2XPI,2C2L


Conserved Protein Domain Family
ANAPC3

?
pfam12895: ANAPC3 
Click on image for an interactive view with Cn3D
Anaphase-promoting complex, cyclosome, subunit 3
Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.
Statistics
?
PSSM-Id: 338539
View PSSM: pfam12895
Aligned: 85 rows
Threshold Bit Score: 38.0182
Threshold Setting Gi: 74691126
Created: 29-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XPI_A         96 MQQQYKCAAFVGEKVL--------DI--TGNPNDAFWL--AQVYCCTGDYARAKCLLTKEdl-yNRSS---ACRYLAAFC 159
gi 74691126    34 EDLSYDSAEFYGEIMHaecsildkSH--FYLPYYEYYY--CLALYLNGKHLVAMKAAEPYi---eRNL---ATCFVFAKS 103
gi 122315888  100 ATNRADDAVIMAREAA--------TG--AFAEDAAMMHtlALALFETGRYDEAADQLAAMqa-aHPTLrhpEAHLLHART 168
gi 122116964  279 KKKKLNELEKMIAPTS--------TF--PMEYSSEMWFvmAQYLYSTAKYDKAVYFVQKAcflnPKNA---EALILKAEI 345
gi 124462788   44 WLDNYKDAILWADKALs-------IN--SKHINSLFTK--GESLRMLGEYEDAIKILDVAlnqnPNHD---QSLVCKGAC 109
gi 124470545  127 GLGQYDEAIIWADKALq-------VD--QKHCSSLYIK--GNSLRLLKKYKEAMKVIEQSlkinPNHF---DSLKIKGAC 192
gi 124450761   69 MLGQYNEAIIWADKALq-------VN--PQHCYSLFTK--GNSLRQLKKFKEAMEVIEQSlkinPNHF---DSLRIKGEC 134
gi 918705321   21 AAAVVTAAIFVYRNMAe-------SK--REKASAALYE--AQAPFAQGKFDEAQKALEKVtnqyASTSsgqQAAVLLAQV 89
gi 938468467 1083 LRQNWEKILTQLNKASa------dVD--HLPDEHLYYY--CVALLRTDKYKELYTLYGTLsdalRNDV---RFLKIYAQA 1149
gi 255712425   29 EQNNLETAEFLAELLCset--grlARgaRERLEAAYQY--GLVLYLRGDFKSAQDVVRPFk---CESM---LCAYVLARC 98
                          90
                  ....*....|....*....
2XPI_A        160 LVKL--YDWQGALNLLGET 176
gi 74691126   104 ALALs-KHMDKAITSLLRF 121
gi 122315888  169 LEAL--GRLDEASATYDSV 185
gi 122116964  346 LLQL--KKYQEAIAHLRFA 362
gi 124462788  110 LQSL--QKYQEAINCYNQA 126
gi 124470545  193 LHDQ--SQYKEALIFMKKL 209
gi 124450761  135 LHDQ--KQYQQALIFYDKA 151
gi 918705321   90 LYEQ--KKYDEGIKALEKA 106
gi 938468467 1150 CLAL--KKTGEAIALFEAQ 1166
gi 255712425   99 ALKLdqSSWHEGARALEAL 117
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap