Conserved Protein Domain Family
AAA_21

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pfam13304: AAA_21 
AAA domain, putative AbiEii toxin, Type IV TA system
Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.
Statistics
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PSSM-Id: 315880
View PSSM: pfam13304
Aligned: 79 rows
Threshold Bit Score: 35.1052
Threshold Setting Gi: 0
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81614260    27 IIGIIGQNSSGKTIILETIELVfqimnmekflnsnlFSYQSFLNYLQkdnlGLNLISSYSPFYIHKKIEKFLNIlFFDKN 106
35_pfamImport   1 LSVVAGANGVGKTSFARAL-----------------AGDSRYSVIAG----FEWARWRRGPGAVLGVFLTFQAP-VEVPG 58
24_pfamImport   1 FNLVLGPNGSGKTSLIEALQHL-----------------------------------RTLSQLEPMDPITAHVT-EDGPS 44
gi 81834368    24 RVFVVGPNASGKSNFLDVFRFLrd-----------iAKPGGGLQKAVvargGVSKIRCLSARREPNIEIEIHISeSVNRS 92
48_pfamImport   1 VSVLIGANNAGKSSVLQALDFLq-------------DCVLHGVTSAAqmngRHGFFDLRTRGTDEPMSLRILFS-SAKTG 66
gi 81663612    23 VTVLVGRSGTGKSNFVEAVRFLrdll------rgqpGGSGGGMGGVFgggqNPFALMRPLPMTEAPTRFEICFS-VRSSK 95
46_pfamImport   1 VNVLIGPNGAGKTNVLKVFRFLadm--------irtDLIPAMDEHGGfdeiLFRGGESIPDHFRIKLKAAWTPHaTLEDS 72
gi 81835193    23 LTVVTGPNGSGKTNLYRSLRLIas----------aaNGNLNQSLAEEggfeSVLWAGPESIPNEMKRGDVPVQGtLRRKP 92
gi 81826726    41 LNVVVGGNGAGKSNLISFFKM---------------LRALIDGNLNRyvieHGGAGDLLFNGRKTTEKMEFETH-FNSRG 104
gi 81852882    25 LIVMIGANGAGKTSFLDVL-----------------STLAASANGKLqetlQSKGGLNEILTRGKAQELEIEVSmRVPQE 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81614260   107 KKFVFNIFFQNGDNy------KMIISNQNENVSIFLYFNEILKEEILNFNNFIRNFYLYYFSFETKILNSKEEIEKIFFE 180
35_pfamImport  59 VLYAHFLKLVACRA------------------------------------------------------------------ 72
24_pfamImport  45 MVFQFTAPFERLQV---------RLACVDSNRCDAIHLTPPDAPDWPALKAEIERIRSFAFDPEAMASPTPLQPGAELAA 115
gi 81834368    93 ALWRYEIGVKQETR----------GNRQPKLAYERVYKEDKLILDRPDEFDKNDDVRLTQTHLEQIVANLSFRDIAKFFE 162
48_pfamImport  67 IIYNYMLQIGDNDQ----------GKPLITAESLQIVEQEKGDFFRCADDKFTARFGTHEESQVVKPYDLPLLSVYAKLP 136
gi 81663612    96 ERYRYLLDLGKSPE-------QGRFGEEKLLLGDTILYHQSSDKNAMAWIQEPRLVDIPKPGGIALGRMPSLSDVVVAYA 168
46_pfamImport  73 DEYELVVALNDPASqgqltrfERFKFPGPQGGNEILIRSDAVEVRAVSVRHTPSILDVLRSDAHMRTTGISSLSSGLSTL 152
gi 81835193    93 IALKLAFSADPMSYci---dlGRPVPSNSMFDGDPEIKRECIWTGPTPDARSLCVDRKGANLRCRSGKGKWQDIDLHLSR 169
gi 81826726   105 YRFKLIPTPKDACS-------LEEEARYYESGLTGWWELGDSHDGTSRMVSEVTENRSDGQYSKPIYDAISSWQIYHFHD 177
gi 81852882    88 QPLKYGLTLSPKGLsye--irNETLTQQRNPNKSEPFKYIESHGLDIKYFQEGSGLLRPNWEHNPLETSLSQVPKMYREP 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81614260   181 QNKKISNFKKEYEILNLEItylaesrpiDISNFNNRINYIFYFFKSQKIEDQYKKYKEKFLKWMKISDAWIDdfei---- 256
35_pfamImport  73 ----------------------------GTAPSLACKLKLVLKLVGVSVRALNRPVNVGF-------------------- 104
