2XPI


Conserved Protein Domain Family
ANAPC3

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pfam12895: ANAPC3 
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Anaphase-promoting complex, cyclosome, subunit 3
Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.
Statistics
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PSSM-Id: 403946
View PSSM: pfam12895
Aligned: 78 rows
Threshold Bit Score: 39.5612
Threshold Setting Gi: 74691126
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2XPI_A            96 MQQQYKCAAFVGEKVL----------------DITGNPNDAFW--LAQVYCCTGDYARAKCLLTKE-DLYNRSSACRYLA 156  fission yeast
XP_001828005       8 QQERHQDILMLESPKYdkykaiahiylgefekAVTYMHNNTFE--KAYCYYKLKKFKRAFRILKKL-----QGKKVDILT 80   Enterocyto...
XP_001470964      78 NVHQYHNALKIYELIVe---------------AQPKNEKAAVL--YAKCLQLNEEYHRAIFFFRYAmEINDKLKNDAYLW 140  Tetrahymen...
XP_001747295      18 DWFLYDNACFLAERLY----------------YEAATDKATLL--LGKCYFLSGQVRRAYQVLKKC-----PLPAARYLF 74   Monosiga b...
A0EE86            26 QNHMDQNATFLAERLV----------------YERDTEEFRSL--LAECYLKENQPFKACHILRDC-----KSEFNRYQY 82   Paramecium...
A0C827            26 QNHMEQNAIFLAERLV----------------YEHDTEEHRSI--LAECYLHENQPYKACHILKEC-----KSEFNRYQL 82   Paramecium...
jgi:MICPUN_56651  29 NSYAYSNAAFLCERLH----------------AAAPTEANAHL--LATCYYRADQANRAYHTLKGR-----TSPKCRYLF 85   Micromonas...
Q06AN9            15 NHFMFTNAIFLCELLL------------------AQFPSEVNLqlLARCYLSNSQAYSAYYILKGS-----KTPQSRYLF 71   thale cress
EEF48193          14 RHFMYRNAMFMCERLC----------------AEFPSETNLQL--LAGCYLQNNQAYSAYHILKGT-----HMAQSRYLF 70   castor bean
Q54J83            14 HCGLIKNALFLSERLY----------------ASTANEDNLFK--IAQIYYQMGKINQCLLILQQH--PQITMIKNLYLL 73   Dictyostel...
2XPI_A           157 A--FCLV-KLYDWQGALNLLGET 176  fission yeast
XP_001828005      81 A--QCLY-FYGKYNDAYTLLGKY 100  Enterocytozoon bieneusi H348
XP_001470964     141 YniGLCFfKIENYTQAEQNFKHC 163  Tetrahymena thermophila SB210
XP_001747295      75 A--RCCL-DM-----RRAHLFTA 89   Monosiga brevicollis MX1
A0EE86            83 A--MSLF-QNKKYKEAEVALVGT 102  Paramecium tetraurelia
A0C827            83 A--VAYF-RIKKYKEAEMALIGP 102  Paramecium tetraurelia
jgi:MICPUN_56651  86 A--LCCV-KLRRLPEAEAALCRS 105  Micromonas commoda
Q06AN9            72 A--FSCF-KLDLLGEAEAALLPC 91   thale cress
EEF48193          71 A--ISCF-QMDLLNEAEAVLCPA 90   castor bean
Q54J83            74 A--LSNY-DLGNIQEAESSIIKC 93   Dictyostelium discoideum
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