4UI9


Conserved Protein Domain Family
zf-ANAPC11

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pfam12861: zf-ANAPC11 
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Anaphase-promoting complex subunit 11 RING-H2 finger
Apc11 is one of the subunits of the anaphase-promoting complex or cyclosome. The APC subunits are cullin family proteins with ubiquitin ligase activity. Polyubiquitination marks proteins for degradation by the 26S proteasome and is carried out by a cascade of enzymes that includes ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s). Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo. In Saccharomyces cerevisiae this RING-H2 finger protein defines the minimal ubiquitin ligase activity of the APC, and the integrity of the RING-H2 finger is essential for budding yeast cell viability.
Statistics
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PSSM-Id: 289620
View PSSM: pfam12861
Aligned: 5 rows
Threshold Bit Score: 132.223
Threshold Setting Gi: 835018994
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4UI9_B        1 MKVKIKCWNGVALWLW-VAN-----------------DENCGICRMAFNGCCPDCKVPGDDCPLVWGQ-CSHCFHMHCIL 61
gi 74656491   1 MKVEIVEWKSYCTWHWdLASsdg------------yvDELCGICRVSYDGTCPNCKYPGDQCPIVLGSgCTHNFHLHCIL 68
gi 74666541   1 MKVTIKEWNAVATWRWdMPE-----------------DDVCGICRVQFDGTCPTCKFPGDDCSLLLGK-CGHSFHMHCLM 62
gi 55976294   1 MKVKINEVHSVFAWSWhIPStsdedaanndpigndedEDVCGICRASYNGTCPSCKFPGDQCPLVIGL-CHHNFHDHCIY 79
gi 30913533   1 MKVKILRYHAIANWTWdTPK-----------------DDVCGICRVPFDGCCPQCTSPGDNCPIVWGK-CKHIFHAHCIQ 62
                        90       100
                ....*....|....*....|...
4UI9_B       62 KWLHAQQVQQHCPMCRQEWKFKE 84
gi 74656491  69 KWLEQETSKGLCPMCRQIFTFKE 91
gi 74666541  63 TWIQQESSKGLCPMCRQSMYTAA 85
gi 55976294  80 RWLDTPTSKGLCPMCRQTFQLQK 102
gi 30913533  63 NWLATSGSQGQCPMDRQTFVVAD 85
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