Conserved Protein Domain Family
UvrD_C

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pfam13361: UvrD_C 
UvrD-like helicase C-terminal domain
This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Statistics
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Aligned: 24 rows
Threshold Bit Score: 119.515
Threshold Setting Gi: 8134451
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
PRJNA437124:C6362_11115     273 ITFTTNYRATQLLLKAAEGCLNRLFGQvTVHHiypqpgqaAAAVPGD-----PIVVHKADNFIGESRWIFQELMRLP--- 344  Megasphaera elsdenii DSM 20460...
P44804                      271 IKLEQNYRSTQRILHCANILIDNNEHVfdk-------klfSTIGKGE-----KLLVIEAKNEEHEAERIVAELIAHRfs- 337  Haemophilus influenzae Rd KW20...
Q02322                      281 IRLEQNYRSTANILNSANELIANNSDRlgk-------nlwTEGEKGD-----PVGIYSAFNELDEAKFVASQIQDWVe-- 346  Haemophilus influenzae Rd KW20...
O51319                      272 FYLVQNYRSNSNIVGIANEVISKNKNRyek-------qitTQNSSNK-----RMKFLVFQSTSDEAEYFSNLLISND--- 336  Lyme disease spirochete...
O66983                      251 IKLELNYRSREPILRVANAVLEASTLEwkdli----pklrGVRGEGQ-----KPYVRRFQDEEEEALWISRKIKELAg-- 319  Aquifex aeolicus...
Q10213                      295 LHLERNYRSAKPILELALSIISQDKSRpkk-------glkSNHISSL-----KPHYRLFETNNKESYWIAREIKRIVgsc 362  Schizosaccharomyces pombe 972h-...
O26611                      282 VMLEKNFRSVPSIVDVTQRFMdgyre---------ypkdiRPVRDSEn----RVFILDNPTHQDEPSNVVGIIRALVdh- 347  Methanothermobacter thermautotrophicus str. Delta H...
WGS:ACWZ:HMPREF0669_00649.1 327 YHLHTNHRAPSYLVKVLNTFAQHQLHIaPELLpst---lkETQQIGD-----ELKIITSGTLEEELRDTALLAQKLLn-- 396  Prevotella sp. oral taxon 299 str. F0039...
WP_094466392                334 YHLNINHRSPASLLAMTNHYAAEVLGVdRALLp--------TAQPSDaadcaEMRLIESPLIDSEYHDVAAL-ARKLa-- 402  Prevotella sp. P5-108...
WP_014708362                328 HHLLQNHRSPKYLLDVFNDYAEHQLHIdRELLplt--dndAKAQQGD------LVVLTSNTVEEETDAVAATSARLLq-- 397  Prevotella intermedia...
PRJNA437124:C6362_11115     345 --QQERLKACVLVRG-NRQAQQLWTGINAHNqhyppedqLPVTCIDQFHLFKRQECKDVLAYLRLLLNKHDNLSLKR--- 418  Megasphaera elsdenii DSM 20460...
P44804                      338 -rKTKYKDYAILYRG-NHQSRLLEKVLMQNR--------IPYKISGGTSFFSRAEIKDMMAYLRLVVNQDDDAAFLR--- 404  Haemophilus influenzae Rd KW20...
Q02322                      347 -hGGKLDDCAVLYRS-NSQSRVIEEALIRCQ--------IPYRIYGGMRFFERQEIKDALAYLRLINNRQDDAAFER--- 413  Haemophilus influenzae Rd KW20...
O51319                      337 ------IKTAILYRF-NSQSFHFETSFLKKN--------IPYKVLGSIKFYDREEIKDIICLLRLFINKKDKISFLR--- 398  Lyme disease spirochete...
O66983                      320 --EYELKDIAVLVRV-GYITDVFERTFFKAG--------IPYKVVGTIKFYERIEIKNLIALLRLIYNPSDEVAFKR--- 385  Aquifex aeolicus...
Q10213                      363 peLIFYNDIAILVRS-SSLTRSLEHALSELG--------VPYRMVGVNKFFDREEIRDLIAYLRVLANK-DSTSLIR--- 429  Schizosaccharomyces pombe 972h-...
O26611                      348 gvIPHQGYVTLLFRSvKHDAVEIMNELRREG--------IPFNVYGEGGFFDREEILYIMHLLHHTRNERRKIIRKLkye 419  Methanothermobacter thermautotrophicus str. Delta H...
WGS:ACWZ:HMPREF0669_00649.1 397 --DHPNETTSIIVSS-NADADKISEELKTQH--------IPHFKVSGQDLFSTPLVKLLIAHLGVIANEHNFIAWSR--- 462  Prevotella sp. oral taxon 299 str. F0039...
