVVELSLNPaferDYTSLYAAIEAFTP-EPtARDpspS 82  Allochromatium vinosum DSM 180...
BAF99878                      19 QLYNALG-----------SRRE---TVMELLDSLSSNRQa-STVAELSLNPlfrrDYNSLYKGIQEFLP-SPtNDN---Y 79  Microcystis aeruginosa NIES-843...
jgi:Cyan7822_6160             19 NLYNGLN-----------ARKE---TLIELIDALSSNQQa-ASVVELSLNPlfrrDYNSLYKGIQEFLP-HQnEKS---Y 79  Cyanothece sp. PCC 7822...
csisp-ryc-ciber-uv:acin_1308  95 LLLGTAIIQKAIaPLTSGARRNv---LIIDDSLFSRnRSKKVELLARVYDHVSGTYM--KGFRMLTLGWSDGNTFLPLSH 169 Acidaminococcus intestini RyC-MR95...
Q82RB5                        95 GRLRRALAEVPL-PRAADGRLV----LAVDVTCWLRpDAHTSPQ--RILCHTYGRG---KDQHIPVPGWPYSIVCALEPG 164 Streptomyces avermitilis...
AEV86658                      80 EVLRRQLAGLPL-PRAADGRLV----LAVDVSPWLRpDGNCSPQ--RSFCHTYGRG---KDEHRMIPGWRYSIIAALETG 149 Actinoplanes sp. SE50/110...
AEV86661                      76 GRLRRALTAQPL-PRFADGRIV----LAVDVSPWLRsDAACSPE--RLFCHVYGRA---KSAAQFIPGWPYSFVAALEPG 145 Actinoplanes sp. SE50/110...
CCK24563                      87 DRLRAVLAGLPL-PRFDGGRLV----LAVDVSPWLRsDAPCSAD--RLFCHVYGRA---KTASQFIPGWPYSFVAVLEPG 156 Streptomyces davaonensis JCM 4913...
EDY56157                      80 DRLRALLADMSL-PRFDGGRLV----LAVDVSPWLRsDAACSAD--RLFCHVYGRA---KSASQFIPGWPYSFVAVLEPG 149 Streptomyces sviceus ATCC 29083...
Q2JE07                        80 ARLRRALADLPL-PAAADGRLV----LAVDVSPWLRsDASTSAE--RLFCHVHGRA---KNQSQLIPGWPYSFVAALESG 149 Frankia casuarinae...
jgi:Alvin_0642                83 TGLSALVSEQI--PAPSPARPFw--lLGVDTTPNPR-PFAATLADR----GVVYQPNpaPGNKPIAVGHHYSVVAALPER 153 Allochromatium vinosum DSM 180...
BAF99878                      80 QKAFDSLLSVVS-ATIPPPVSRqfylFGVDVTPCPR-PYSATLED-KKYIYQPNTI---KGNKPINIGHAYSVIAALPER 153 Microcystis aeruginosa NIES-843...
jgi:Cyan7822_6160             80 LEQINRLFDAAF-LTINQEKSRnynlLGIDTTPYPR-AYSATLAD-RTFIHSPNPI---KGNKPISIGHTYSVVCALPDR 153 Cyanothece sp. PCC 7822...
csisp-ryc-ciber-uv:acin_1308 170 CLLSSSSKQQQlQgasedvDPRSNGGKQRKL-AQCKAPEVVLTLLQEA-RETGAPAQHVLFDSWFCSPASL-HQIHELGY 246 Acidaminococcus intestini RyC-MR95...
Q82RB5                       165 R----SSWTAPlD------ALRLTPGDDTATvTARQLRDLLQRLITAGqWQTGDPDILIVADAGY-DAPRLgFLLRDLPV 233 Streptomyces avermitilis...
AEV86658                     150 R----TSWTALlD------AVRLLPGADVTTvTCAQIRQFVDRLTDAGqWQAGDPDILIVLDAGY-EAPRIaWLLRDLPV 218 Actinoplanes sp. SE50/110...
