2XPI,2C2L


Conserved Protein Domain Family
ANAPC3

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pfam12895: ANAPC3 
Click on image for an interactive view with Cn3D
Anaphase-promoting complex, cyclosome, subunit 3
Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.
Statistics
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PSSM-Id: 338539
View PSSM: pfam12895
Aligned: 85 rows
Threshold Bit Score: 38.0182
Threshold Setting Gi: 74691126
Created: 29-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2XPI_A         96 MQQQYKCAAFVGEKVL--------DI--TGNPNDAFWL--AQVYCCTGDYARAKCLLTKEdl-yNRSS---ACRYLAAFC 159  fission yeast
Q6FWY6         34 EDLSYDSAEFYGEIMHaecsildkSH--FYLPYYEYYY--CLALYLNGKHLVAMKAAEPYi---eRNL---ATCFVFAKS 103  [Candida] gla...
Q0AP33        100 ATNRADDAVIMAREAA--------TG--AFAEDAAMMHtlALALFETGRYDEAADQLAAMqa-aHPTLrhpEAHLLHART 168  Maricaulis ma...
Q16QW4        279 KKKKLNELEKMIAPTS--------TF--PMEYSSEMWFvmAQYLYSTAKYDKAVYFVQKAcflnPKNA---EALILKAEI 345  yellow fever ...
A0BHU0         44 WLDNYKDAILWADKALs-------IN--SKHINSLFTK--GESLRMLGEYEDAIKILDVAlnqnPNHD---QSLVCKGAC 109  Paramecium te...
A0E2E7        127 GLGQYDEAIIWADKALq-------VD--QKHCSSLYIK--GNSLRLLKKYKEAMKVIEQSlkinPNHF---DSLKIKGAC 192  Paramecium te...
A0DXI2         69 MLGQYNEAIIWADKALq-------VN--PQHCYSLFTK--GNSLRQLKKFKEAMEVIEQSlkinPNHF---DSLRIKGEC 134  Paramecium te...
WP_052574321   21 AAAVVTAAIFVYRNMAe-------SK--REKASAALYE--AQAPFAQGKFDEAQKALEKVtnqyASTSsgqQAAVLLAQV 89   Gemmatimonas ...
WP_054628572 1083 LRQNWEKILTQLNKASa------dVD--HLPDEHLYYY--CVALLRTDKYKELYTLYGTLsdalRNDV---RFLKIYAQA 1149 Cronobacter s...
XP_002552495   29 EQNNLETAEFLAELLCset--grlARgaRERLEAAYQY--GLVLYLRGDFKSAQDVVRPFk---CESM---LCAYVLARC 98   Lachancea the...
2XPI_A        160 LVKL--YDWQGALNLLGET 176  fission yeast
Q6FWY6        104 ALALs-KHMDKAITSLLRF 121  [Candida] glabrata
Q0AP33        169 LEAL--GRLDEASATYDSV 185  Maricaulis maris MCS10
Q16QW4        346 LLQL--KKYQEAIAHLRFA 362  yellow fever mosquito
A0BHU0        110 LQSL--QKYQEAINCYNQA 126  Paramecium tetraurelia
A0E2E7        193 LHDQ--SQYKEALIFMKKL 209  Paramecium tetraurelia
A0DXI2        135 LHDQ--KQYQQALIFYDKA 151  Paramecium tetraurelia
WP_052574321   90 LYEQ--KKYDEGIKALEKA 106  Gemmatimonas aurantiaca
WP_054628572 1150 CLAL--KKTGEAIALFEAQ 1166 Cronobacter sakazakii
XP_002552495   99 ALKLdqSSWHEGARALEAL 117  Lachancea thermotolerans CBS 6340
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