Conserved Protein Domain Family
phiKZ_IP

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pfam12699: phiKZ_IP 
phiKZ-like phage internal head proteins
Phage internal head proteins (IP) are proteins that are encoded by a bacteriophage and assembled into the mature virion inside the capsid head. The most analogous characterized IP proteins are those of bacteriophage T4, which are known to be proteolytically processed during phage maturation, and then subsequently injected into the host cell during infection. The phiKZ_IP family consists of internal head proteins encoded by phiKZ-like phages. Each phage encodes three to six members of this family. Members of the family reside in the head and are cleaved during phage maturation to separate an N-terminal propeptide from a C-terminal domain. The C-terminal domain remains in the mature capsid. The N-terminal propeptide domain is either mostly or completely removed from the mature capsid. In one case, an unrelated polypeptide is embedded in the propeptide and also remains in the mature capsid. The phiKZ-like IP proteins are not discernibly homologous to the T4 IP proteins, and it is not known if the phiKZ-like IP proteins are injected into the host cell, or have some other function within the head. The alignment and HMM model exclude most of the propeptide region, but include the cleavage sites. The first 100 residues, including the cleavage sites, constitute the most conservative part of the seed alignment.
Statistics
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Aligned: 14 rows
Threshold Bit Score: 194.544
Threshold Setting Gi: 122150909
Created: 25-Mar-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8SD67       208 AGingiSQSTAAFIHSALLPHRHVLg-DNTLTS--S--LENYTTGGKSHLYPVKi----STEDIKELSRKALAYIKKAIA 278 Pseudomonas vir...
Q2Z118        81 SGq--fSSVGFAHSYNKALRLNAKLggQSFERL--G--AESISDAATAKIASVT-----GVEAFMDTVKNAGKKAAEFIK 149 Pseudomonas pha...
Q8SD70        34 LLp------SIEDIQSRLECTEKDI--LVKTYT--DglFQKYADNQDVVSEHILktenvSLEDLSKTARNTWDEMKKSQA 103 Pseudomonas vir...
Q2Z120        51 QRtl-nTLEAHEVTPELAEQLDKELiaAEALPE--A--VEGAEALGFTLLPKAYla--tRLAGCESFLSDFFKSSREVVS 123 Pseudomonas pha...
YP_001956880  56 AGpdglDHVAKHFMLVGLQQLK-----VRKNST--G--MESFDADRETv----------TVEDFSEWLSNLGERIKQLIN 116 Pseudomonas pha...
YP_001956878  31 ldlyakRNDAICDEMAALENLFITLegSDPTLInyA--LEKYNLTEVv-----------SNEDVNRAAIQAWERVKVNLR 97  Pseudomonas pha...
YP_001956970  17 TGklfaSLERYQAILGDEEVSSEDV--AFVMST--A--LENIDPEFDIKEGSTi-----TLRAIKEALVAAAKVAWEILK 85  Pseudomonas pha...
NP_803729     21 VEayrhRLARYQDLLDGRDVASEDL--SKAMSF--A--LESIDPAFSIKEGGIi-----TLRALKDALVRAAKAARDIVR 89  Pseudomonas vir...
YP_001956879 282 RAnpriSKQAAAVLHASLENIDQMCg-LKIRAT--G--FESYEATPRAALEATAv----DGDSLSSRAAEIGAKIMKVIT 352 Pseudomonas pha...
YP_001956881 154 TGangvSNQTAEVIQSQLRSINRRLg-VESKFV--S--TESFIARDNREQHAIAt---iALEDIKTSVKVAKNKFIELLE 225 Pseudomonas pha...
Q8SD67       279 KLREIISHVWDSLKNSVPRVSVKVDELILAIQN------A-KFENIPSELTVPvkngG-PVFANGKF------------- 337 Pseudomonas vir...
Q2Z118       150 AIFNTVINFFVGLFSTAAGIDRRRAQLADKLGK------A-DKLKEKIKLGKWni-gV-DYAKNGAD------------- 207 Pseudomonas pha...
Q8SD70       104 KHRDELKEYARVITQGNQRTLERINMLLERAEN------I-KHEPFKQELKFKn--tK-RFSIDGKF------------- 160 Pseudomonas vir...
Q2Z120       124 LIGTFFRDSYVLFMESQESLSKQIDLLETRLSS------V-----------------E-KFGSQGTF------------- 166 Pseudomonas pha...
YP_001956880 117 KLIALAKQAASKIMSGIEGVKTQSEELMERARKsarrpsN-ERHGEGKEITIDs--pS-LLWTDGEF------------- 179 Pseudomonas pha...
YP_001956878  98 RFQSDLFGYAKVIQSGSERLVERLEMLQGIAEK------A-NKVPFKDEITVKk--nQ-KFAINGGF------------- 154 Pseudomonas pha...
YP_001956970  86 QIYQYLNALYVRFTGSIRRVRGNQVRVMRRLAS------LgSKTSYSSTINVAg--lQ-RLSVDGKFvgidmsnlqdika 156 Pseudomonas pha...
NP_803729     90 MVIETLTAFYVKFTGSISHVRKTQQKLSRRLAK------L-GNRTTNTRLTVSg--lQ-RLSINGEF------------- 146 Pseudomonas vir...
YP_001956879 353 ALYEKLKLYAARYSTGIDKLSDRFTTIARKAPS------G----IELKSITIRgd-rS-ELFLDGEF------------- 407 Pseudomonas pha...
YP_001956881 226 KILALFKRAASNWLDGLVSLDKKVDQLDQRLGA------L-KKPGGGGSLTLHn--aGlVVYKDSID------------- 283 Pseudomonas pha...
Q8SD67       338 I-------------QPSANVGYGPIVKWMASVYAKDYATYLTNIGTvLKAWDPERNDASELVEKMDKLQ----------- 393 Pseudomonas vir...
Q2Z118       208 IldkgpftkvlsdsLPAFIDIGKNLDGVNASQFKTAYNSLVADVKAvVKETGGNATEKGSGDKRQVLAA----------- 276 Pseudomonas pha...
Q8SD70       161 E--------------PTTVDPILMQVNNLIAFYDKSLLLYIQSVADiLRKLSFDEKWTDRAAQDFSKFN----------- 215 Pseudomonas vir...
Q2Z120       167 I-------------LGHRLFNRFKINGKVDENWSGNLTKLNQTLSGlSNNYYLNSK--NALAASFSYFG----------- 220 Pseudomonas pha...
YP_001956880 180 C--------------VGDCKSEQNVVKFFVGAWPKYAIDQIQRAKKmISEYDVESGNSDNFESNMGFIG----------- 234 Pseudomonas pha...
YP_001956878 155 --------------QPFDIRPVLEDTNNTFDFYDKVLLPYMKQIGKlLDTVELNLTWTENTEMRFELLNankwmknfkpl 220 Pseudomonas pha...
YP_001956970 157 I-------------ANYTLTVYPRCVTQIARNASRQFLNLLDTANG-ENNKEVSKQLIEVLSEIFERNF----------- 211 Pseudomonas pha...
NP_803729    147 IgdrpdnlldikevTNYILMTYPKMTSNIARNISRQALNILDNQGE-DTTTEIIDELLQSFADIVRRDF----------- 214 Pseudomonas vir...
YP_001956879 408 V-------------GDYLTPEERKIPELLKQNRKELAKLLVKPLERlLSSGPADERMLNDIEQIKQAIG----------- 463 Pseudomonas pha...
YP_001956881 284 I-----------------PEDIPGLAHFASVAYPDVVTKYLDQSAKtLLKYKPSDFDPERIKEEFERHA----------- 335 Pseudomonas pha...
Q8SD67       394 ---D-----------------------------------GP---------LKHYASTSNTLPGNKLVTTTATQVYlt--- 423 Pseudomonas vir...
Q2Z118       277 ---R-----------------------------------AG---------FGIYLTFEEKVDTDEEVLAAARSIKlsf-- 307 Pseudomonas pha...
Q8SD70       216 ---Vknwmkgav--------------------pikkddrFR---------VSSTVYRSMPVQGNKTLFGAGPTETqteei 263 Pseudomonas vir...
Q2Z120       221 ---GfagltqvevderlcmmpvslpstpfkectypdkrrSG---------PNVVAKRSVELMGGAYFYDVRSTVKpvilk 288 Pseudomonas pha...
YP_001956880 235 ---N-----------------------------------HQ---------SLVATVTRDILPGNKQIAFKYVALGpe--- 264 Pseudomonas pha...
YP_001956878 221 eepDd---------------------------------rFR---------AAAYVVRGITAQGERAIYYSGPEDTktenv 258 Pseudomonas pha...
YP_001956970 212 ---Reppdssd----------------------vrqgeiGG---------QTKFLKRSTALVGNSAFVYTDPRVIgn--- 254 Pseudomonas pha...