AEV86661                     146 R----TSWTAMlD------VVRLGPADDATAvTATQLRGVVDRLIACGqQQAGDPHILIVCDAGY-DVTRLaWVLRDLPV 214 Actinoplanes sp. SE50/110...
CCK24563                     157 A----TSWTALlD------AVRLGPVDDATAvTATQLRGVVERLITCGqWQPGDPDIVIVSDAGY-DVTRLaWVLRDLPV 225 Streptomyces davaonensis JCM 4913...
EDY56157                     150 A----TSWTGIlD------VVRLGPEDDATAvTAVQLRAVVERLIAAGqWTPGDPDITIVMDAGY-DVTRLaWVLRALPV 218 Streptomyces sviceus ATCC 29083...
Q2JE07                       150 R----TSWTALlD------AVRLGPTDDATAvTADQLRAVVGRLIAAGhWHDGDPNILIVMDAGY-DVTRLaFVLADLPV 218 Frankia casuarinae...
jgi:Alvin_0642               154 SRCHP-PWVVPlQ------ARRVASNTTA---TAVAASQMAAVLADPA-QPYATALSVQVADSHYSHAAYL-HALSAFSN 221 Allochromatium vinosum DSM 180...
BAF99878                     154 SETGNVPWAIPlS------GQRVSSGEKDISvASNQVK----KILNHSsVPWKDKLSVLVADSLYSQRGFLgEQVKQNNL 223 Microcystis aeruginosa NIES-843...
jgi:Cyan7822_6160            154 NLTGNVPWVVPlS------GERLQSQEKATHvANQQLKKIIKNSLFPA-----KQLSVLVVDSLYSQRDFIgEQVQHENL 222 Cyanothece sp. PCC 7822...
csisp-ryc-ciber-uv:acin_1308 247 DVIARVKKSEKMHFCFQGRMQDVMAIYRsQKKRr------GRSAYLLSVEA-------------------EAVKDGERLP 301 Acidaminococcus intestini RyC-MR95...
Q82RB5                       234 QVLARMRSDRVLRR-----AVPPRLPHTqGRPPrhggefvFGQPDTWDTPDtetvtdtr----lygqataRSW-NRLHPK 303 Streptomyces avermitilis...
AEV86658                     219 EILGRMRSDRVLRRA----TPARVYKPLgGRPTrhggefvFGNPATWDIEHavthtdtr----lygqvraQAW-DRLHPR 289 Actinoplanes sp. SE50/110...
AEV86661                     215 EVAGRIRADRVLRLP----APPYEHSPSgGRPPkhggefdLKDSATWPEPAattineti----sygkaeaRAW-DRLHPR 285 Actinoplanes sp. SE50/110...
CCK24563                     226 ELVGRVRSDRVMRLP-----KPLRQPGTnGRPPkhgpefrFAKPETWPEPAvttvtdta----nygkaetQAW-DRVHPR 295 Streptomyces davaonensis JCM 4913...
EDY56157                     219 ELVGRIRSDRVMRCPAPSREEFHRAHPRaGHPPkhgpefrFAKPETWPEAAittatgtv----nygktetQAW-DRVHPR 293 Streptomyces sviceus ATCC 29083...
Q2JE07                       219 EVLGRIRSDRVLRL-----AKPPRQPGTnGRPPkhgpefaLDRPATWPELQhttttnts----rygtataTSW-NRLHPR 288 Frankia casuarinae...
jgi:Alvin_0642               222 HVVIARSAGNRVYS-----RAPPATDGAcGHPIwygeafrLADPETWGSPCq-----------------sAEWPDQTASG 279 Allochromatium vinosum DSM 180...
BAF99878                     224 VTLTRGRSNRVFYRQF---IPEDYSPKQpGHPRwygdkfdLKDETTWLEPDeiiqstfttkrgrelnlkiSGWKQMLMRG 300 Microcystis aeruginosa NIES-843...
jgi:Cyan7822_6160            223 IPITRVRSNRVFYRQF---ISQKGDSPSsGHPRwygdkfdLKDETTWTNPDevsqcffttkknrhltvtiSAWQQMLmrg 299 Cyanothece sp. PCC 7822...
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