24_pfamImport 116 DGANLAAVLADWRETARAA---------YDAFVAEALRLFPEYTKFELQSRPGHHVALAFTLLGEVGVVSGEd------- 179
gi 81834368   163 SVLYLHLVPQLLRHPEAFSgpa----ipEDPFGRSFLERVAKTPEKTRRARLLKIEEALKFAVPQLKKLSDVrdelg--- 235
48_pfamImport 137 GADFCREPYEYIEHWLYISfp-----alMNQPGRASRDFMLQASQLGNLSGGHRHINRYADNVPNVLAYLQKkhpniyq- 210
gi 81663612   169 ALTEGIGCYTFPNSVMLIGapa---eagQSGFQDSGANYLDTMKKIVSNFQDASARQRIVKSLQRVNEGVSSvelndl-- 243
46_pfamImport 153 PRLSEEAGAREVRALASRLg--------EFRVFDVSVDAARRPSRLLQRGGDSLEDDAANLAAFLLTLRKEDsdawsrle 224
gi 81835193   170 GTSLMTEYADPFAAPEIIVmke---qlrGWRFYDTFRCDSHAPARLPSPQTFTPVMANDGSNLAAALQTIREigdshive 246
gi 81826726   178 TGSRAGMRHYEIIQDNKSLr--------ADASNIGPFLLKLKKKHPQEYKDILNAIRLVTPFFEDFLLEPREsgnk---- 245
gi 81852882   166 ENLRKSLASCTYYGALDVSek-----spIRLPQPMRPAKLPGASGEDLVSCLYDLRETDGDRFEMVEDVVSTafpdferl 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81614260   257 ----------------------qndFYWYFKNTKGELINWNQLSKGTQKWaAFFYDIISRYLLKdkitvnknIFFLIDEI 314
35_pfamImport 105 -------------------------------------------SGGERRL-LELVQMVVMEP----------DVCVLDEV 130
24_pfamImport 180 ------------------------------------------lSQGTLHT--LAVLALASMPQPp-------SVVCLEEL 208
gi 81834368   236 --------------------vphleAVYEHWRPNAGKQREDQFSDGTLRL-IGLFWALLETD----------SLLLLEEP 284
48_pfamImport 211 ------------------eflqtvrQSVKLTANLKNALINSDFSNADARY--FLLVLLLFDPKPr-------SLLLLDAP 263
gi 81663612   244 -------------------rqpqyaIVGHLFNDKTLELKLSQESEGFRRF-YAHLLALYQQPPK--------LAMLFEHP 295
46_pfamImport 225 edavtvlpqlesidfeypsgaarevVVVLHERGLRRPTQLADASYGTIRL-LGLLALLYDPRPP--------ALTCVEEI 295
gi 81835193   247 qaieeaf----pgsqlyvqsgengmQVVLTQPGMLRGLTARELSDGTLRY-LLLLAALFSPRPP--------ELLVLNEP 313
gi 81826726   246 ----------------------eevNISWRQNGSDYPMQPYHLSDGSIRF-ICLATALLQPMPP--------AAIIIDEP 294
gi 81852882   241 n---------------fppvaagtiSMTWTDRNFSQPIYVHELSEGTLRF--LWLVTLLQSQSLt-------TITLLDEP 296
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 81614260   315 ENFMHL----KLTKTFI-----DLMiqyfenNLNnsigkIHL-IYTTHQ-PLLFE 358
35_pfamImport 131 DSGLDA----HKLAILI-----KLVl-----AFGa---sRRClLVITHS-LDLML 167
24_pfamImport 209 DHGVHPrtlrELRDALYrlaypESV------GLKrp--aVQV-VATTHS-PYLLD 253
gi 81834368   285 ELSLNS----GIVSRLP-----SIM------YRLqrqkrRQV-VISTHSyELLSD 323
48_pfamImport 264 ESELYP----DKINSLA-----EQL------RRFsfktsSQI-LLTTHS-LGLVD 301
gi 81663612   296 EDAVHP----GAFSLLAe----EFL------AAPme-grGQV-ILTTHS-PGLLD 333
46_pfamImport 296 DHGLHP----QALELLV-----ERL------REAse--rTQF-LIATHS-PAFAD 331
gi 81835193   314 ETSLHP----ELIEPLA-----NMI------CRAae--rSQV-IVVSHN-QQLVA 349
gi 81826726   295 ELGLHP----AAIVILA-----ELI------QIAsq--kTQV-IIATQS-PALMD 330
gi 81852882   297 EVSLHP----ELLRHLV-----YWM------REAsk--yTQL-IVATHS-DRLIR 332
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