NP_803729    215 ---Ka---------------------------------pPGdeplkkgetTSTGTHRSYILPANRAFVYTDADHIatsvt 258 Pseudomonas vir...
YP_001956879 464 ---G-------------------------------------------------TGERSTSIPGGYKVTAKGIDId----- 486 Pseudomonas pha...
YP_001956881 336 ---Kp---------------------------------lAY---------LIELQVEKDELPGGQHLDVDEGGLSf---- 366 Pseudomonas pha...
Q8SD67       424 ------------------nDETAAEPG--------------------TE--------VTLKNFDKSqAKKEAVALRNLVD 457 Pseudomonas vir...
Q2Z118       308 -----------------gkNKDASEFA--------------------KGe-------AAVKATKAQ-LESLLKTVSSTVS 342 Pseudomonas pha...
Q8SD70       264 rdwdflvntvrdfafkfytIPTMKDAL--------------------EGn-------NTFKVNDTSsIGRRLVLLSEMAK 316 Pseudomonas vir...
Q2Z120       289 npddi-----qdfviryteIDHTGFDN--------------------NEeytlrdvgAEVKALSSEdIKTVIKLLRQLLK 343 Pseudomonas pha...
YP_001956880 265 -----------------lvDAEDAQPA--------------------PDk-------HSFEIRTLVeITSTLKQNVATMN 300 Pseudomonas pha...
YP_001956878 259 kdwgyfistirnmryrylkIPGQQPLN--------------------ESd-------NKIDVENATtIRQRLSYLIGIAK 311 Pseudomonas pha...
YP_001956970 255 -----------------efGKTNGNAAdtvasalhmnfqelslnvadKSe-------REIELPTVRdLTQLTEEISRILT 310 Pseudomonas pha...
NP_803729    259 nkqsalemvrntftmefteLQINAIDS--------------------TE--------RDIEVPSVTtLSDIVTGIANILT 310 Pseudomonas vir...
YP_001956879 487 ------------------vVEDKADRG--------------------ADe-------VTVEPMMGHeLGRSADDIKRYLA 521 Pseudomonas pha...
YP_001956881 367 ------------------gIKGEVPAG--------------------VDk--------EVDLETTVeLRKKVRAIKDIVE 400 Pseudomonas pha...
Q8SD67       458 DAADVITGGRNIV-------KAIKQLEDDVDqlsrkleSDKI------DDVSKEQIEEVSRKVASIITDSAPKHDSII 522 Pseudomonas virus...
Q2Z118       343 VLKDSKISQKFSKae----rDRVVGTLNAKG-------GDKD------AKAGTDKAIKLVRALYSTGASLTQSVNRLL 403 Pseudomonas phage EL
Q8SD70       317 RIDARKDYATKLDfe----fGRLMQLAETNRqqagrirAQQSnmrnrqAKVQDPDAPDGIPAISNIINSITLMINNVS 390 Pseudomonas virus...
Q2Z120       344 DWGKVFEMAETYRvtdsdynDIIKGFLEADI-------SDEA------KTVLSKTFAKVVRKNQTELLGIRAEVSNYL 408 Pseudomonas phage EL
YP_001956880 301 ALGQMYRSESEVLt-------eMATLADALMkle-grrGETV------WKSARDGLDDISKAMMDLIGRLKPNYDPIV 364 Pseudomonas phage...
YP_001956878 312 RIQGRKGYDQKISte----lRKIERSADKVRnntrnmrTQLD------QRNVEEERDEGRPNVSNIVKDMSTILNCMT 379 Pseudomonas phage...
YP_001956970 311 IAEKAESGRRDFNsvktvvdDAIRQAMDSTEnkavipvAQTV------MTVLGEVSKKLAEPMDNFMHWLAITLNVWL 382 Pseudomonas phage...
NP_803729    311 IAERAKQGEVEYKtvkvvvdDSIRQLAERSEllg-ranGEAI-------NMLAEISRKLAEPVGNYTHWLAVTLKVWL 380 Pseudomonas virus...
YP_001956879 522 LLLGVIDEATSPDe-----vERLKKAVLTLRkns-kggDEAV------FQKVQSAVVEIINKQLNPVEFMGlvgklak 587 Pseudomonas phage...
YP_001956881 401 QIKKIRPEVEKID-------KAGKRLIEAARrs---tsLKAE------DEKEAEDFYNIVHDAISRSAAAKPRVDEVI 462 Pseudomonas phage...
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