WP_094466392                403 -lADNRETTAIVVNS-NYDADKVGEALHALD--------MPFFQVSGTDIFASVQVKTMLAHLNVLASETNFMAWAR--- 469  Prevotella sp. P5-108...
WP_014708362                398 --QDKEATTAVIVNA-NADADKVSRALERHG--------VNHLKVSGRDLFDTPAMKTLIAHIAVLNNEQNILAWSL--- 463  Prevotella intermedia...
PRJNA437124:C6362_11115     419 ILLRFVPRIGRRTVETIeSESYRRLGLRLCDFIDPISQETGDPYGlllSALDEGR-IVV--FDVESTGTD---------- 485  Megasphaera elsdenii DSM 20460...
P44804                      405 IVNTPKREIGTATLQKL-------------------------------GELAQEK-HIS--------------------- 431  Haemophilus influenzae Rd KW20...
Q02322                      414 VINTPTRGIGDRTLDIL-------------------------------RNLTRER-QIT--------------------- 440  Haemophilus influenzae Rd KW20...
O51319                      399 MINKPSRGIGKTTLDKI-------------------------------ISSLNDK-DVN--------------------- 425  Lyme disease spirochete...
O66983                      386 LTEFFVKGFGDKSFEVV------------------------------------KK-NFK--------------------- 407  Aquifex aeolicus...
Q10213                      430 VINVPPRNIGKTKIDRI-------------------------------IFESERR-GLT----------F---------- 457  Schizosaccharomyces pombe 972h-...
O26611                      420 HLEGEFMDLTPGSVNRI-----------------------------------------LdmDEEELRGLRehrefrgagf 458  Methanothermobacter thermautotrophicus str. Delta H...
WGS:ACWZ:HMPREF0669_00649.1 463 ILKGLKIFSTNAASQRF-VRLLNERAISVSDLLNDAPSTYVERFV---RHYEQDT-LVV--FDTETTGLN---------- 525  Prevotella sp. oral taxon 299 str. F0039...
WP_094466392                470 LLYGLGVFAAPASAREF-MRKMLNRALLPSDFLLYDSTTYVQDFV---AAVDADApVVV--FDTETTGLS---------- 533  Prevotella sp. P5-108...
WP_014708362                464 LLKGLKVFDSKGLARRF-VHKLRQLSLSPTDFLLYKDSNYTADFL---QNYNDGD-IVV--FDTETTGLN---------- 526  Prevotella intermedia...
PRJNA437124:C6362_11115     486 TTRDEIIQIAAVRLDAQGQV-A--DTFNTYVRASRPVGASFYVHHISDETLEAQ------GMEPRQALTAFLDFAKDAVI 556  Megasphaera elsdenii DSM 20460...
P44804                      432 LFEAIFEFELIQRITPKAY-----DSLQKFGRWIVELNDEIQ------------------RSEPERAVRSMLSAIH---- 484  Haemophilus influenzae Rd KW20...
Q02322                      441 LWQAVQVATQENMLAGRAS-----TALLRFQELINSLQLDTA------------------EMPLFAQTDFVIKHSG---- 493  Haemophilus influenzae Rd KW20...
O51319                      426 FNLFCASKKTLGLLKNRAK-----ESLLLFLNVYEELGKKLFEDN---------------YINLSAFIEDVVIRFGLLD- 484  Lyme disease spirochete...
O66983                      408 GNWFKALKESLKKLPKNAAI-SayEFLKAVVPLYKN------------------------PEKYHEGLEAFVEKID---- 458  Aquifex aeolicus...
Q10213                      458 WQTLNEVKNENILLSQRNDK-SflKSLKSFLCSISKLENRYLSNGH--------------SATLSDLLLGILSEIK---- 518  Schizosaccharomyces pombe 972h-...
O26611                      459 TDPDDIRKLVALNRLIDSDL-GvlERYYEILELTE--------------------------------------------- 492  Methanothermobacter thermautotrophicus str. Delta H...
WGS:ACWZ:HMPREF0669_00649.1 526 VLEDDIVQIAAVKIAKGKVL-En-ERFEIFIDTKRPIPAMLGDIENPLIEEIKKh----tLHTPAEALARFMEYIDGAML 599  Prevotella sp. oral taxon 299 str. F0039...
WP_094466392                534 VFDDDILQIAAVKMQHGRMVqG--SSFVVHIQTERPIPEMLGDIPNPIIEERRHa----tLVSHAEALRQFVDYIGDCRL 607  Prevotella sp. P5-108...
