Conserved Protein Domain Family
AAA_8

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pfam12780: AAA_8 
P-loop containing dynein motor region D4
The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
Statistics
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Aligned: 32 rows
Threshold Bit Score: 305.258
Threshold Setting Gi: 557137608
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBJ26589     2386 MSLVFFPDAVRHLLRISRILRQPRGNAMLIGLAGSGRESLVHLATSMAGSTLV---RVNVTHDYGIQK--FEQDLKNAVL 2460 Ectocarpus si...
KRX01504     1649 IKMSLFLQIIEIIVKTCRVISQDKGHQLLVGINGCGKKSISKIASKLLKQKF-----ITVIETQSQKV--FREQILEVMK 1721 Pseudocohnile...
4_pfamImport    1 LDMVLFNDALDHLIRIHRMLRMDRGHVLLIGSNGNGKKSLSKLAAFTSGYEIFinnSFHSKHNFKMNEqkFKHDLKNIFL 80  
ESN96268     2635 ISLVLFDDALEHLNRINRVLLLPKGHCLLMGLGNVGKFSLAKLAACIAGLEIF---TIELARGYSEAS--FKEDLKILYD 2709 Helobdella ro...
Q4CQ59       1396 MDLVMFDMALDHLLRITRVLSLPRGNCLLIGVGGSGKQSLTKLAAAMYRMGVF---EIVLSRNYNEDA--FREDLKRLYA 1470 Trypanosoma c...
EST42199     2877 IDLVLFDSCMQHITRLTRILFSQNSHALLIGVGGSGKQSVVKIASHITGFKLI---QIQATKNYNLQN--FDDDLRKIGR 2951 Spironucleus ...
EFN89651     2249 IDITLFRYALQHLARICRVLAIPCGNLLMVGTGGSGRQSLTRLSSAIAGYGLR---QPEITGTYGMQE--WREDVKWVLK 2323 Jerdon's jump...
EFA11266     2015 IDLVLFDHALEHLSKICRILSIPYCNLIQVGMCGTGRQTLVKLACLIMNQNFF---KIEITEKYKLDD--WHRTVKAFLK 2089 red flour beetle
KOX75896     2119 IDIVISQYILECLIKISRILIIPGSNLLIISSMGSGRKSIASLAAYIQQQELF---EPSVQSYCDFNM--WRKDIKMVLR 2193 Melipona quad...
1_pfamImport    1 INVVLFEFLVEFLIKIHRLIKQPFSHGILIGIEGSGKHQLSQMACFLANFQLY---EIRLEANYTTDD--WQQDLKNMLQ 75  
CBJ26589     2461 TAGIDTKHTVFLLKDAQILDEAMLEDINCLLGSGEVPNLF-TPDEEADIVIRVRDA------VRATgk----pDT-RARS 2528 Ectocarpus si...
KRX01504     1722 YAGLEQKHITYYVEDNGNIDTNFFEDINSLLHTGEIPNTL-NKEELQIIQNTLQDEnidilqNQQ-----------KNSV 1789 Pseudocohnile...
4_pfamImport   81 KVGIKNQPTVFIVDKVDVIEEGILEFINNILTNGFVPSLYlDQKENLEMVQRFKDIni--------------nTS-SEIT 145 
ESN96268     2710 KICIQNLKVAFLFKDQYIVEENFLELINNMLTLGTVPSLF-DDEETEKIMEAFQRD------LPGYek----aPT-KEIF 2777 Helobdella ro...
Q4CQ59       1471 RVGVQKEKVVFLFTDSHVKEEGFLEVINNMLTSGMVPALF-TEEEKEPLYSSVAAE------VEADgl----aPS-KDNK 1538 Trypanosoma c...
EST42199     2952 EAFFE--DIIFRFTDNDIKNEMFLERINNLLTVGEVPGLY-AKDEREEIISDARSI------FKKEcpr--qsDT-NDSL 3019 Spironucleus ...
EFN89651     2324 NSGGVGKDFVFLLAEEQIRDDAFLDDVDSLLNDGEVPNIF-NIEERQEIIEMTR--------LAAQggdrnldIS-VLNV 2393 Jerdon's jump...
