Conserved Protein Domain Family
MitMem_reg

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pfam13012: MitMem_reg 
Maintenance of mitochondrial structure and function
This is C-terminal to the Mov24 region of the yeast proteasomal subunit Rpn11 and seems likely to regulate the mitochondrial fission and tubulation processes, ie the outer mitochondrial membrane proteins. This function appears to be unrelated to the proteasome activity of the N-terminal region.
Statistics
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PSSM-Id: 338583
View PSSM: pfam13012
Aligned: 294 rows
Threshold Bit Score: 29.3538
Threshold Setting Gi: 224488007
Created: 29-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6C8G3       184 EAEEI--GVEHLLR-DVRdaaagNLSVRITNQLMSLQS------------------------------------------ 218 Yarrowia lipoly...
XP_003142556 185 ESRQTtsNLGHMVKhSII-----DQLHGLGKSYYSITIsfkltvkeqqmlqslhmknw----aeglqlnsfksaaknnla 255 eye worm
ERG86256     186 ESRQTtsNLGHLVKhTIV-----EALHGLGRTYYSVTIsfkptpqeqkmlqclhqmnw----aeglmhdeyaevakrnhe 256 pig roundworm
XP_001604607 173 EPRQVtsNLGHLQEpCMQ-----SLCHGLNRLYYSINInyrkneleqkmllnlhkktw----mdgltlenysehcklnen 243 jewel wasp
XP_001604588 178 ESRQVtsNLGHLQKaCKK-----AVVHGLNLHYYSICItyrkneleqkmllnlhkktw----mdgltltkyseqskindd 248 jewel wasp
XP_004993747 173 EPRQTtsNLGHLQRpSVA-----ALVHGLNRHYYSLAInyrkneleqkmllnlhkqsw----eygltledyehhcqanek 243 Salpingoeca ros...
XP_001749839 166 EPRQTtsNLGHLERpSLQ-----ARIHGLNRHYYSLAInyrknpleekmllnlhkrpw----dhgltledfekhshdnkq 236 Monosiga brevic...
XP_002117125 173 EPRQAtsIIGHLQKpSIQ-----ALIHGLNRSYYSMVInyrkneleqkmlmklhkksw----vdglqlddykehnesnek 243 Trichoplax adha...
XP_002410756 174 EPRQTtsNLGHLTKpSIQ-----VVQWCVPRIYVPFSLflynnirmvgmamqmllnlhkkswtdgltlqdydehckvnea 248 black-legged tick
EJW82394     185 ESRQTtsNLGHLVEhSVI-----EQVHGLGKSYYSITInfkltikeqqmleslhmknw----aeglqlnsfestaqnnla 255 Wuchereria banc...
Q6C8G3       219 -LHKRLHEIANYLQKVV----------------EG---------------------Qlp-----lnHV-ILGKLQDVFnl 254 Yarrowia lipoly...
XP_003142556 256 nMQEM---------ELCalskkqhnekrtgsetEElkgteiktgkskgteskagksK---------AEsETKKVGHFDpk 317 eye worm
ERG86256     257 nMLEMVKLIKLYTKEVAn--------------------------------------EetekdlkskEElEVNKIGRLNpk 298 pig roundworm
XP_001604607 244 vVQEMLDSTKAYKKSLE---------------------------------------Deen---ltkEElAIKHVGNQDpk 281 jewel wasp
XP_001604588 249 tVQEMLELMKNYKKSLE---------------------------------------Deem---ltpEHlAIRHIGSQDpk 286 jewel wasp
XP_004993747 244 tVKEMLDLAKLYHKSVE---------------------------------------Eemt---mkpEQlAIRHHGKRNpk 281 Salpingoeca ros...
XP_001749839 237 aVEEMLKLAKLYNKSVE---------------------------------------Eems---mtkEQlAIRHTGKQDpk 274 Monosiga brevic...
XP_002117125 244 iLKDMVRLSKEYVKSVE---------------------------------------Eedk---lttEQlAIRNVGKQDpk 281 Trichoplax adha...
XP_002410756 249 tVTEMLDLAKAYNKSLE---------------------------------------Eedk---mtpEQlAIKNVGKQDpk 286 black-legged tick
EJW82394     256 nMEKMVKLIKLYNKELCmlkkpynneegtgnktEKstg----------------lsK---------AEiEAKKVGHFDpk 310 Wuchereria banc...
Q6C8G3       255 lpnvsvsssddsltdaakttderakafavksndelmivylstlvraiiAFHNLIE 309 Yarrowia lipolytica
XP_003142556 318 rh-------------------------------------------latIANDLMK 329 eye worm
ERG86256     299 rr-------------------------------------------leeTAQSMMT 310 pig roundworm
XP_001604607 282 rh-------------------------------------------leeNIEKLMV 293 jewel wasp
XP_001604588 287 rh-------------------------------------------leqKVDTLMS 298 jewel wasp
XP_004993747 282 rh-------------------------------------------lkdKIDVLMT 293 Salpingoeca rosetta
XP_001749839 275 rh-------------------------------------------laeKIDVLMS 286 Monosiga brevicollis MX1
XP_002117125 282 rh-------------------------------------------leeCVDVLMT 293 Trichoplax adhaerens
XP_002410756 287 rh-------------------------------------------leeRVDVLMT 298 black-legged tick
EJW82394     311 rh-------------------------------------------latIADNLMK 322 Wuchereria bancrofti
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