4AI6,6ZYW,6ZYW


Conserved Protein Domain Family
AAA_9

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pfam12781: AAA_9 
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ATP-binding dynein motor region
This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Statistics
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PSSM-Id: 463702
Aligned: 379 rows
Threshold Bit Score: 155.679
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4AI6_B              1980 MKWlE-CGLDKNDYFLENMSIVMns------qDAVPF-LLDPSSHMITVISN---------Yygn--ktvLLSFLEegFV 2040 Schist...
EGT57668             799 LNWkT-KGLPADQLSLENGMIMFn-------sCHVPL-IIDPSGQVSTFLSKfle------------kseTFKAAQsdLI 857 
XP_001328083         586 LEMkH-NGFPSDDLSVENAQIIQi-------sTQRPLfVIDPTEHVVEWLQSvlgp-----------saeVLSSSHprFQ 646 
Q0E8P6              3136 IIWeS-QGLARDAQIIESAALLRemlslpygaCPIPL-LLDPTQTAAAWLMAhlkgs--------grpceLTTHGNdrLP 3205 fruit fly
XP_002003478        3193 IIW-EsQGLARDAQIIESAALLRemlalpfgsCPVPL-LLDPTQTAGQWLSAhlratgrasE--------LTSQGNerLC 3262
WGS:AAQB:GK18215-PB 3191 IIW-EsQGLARDAQIIESAALLKqilelpfgsCPVPL-ILDPSQRVTTWLMVylksenracE--------LSSHGNerLA 3260
jgi:MICPUN_96530    3212 LTWkS-EGLPGDELSMENAIVILn-------sAQAPL-IIDPSTQASQWLKAh-------vAkdeksaleVVTMHDkrFA 3275
CBN76243            2781 LVWkG-EGLPADDLSQENALVLAns------pGRVPF-IIDPANACTAWLQSf-------lAkdasrpleVVSAADarFT 2845
EEY61986            3312 LTWkS-MGLPSDNLSMENALIVSns-----sgERCPF-IIDPASASTAWLQAe-------lAkdttrplsIVQSQDarFV 3377
XP_002604212        4062 KQL-ElQGLPTNPVALDSSCFVTetl----snNSWVL-LCDPTSRAIPWLTDy-------lKeg----fiISKYHD---L 4121
4AI6_B              2041 KR-LENAIRFGSVVIIQDGEFF----DPIISRLISREFNH--AGnrVTVEIGDhE-VDVSGDFKLFIHSCDPSGD-IPIF 2111 Schist...
EGT57668             858 TQ-IELAIRFGKTIIIDDVVEF----DPCLIPILRKDLSS--QGprQVISFAG-KsIDFNPDFRIFICTRDDKVE-IRPN 928 
XP_001328083         647 HQ-VTLAIRFGKKLIIREADKV----PLCLYPFLNREFVM--SNghLTVCVGD-KfIDVHPDFRLIIVTRDAAIK-LTAR 717 
Q0E8P6              3206 YQ-LELAVRFGKTLLVTDCEQL----RPPVLQLLQGHVFV--RFnkRQLAIGS-KlVDLHESFQLVLISKSHRLD-LPEE 3276 fruit fly
XP_002003478        3263 YQ-LELAVRFGKTLLVLDCEQL----RPPLLELLQLHIYVr-FNk-RQLAVGN-KlVDLHEDFQLVLISKSHRLQlLPPE 3334
WGS:AAQB:GK18215-PB 3261 YQ-LELAVRFGKILLVTDCDQL----RPPLAQLIQGHIYMk-FNk-RQMAVGS-KlIDLHENFQLVLISKSQRLA-LPKE 3331
jgi:MICPUN_96530    3276 NK-LELAVRFGKTLIIEEVDKI----EPILYNVVRKDFER--QGlrLMVQVGD-KtVDYNESFRMYLVTRNPYPV-IPPS 3346
CBN76243            2846 SR-VELSVRFGKTLLVLECDGV----EPMLYPLIRQDLVH--QGprYVVQVGD-KlMDYNENFRLFMVTRNPKPE-LPPD 2916
EEY61986            3378 NL-VEQSVRFGKTLVILEVDNV----EPYLYPLVRKDLIH--QGprFVVALGD-KvIDYNENFRLYLVTRNPSPP-LAPD 3448
XP_002604212        4122 KSqLETCLTEGLFLILTDIDLHllakDNRFNHVFRRRMSFltGKapFKIIVGS-HeVECRPGFRLYMHTTCM-PHeVPEE 4199
4AI6_B              2112 LRSRVRLVHFVTNKESIETRIFDITLTEENAEMQRKREDLIKLNTEYKLKLKNLEKRLLEELNNSQGN-MLENDELMVTL 2190 Schist...
EGT57668             929 CSVQINIVNFTTTISALSAQLLDVAIHLEKPELEERSSSLLRDAELKKLELEDLEQLLLQQLASSQGN-LLENTALLDSL 1007
XP_001328083         718 EKSLVSLVNFTVTKTALKAQLLTLALTTEMPELEEKHQEQLNESEQLKIELGKLEEGLLEILGKANPDtILQNKELIQSL 797 
Q0E8P6              3277 QRSQLNVLKFTVTAAGLADQLMSKAIVLKNGELEQQRIELLQKEGHLLKQRMEMQDKLLEQLSKSEGD-ILKNEQLLESL 3355 fruit fly
XP_002003478        3335 QRGQVNLLRFTVTATGLADQLMSKAIVLKNPALEQQRIELLQREGELLKQRMALQDKLLEQLSKAEGD-ILRNEPLLASL 3413
WGS:AAQB:GK18215-PB 3332 LASQVNQLRFTITAAGLTDQLMSQAIVLKNPKLEQQRIDVLQREGDLLKQRMELQDKLLEQLSKSEGD-ILKNEILLATL 3410
jgi:MICPUN_96530    3347 AASIISEVNFTVTRSGLEGQLLGLVIQHEQPELEKQKSHLLQVEEDLKVQLAGLEKTLLETLATSTGN-ILENEQLITSL 3425
CBN76243            2917 ASALVCEVNFTVTRSGLEGQLLGVTIQHEQPELEKAKSEMLRQEEGFKVRLADLEKGLLEALATAEGD-LLEDTSLIERL 2995
EEY61986            3449 ALAIVNVVNFTVTKSGLEGQLLGVTIQHEQPELEQEKSELLRQEEDCKVQLAALEKQLVEALATSEGD-ILENTMLVESL 3527
XP_002604212        4200 VAAYTSLVNFYQDRSGIEAELLDRFIRLEKTRVQDERTNLAQEKIGNMERLALLEDQMLNLL--------ASDTRLLNNL 4271
4AI6_B              2191 NNLKKEAMNI 2200 Schistosoma japonicum
EGT57668            1008 NKSKESAEII 1017
XP_001328083         798 DDKKKRAVDV 807 
Q0E8P6              3356 NEIKQGSTQI 3365 fruit fly
XP_002003478        3414 NEVKRSSAEI 3423
WGS:AAQB:GK18215-PB 3411 NEVKESSKQI 3420
jgi:MICPUN_96530    3426 DETKAKGTTV 3435
CBN76243            2996 SETKTTAAEI 3005
EEY61986            3528 TKTKATSAEI 3537
XP_002604212        4272 AVTKKLADMK 4281
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