WP_014708362                527 VFADDIIEIAAIRLHKGEIV-G--EPLDLYIRTDKPILPKLGEKDNPMYAIYHEkmhsgqLLSPAEALQRFWQYVGDAAI 603  Prevotella intermedia...
PRJNA437124:C6362_11115     557 VGHNVTYDLSILHSELQRL--GMGESGD-FPYYDTLDIYRRFYPNLINHKLATLSET--FPIDHQPSHDAFDDILATAGL 631  Megasphaera elsdenii DSM 20460...
P44804                      485 ------YEEYLYEYATSpka------------------------------------------------------------ 498  Haemophilus influenzae Rd KW20...
Q02322                      494 ------LYEMYQQEKgek-------------------------------------------------------------- 505  Haemophilus influenzae Rd KW20...
O51319                      485 ------YYRKFDKDE----------------------------------------------------------------- 493  Lyme disease spirochete...
O66983                      459 ------YYELLKEKFkkd-------------------------------------------------------------- 470  Aquifex aeolicus...
Q10213                      519 ------YYEYLVRKNket-------------------------------------------------------------- 530  Schizosaccharomyces pombe 972h-...
O26611                      493 ------YPHRLLERGDDESr-E---------------------------------------------------------- 507  Methanothermobacter thermautotrophicus str. Delta H...
WGS:ACWZ:HMPREF0669_00649.1 600 VGHNATYDYQILYNNLLRYlpQYTFLQKhSSYIDTLKLTRLLQPSLKNYKLKNLLQE--FQLEGQNTHLADADVHATVGL 677  Prevotella sp. oral taxon 299 str. F0039...
WP_094466392                608 VGHNVEYDYQILVHNLSRYlpDVALPAH-DRCIDTLKLLRLLHPELVSYRLDFFRRQhlFGLSEDNAHLADVDVEDTCRV 686  Prevotella sp. P5-108...
WP_014708362                604 LGHNVAYDSNILDYNMRRYtpADSMKNHtNPCFDSLKLIRLLAPGLPSYKLETLLEH--FQLAGINSHQAIDDVAATISL 681  Prevotella intermedia...
PRJNA437124:C6362_11115     632 LCYAVTKqIRPATTAR------------R-------------SSLAIYLPLFAPFSRDIARFRRQSYQDRpidliaavmn 686  Megasphaera elsdenii DSM 20460...
P44804                          -------------------------------------------------------------------------------- Haemophilus influenzae Rd KW20...
Q02322                          -------------------------------------------------------------------------------- Haemophilus influenzae Rd KW20...
O51319                          -------------------------------------------------------------------------------- Lyme disease spirochete...
O66983                          -------------------------------------------------------------------------------- Aquifex aeolicus...
Q10213                          -------------------------------------------------------------------------------- Schizosaccharomyces pombe 972h-...
O26611                          -------------------------------------------------------------------------------- Methanothermobacter thermautotrophicus str. Delta H...
WGS:ACWZ:HMPREF0669_00649.1 678 VHFCYQQsVEKLKGQSeflahpkvdakvQ-------------KLKRLYGDIYRQAQQELWKKQDTTQSSA---------- 734  Prevotella sp. oral taxon 299 str. F0039...
WP_094466392                687 MAHLYRR-CREVIPEQ------------QefldraatrraadMLRRNYRDLYVRAREQLYDHAPAGDSPA---------- 743  Prevotella sp. P5-108...
WP_014708362                682 VRLCADKaTQQQPLQAafmahkqvvpyvQ-------------RFRAAYAPLFNTALLHCYELKAGNQKALveevknty-- 746  Prevotella intermedia...
PRJNA437124:C6362_11115     687 eggvkawyeshrdpsdaaqhidRLENVRKLYRIAKETDD--PGQDp----------------------RDA--------- 733  Megasphaera elsdenii DSM 20460...
P44804                      499 -------------------aemQSKNVATLFDWVADMLKgdETNEp----------------------MN---------- 527  Haemophilus influenzae Rd KW20...
Q02322                      506 -------------------gevRIENLEELVTATREFIKpdNAEEm----------------------TE---------- 534  Haemophilus influenzae Rd KW20...
O51319                      494 ----------------------KLRNIDELINSGIEYSGtfEG------------------------------------- 514  Lyme disease spirochete...
O66983                      471 -------------------yeeRIENVKEFLSSLKDFYAkaYT------------------------------------- 494  Aquifex aeolicus...
Q10213                      531 -------------------veeKWENVMELVQQSDNISCifYELDy----------------------KISti------- 562  Schizosaccharomyces pombe 972h-...
