Conserved Protein Domain Family
CENP-Q

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pfam13094: CENP-Q 
CENP-Q, a CENPA-CAD centromere complex subunit
CENP-Q is one of the components that assembles onto the CENPA-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENPA nucleosomes directly recruit a proximal CENPA-nucleosome-associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENPA NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENPA-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta7 is the equivalent component of the fission yeast Sim4 complex.
Statistics
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Aligned: 83 rows
Threshold Bit Score: 43.8823
Threshold Setting Gi: 1174681923
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:THITE_2093247 498 RLRGKLVKgMPFPPatttttsssspssappskprttrassssskrqqqqheprdggrEAELDFEKTVDAIAALERVLDPL 577 Thielavia ...
Q4SHZ5            104 gFLADCAK-LKVPH-------------------------------------------RRQKHVEGLFQHHQEETKRLNVA 139 spotted gr...
3_pfamImport        1 RLPQLCET-LKVPP-------------------------------------------EKLKDLTRVSSLLNVE-LQERTN 35 
XP_003467922      112 RLLQLCET-LKAPR-------------------------------------------QKLTYLTNMSSLLKIERAQDRAN 147 Domestic g...
EHB10238           30 RLLQLCEI-MEAPP-------------------------------------------RNLKYLTNVTRLLKAERAQDRDN 65  naked mole...
XP_003311370      116 RFLQVCET-LKVPP-------------------------------------------KKMEDLTNVSSLLNMERARDKAN 151 chimpanzee
XP_005318648      116 RLLQLCET-MKVPP-------------------------------------------RKLKYLTNVSNLLKMEKAQETAN 151 thirteen-l...
XP_008261250      114 RLLQLYET-LKAPS-------------------------------------------KKLKDLTNVSSLLNMERAQERVN 149 rabbit
EFB15241           64 RLLQLCET-LKVPP-------------------------------------------KKLKDLTNVSSLLKMEKAQHRDN 99  giant panda
XP_020568795      122 KFLSECAQ-LKVPK-------------------------------------------TKQKHTVHLSLRHQEESKKSLMG 157 Japanese m...
jgi:THITE_2093247 578 LHSAALLRAERD-REQRALKRDYALLRRLEANARAQARS-WRE--GRGREHVLAAavgagagpgagagpgagagevvvva 653 Thielavia ...
Q4SHZ5            140 KTTLSALEGDLR-AVAIALEKAEEQATSLQQECSLLRDQvEEEeeKAKQ---MLQraehgalr----------------- 198 spotted gr...
3_pfamImport       36 KERLALLLKEIE-KVVETAELMTENIQSLKNKIEILAREvEEEekTLKQ---VLQmdsrsvfs----------------- 94 
XP_003467922      148 EEGMALLQEEID-KIVQTTESVTGNIKSLKNKIEILTHE-IEE--EEEKAKEVLQldrhnvls----------------- 206 Domestic g...
EHB10238           66 -EGLALLQEEIDnKIVQTTESVTGNIQSLKNKTDILTHEiEEEeeKAKE---TLQldrrntls----------------- 124 naked mole...
XP_003311370      152 EEGLALLQEEID-KMVETTELMTGNIQSLKNKIKILASE-VEE--EEERVKQMHQinssgvls----------------- 210 chimpanzee
XP_005318648      152 EEGLALLQEEID-KMVETTESMTENIHRLKNKIQIVAHE-VEE--EEEKVKQMLQmdssgvls----------------- 210 thirteen-l...
XP_008261250      150 EDGLTLLQEEID-KLVETTELMTGKIQSLKNKIRILASEvEEEeqK------MLQmsssgvls----------------- 205 rabbit
EFB15241          100 EEGLALLQEEID-KIVETLESMTGNIQSLRNKVQVLTSEvEAEeeKVKQ---MFQidssgvlc----------------- 158 giant panda
XP_020568795      158 QKTLSLLKEDLK-SVVNALQKVEERTVSLEHACSSLREElEEEeeKAKE---ILQiadrsvlk----------------- 216 Japanese m...
jgi:THITE_2093247 654 ksgsgsgggngavfQDLQD--EEELLALSQ-----QIGSHMESMRSNLAQIEGVLPAIAKSRAALQ 712 Thielavia terrestris NRR...
Q4SHZ5            199 --------irfqppeKDEPtlEARMRRMFAggdadATARKLAGVLQTSEASRAARELLLRAHGRad 256 spotted green pufferfish
3_pfamImport       95 -------ltelsqkSLKAPtlQKEILTLIPnq--nALLQDLDAL-HNSSQIKNMVTFIEEAFKKLD 150
XP_003467922      207 -------lpelsqnSLKTPtlQKEMLMLIPnq--kVLLKDLDIL-HNSSQMKNMAMFIEEAYKKLN 262 Domestic guinea pig
EHB10238          125 -------lpelsrhSLEAPtlQKEGLMLTLnq--nVLLKDLDVL-HNSSQMKNMSVFIEEAYKKLN 180 naked mole-rat
XP_003311370      211 -------lpelsqkTLKAPtlQKEILALIPnq--nALLRDLDIL-HNSSQMKSMSTFIEEAYKKLD 266 chimpanzee
XP_005318648      211 -------lpelsqnSLKAPtlHKEILMLIPnq--nALLKDLDVL-HSSSQMKNLSMFIEEAYKKLD 266 thirteen-lined ground sq...
XP_008261250      206 -------lpqlsqnSLKAPtlQKEILTLIPnq--dALLKDLDVL-HTSSEVKNMLIFIEEAYKKLD 261 rabbit
EFB15241          159 -------lpelsqkSLKAPtlQKEILTLIPnh--nALLKDLHVL-HNSSQMKNMLTFIEEAYKRLD 214 giant panda
XP_020568795      217 --------lppvpsvTEEDalESRLRKIIPansleSTARKLGAVLQKPKANQEAQMLLTQAQKSae 274 Japanese medaka
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