4UI9


Conserved Protein Domain Family
zf-ANAPC11

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pfam12861: zf-ANAPC11 
Click on image for an interactive view with Cn3D
Anaphase-promoting complex subunit 11 RING-H2 finger
Apc11 is one of the subunits of the anaphase-promoting complex or cyclosome. The APC subunits are cullin family proteins with ubiquitin ligase activity. Polyubiquitination marks proteins for degradation by the 26S proteasome and is carried out by a cascade of enzymes that includes ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s). Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo. In Saccharomyces cerevisiae this RING-H2 finger protein defines the minimal ubiquitin ligase activity of the APC, and the integrity of the RING-H2 finger is essential for budding yeast cell viability.
Statistics
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PSSM-Id: 289620
View PSSM: pfam12861
Aligned: 5 rows
Threshold Bit Score: 132.223
Threshold Setting Gi: 835018994
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4UI9_B   1 MKVKIKCWNGVALWLW-VAN-----------------DENCGICRMAFNGCCPDCKVPGDDCPLVWGQ-CSHCFHMHCIL 61  human
Q5ACJ8   1 MKVEIVEWKSYCTWHWdLASsdg------------yvDELCGICRVSYDGTCPNCKYPGDQCPIVLGSgCTHNFHLHCIL 68  Candida albicans
Q4WAI0   1 MKVTIKEWNAVATWRWdMPE-----------------DDVCGICRVQFDGTCPTCKFPGDDCSLLLGK-CGHSFHMHCLM 62  Aspergillus fumigatus
Q12157   1 MKVKINEVHSVFAWSWhIPStsdedaanndpigndedEDVCGICRASYNGTCPSCKFPGDQCPLVIGL-CHHNFHDHCIY 79  Saccharomyces cerevis...
Q9UT86   1 MKVKILRYHAIANWTWdTPK-----------------DDVCGICRVPFDGCCPQCTSPGDNCPIVWGK-CKHIFHAHCIQ 62  Schizosaccharomyces p...
4UI9_B  62 KWLHAQQVQQHCPMCRQEWKFKE 84  human
Q5ACJ8  69 KWLEQETSKGLCPMCRQIFTFKE 91  Candida albicans
Q4WAI0  63 TWIQQESSKGLCPMCRQSMYTAA 85  Aspergillus fumigatus
Q12157  80 RWLDTPTSKGLCPMCRQTFQLQK 102 Saccharomyces cerevisiae S288c
Q9UT86  63 NWLATSGSQGQCPMDRQTFVVAD 85  Schizosaccharomyces pombe 972h-
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