2VC9


Conserved Protein Domain Family
NAGLU_N

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pfam12971: NAGLU_N 
Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain
Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold.
Statistics
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PSSM-Id: 463762
Aligned: 135 rows
Threshold Bit Score: 64.4619
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2VC9_A          172 NEIKNLVGRVIG-ReFKDKFIFEIrDQ-LNGNDVFEVSdSGDG--KVLIKGNNGVSLASGFNYYLKNYCNVSYNPImGSN 247 
XP_002426494    671 rPAEDVLTRILGyK-KSSLFNLYId--nTTKNDGFTVI-KTPDdtKVSVSGPNAISLVWGVGFYLKNFCNVHISWD-GDQ 745 
Q9AAQ6           35 AAARASLKRLFG-R-RLAGAHLTV--TpGAERSWYAIG-GKGG--AISISGDSPVALVRGAYAHLRQAGLAHVSWE-GDR 106  Caulobacter...
jgi:Astex_3617   35 SAAEGVLRRLLG-R-EAARVRLTL-DA-SGTTPWYAAK-STGA--SVTIAGNSPVALTHGAYSYLKSAGAANLSWE-GNR 106 
WP_013568107     52 QAARALLYRQLG-E-RASQFELKL-IPlEGGNEVYEIS-AANG--RVYLAGSSAVAMCRGAYSYLRATCNVMITWS-GRH 124  Terriglobus...
WP_014266971     53 EACRGVLQRQLG-S-RAAEFDLHL-LPaVDGHEVYELS-ASGG--RVAVAGSSGVSLCRGIYIYLREHCQAMIAWS-GRH 125  Granulicell...
WP_006745382     31 AAAKRVIERQIG-K-KVNEIHFES-IEpIGGKETFDVV-AKDG--KLSIKGSSAVAICYGFHTYLKNACNSIKTWS-GSH 103  Bacteroides...
WP_025278577     32 QPAFELLERQIG-E-RASEIKLEV-IApENGKETFEIE-ARQG--VLTLRGSSTVALCYAFHTYLREACQSMKTWS-GEH 104  Barnesiella...
CCZ43333         34 KAASGVITRTLG-R-KPSNVKLVV-TGpMEGSEYFSTE-VKKG--KLTVKGSSAVAVCRGFYDYVTSNHYGLSTWT-VNN 106 
CCZ82269         24 REAREVIHRFAG-E-FPAKLKLSF-IDkENNCDVFETK-VRNG--ELEIRGSSGVALCRGFYDFIKSNHAGISAWS-GNR 96  
2VC9_A          248 LKMPET--MP 255 
XP_002426494    746 LRIPVT--LP 753 
Q9AAQ6          107 VV--QAgaVP 114  Caulobacter vibrioides
jgi:Astex_3617  107 VALPTR--LP 114 
WP_013568107    125 VELPAA--FP 132  Terriglobus saanensis
WP_014266971    126 LDLPAR--LP 133  Granulicella mallensis
WP_006745382    104 TEALDI--WP 111  Bacteroides coprosuis
WP_025278577    105 MTLPAV--WP 112  Barnesiella viscericola
CCZ43333        107 IDLPEKladq 116 
CCZ82269         97 CIFPAS--LP 104 
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