EFA11266     2090 EAGGYGRPCTFFLKEGQIVIDTILDDLNYLLKSGEIPFIY-SLEEKQELLDVVR--------ASMQeeqpnidES-SESI 2159 red flour beetle
KOX75896     2194 KCGELRQDFILFLKDKQV-KHNFLQDICCLLATGEISDLF-SAEEKCNIIETIR--------LHAQngnkneeIS-NDAV 2262 Melipona quad...
1_pfamImport   76 LAGVDHKEVVFHLKHNEIIKEDFLDDINTLMNNGEIQGLF-TKEEYENIISQTNMR------AAGSinsdknnTAnNQII 148 
CBJ26589     2529 MAFFTAQVRDHLHIILCLDPSGATFRERIRNFPSLVNCSTIDWYNAWPKTALHSVAHRVLTEl---ALVPSGPHEcgvgp 2605 Ectocarpus si...
KRX01504     1790 REKFSKNVLQYLHIILGFSPIGPDLRQNLRKYRNFVNQTTIKWIQPWPEEALLSISKSFFDEnlmfEGIDQKIKM----- 1864 Pseudocohnile...
4_pfamImport  146 TDMFLKNCLNNLHIVLLMSP-GNNLRLIFRNYPGFVNKTYVDWINKWPVEALNAVVEKVLINd---QVIPDVYVN----- 216 
ESN96268     2778 WHNFAKRANTNLHIILSMAANNEELPKRCRNFPGLVSNTNIDWVFPWPSQALLAVATSFISDe--tNIIPVNHQT----- 2850 Helobdella ro...
Q4CQ59       1539 WTAFVARCRDNLHVVLSMSPSGNILRTRCRNFPSLINNTTIDWFQKWPSQALEAVGNRMLQE----EEVSEDLKR----- 1609 Trypanosoma c...
EST42199     3020 WRFFLNKMKQQLHLVLSFSP-GLLFRERCNKYPGIISGCIIDYYREWSLDALQQVAGHMI-----------NQGD----- 3082 Spironucleus ...
EFN89651     2394 LAFFVGRCREKLHIMLCLSPIGDAFRIRLRMHPGLVNCCTIDWFDVWPEDALEQVARRTLVD----LELAENVKD----- 2464 Jerdon's jump...
EFA11266     2160 FLYHQKRCKENLHIIFSFNSANSKFRDYIKQYSSLRKFCEINYLKKWPKEALESIAKVWIQD----LNINDETKS----- 2230 red flour beetle
KOX75896     2263 MNFFLEQCRNKLHIIFCFRDVNKNIRSYLYKYPELIKYCTINWYEMWPTDTFLQVGLKYIED----INIEENVKI----- 2333 Melipona quad...
1_pfamImport  149 LAEFSQKCRENLKILLNFTPTGANLRSRIRNYKSIVNCSTIVWMDSWPTEGYKEVAETLLKE------EDVVNRD----- 217 
CBJ26589     2606 klaaALIRTSVEVHGGVEPAAASFFSQLGRRIYVSPKSFLDFLRTFLNI 2654 Ectocarpus siliculosus
KRX01504     1865 ----QICNFSVEIHKSAIEKSKEYERMWKRKIYITPRNYIQFLKTYISL 1909 Pseudocohnilembus persalinus
4_pfamImport  217 ----NVIKQSVYMHKSAENYAKTFFKHTTRKICFTLKHLVDCAQTYKNL 261 
ESN96268     2851 ----DVIQIAIYVHFSAIQASVNFWEKQRRRNYISPKNYLDFLATYIKL 2895 Helobdella robusta
Q4CQ59       1610 ----AIASHAVYVHLTADELSMRFLGEMKRHNYVTPKNFLGFLANYSRL 1654 Trypanosoma cruzi
EST42199     3083 ----NLNICLSQVHSFVYEIIQKYSEETSRKTNITPKSFLSFLTIYKDI 3127 Spironucleus salmonicida
EFN89651     2465 ----ESVVACKFFHSCTKDVSARFYELTGKKTYVTTASFLDLMRMFADL 2509 Jerdon's jumping ant
EFA11266     2231 ----KVVNAFSYFHQEGEQI--------SNGVHVTPGSYLEFIRLYVDL 2267 red flour beetle
KOX75896     2334 ----NVIKVCIQLHNHMQKISTEYYKESNTKIHVTLTAYLHMLKLYVYL 2378 Melipona quadrifasciata
1_pfamImport  218 ----VILEIAISIHMETINMAKNYFAETQHYLYITPHSFTDFINTYKEL 262 
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