O26611                      508 ----------------------KLYNLARFSSLIKDYERisLEPGv----------------------EG---------- 533  Methanothermobacter thermautotrophicus str. Delta H...
WGS:ACWZ:HMPREF0669_00649.1 735 ----------------------LISQLVWFYNQVVEAEI--MKPLs----------------------ATEyvfnyiene 768  Prevotella sp. oral taxon 299 str. F0039...
WP_094466392                744 ----------------------MVGQMRAVYDYLRQMGGdhAQPHkidyvlsyiahdivdsslapslaEQL--------- 792  Prevotella sp. P5-108...
WP_014708362                747 ---------------neliaqgLIGEIDRLPYFLRYLEL-------------------------------Dlltdesip- 779  Prevotella intermedia...
PRJNA437124:C6362_11115     734 --------------LAEFLKLT---------ALSNSELDSMLAKd-PKIPIITIHQAKGLEFDYVFLAHLEDRVFPTFWS 789  Megasphaera elsdenii DSM 20460...
P44804                      528 --------------LNQVVTRL---------TLRDMLERGEDDDdsDQVQLMTLHASKGLEFPYVYLIGMEEGILPHQT- 583  Haemophilus influenzae Rd KW20...
Q02322                      535 --------------LTAFLTHA---------SLEAGEEQASPHQ--SCVEMMTLHSAKGLEFPRVFMVGVEEGLFPSFRS 589  Haemophilus influenzae Rd KW20...
O51319                      515 --------------LAIFLENS---------SLSPLISGDFK----SNILLSSIHGVKGLEFDRVVISGLEKGLLPAEIE 567  Lyme disease spirochete...
O66983                      495 --------------LEDLLAEI---------TLTSEEEEEE-----NAVKILTIHSAKGLEFPVVFLPRLEEGILPHHRS 546  Aquifex aeolicus...
Q10213                      563 ------------vlLQNFLTQI---------ALVNEEQKEGES---QKVTISTLHAAKGLEWPVVFLPCLCENIIPHSR- 617  Schizosaccharomyces pombe 972h-...
O26611                      534 --------------LMEFIRMAmsgrikkydQILLDNP--------YSVNIMTMHRAKGLEFPVVIICSVFNGKFP---- 587  Methanothermobacter thermautotrophicus str. Delta H...
WGS:ACWZ:HMPREF0669_00649.1 769 mvdkhaenclaqqlFLHVNEIA---------TLKEADLCGSSIIh-EKIFISTIHKAKGLEFDNVIVYDVAEGRYPNYFI 838  Prevotella sp. oral taxon 299 str. F0039...
WP_094466392                793 --------------QRHLMETN---------TLKESDLCGSDVLd-ERIFVSTIHKAKGLEFDNVIVFDVVDGRYPNYFT 848  Prevotella sp. P5-108...
WP_014708362                780 -------nalieqiNRYMLEIS---------TMKESDFCNSKSLn-ERVYVTTVHKAKGLEFDNVIVFDAAAERYPNKRN 842  Prevotella intermedia...
PRJNA437124:C6362_11115     790 V-K-----------------------KGNIEEEKRLFYVAITRAKKRLYLIWHEG 820  Megasphaera elsdenii DSM...
P44804                      584 S-Id----------------------EDNVEEERRLAYVGITRAQKELTFSLCRE 615  Haemophilus influenzae R...
Q02322                      590 F-Ee----------------------PGRLEEERRLAYVGITRAKKKLTISYAES 621  Haemophilus influenzae R...
O51319                      568 E-Lt----------------------EDRLEEERRLFYVAITRAKSELIVTLNLR 599  Lyme disease spirochete
O66983                      547 Q-Es----------------------ERELEEERRLFYVAITRAKDLLFMSYTKK 578  Aquifex aeolicus
Q10213                      618 --------------------------SDDLDEERRLLYVGATRAQALLYLSSFKS 646  Schizosaccharomyces pomb...
O26611                      588 --RkvrerselelpeelrrstmrtdeI----EERRLFYVGMTRAQDMLIVSATKN 636  Methanothermobacter ther...
WGS:ACWZ:HMPREF0669_00649.1 839 K-Dnpe------------------lvL----EDARKFYVALSRARKRLWMIYAST 870  Prevotella sp. oral taxo...
WP_094466392                849 RdD-----------------------EAQCAEDRRKLYVALTRARRRVYVAWSSG 880  Prevotella sp. P5-108
WP_014708362                843 T-T-----------------------EKQNQEDARKFYVAMSRAKRRLIVAYSLT 873  Prevotella intermedia
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