5G04


Conserved Protein Domain Family
zf-ANAPC11

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pfam12861: zf-ANAPC11 
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Anaphase-promoting complex subunit 11 RING-H2 finger
Apc11 is one of the subunits of the anaphase-promoting complex or cyclosome. The APC subunits are cullin family proteins with ubiquitin ligase activity. Polyubiquitination marks proteins for degradation by the 26S proteasome and is carried out by a cascade of enzymes that includes ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s). Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo. In Saccharomyces cerevisiae this RING-H2 finger protein defines the minimal ubiquitin ligase activity of the APC, and the integrity of the RING-H2 finger is essential for budding yeast cell viability.
Statistics
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Aligned: 6 rows
Threshold Bit Score: 131.452
Threshold Setting Gi: 1032214332
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5G04_B                      1 MKVKIKCWNGVATWLW-VAN-----------------DENCGICRMAFNGCCPDCKVPGDDCPLVWGQ-CSHCFHMHCIL 61  Su...
WGS:AACQ:CAALFM_CR10610CA   1 MKVEIVEWKSYCTWHWdLASsdg------------yvDELCGICRVSYDGTCPNCKYPGDQCPIVLGSgCTHNFHLHCIL 68  Ca...
Q4WAI0                      1 MKVTIKEWNAVATWRWdMPE-----------------DDVCGICRVQFDGTCPTCKFPGDDCSLLLGK-CGHSFHMHCLM 62  As...
Q9NYG5                      1 MKVKIKCWNGVATWLW-VAN-----------------DENCGICRMAFNGCCPDCKVPGDDCPLVWGQ-CSHCFHMHCIL 61  human
Q9UT86                      1 MKVKILRYHAIANWTWdTPK-----------------DDVCGICRVPFDGCCPQCTSPGDNCPIVWGK-CKHIFHAHCIQ 62  Sc...
Q12157                      1 MKVKINEVHSVFAWSWhIPStsdedaanndpigndedEDVCGICRASYNGTCPSCKFPGDQCPLVIGL-CHHNFHDHCIY 79  Sa...
5G04_B                     62 KWLHAQQVQQHCPMCRQEWKFKE 84  Sumatran orangutan
WGS:AACQ:CAALFM_CR10610CA  69 KWLEQETSKGLCPMCRQIFTFKE 91  Candida albicans SC5314
Q4WAI0                     63 TWIQQESSKGLCPMCRQSMYTAA 85  Aspergillus fumigatus
Q9NYG5                     62 KWLHAQQVQQHCPMCRQEWKFKE 84  human
Q9UT86                     63 NWLATSGSQGQCPMDRQTFVVAD 85  Schizosaccharomyces pombe 972h-
Q12157                     80 RWLDTPTSKGLCPMCRQTFQLQK 102 Saccharomyces cerevisiae S288C
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