Conserved Protein Domain Family
ABC2_membrane_3

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pfam12698: ABC2_membrane_3 
ABC-2 family transporter protein
This family is related to the ABC-2 membrane transporter family pfam01061.
Statistics
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PSSM-Id: 338450
View PSSM: pfam12698
Aligned: 138 rows
Threshold Bit Score: 46.6145
Threshold Setting Gi: 501562525
Created: 29-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81531262   18 KKTLIMMLLMPIVIILi-LGNALKsvdnFSVT----NLGKTTV------YYYNADNKEISKNFDEFLKNks--ikDi-lN 83
gi 123016183  19 ISFL-IMILVPFIMLGi-IYVAGN----FAQQ----NSDVNKI------GVLADNE-QISQQMSQVKTDdf--efK---- 75
gi 81585289   19 lSFL-IMILAPFLLVGi-VYLAGS----LASG----FSGDTTI------GLVSEN-----QALVKELTKnktedfS---- 73
gi 122268912  19 WSFF-FMVISPFLMIAl-TVGISY----ASADs---AASSKQI------AVISDS----ATLRQSYLKQhat-gvN---- 74
gi 506381358  19 RAFIIMTVIISLLIIGg-ANANKI----IDMF----NGGPDKI------GIVSEN-----QQVYQMVKSqsa-kiEdkgT 77
gi 501846551  19 KSFI-FSTLFMILIFVg-LSNADKi---YDYF----DKSEDEI------TVISSSDKALATAFKESYHKld--kkK---- 77
gi 506391958  19 WSFV-LMVLSPFLFLAf-SAGIGY----VSGSs---AEKSNKI------AIILP-----QDNMKAAFKQld--hvT---- 72
gi 345284523  22 WSFL-IMVLAPFLAIGl-GLLLGK----VSSD----NAEDMVK------DVTEIAVVATSKNLQKQFESqt--nvT---- 79
gi 584607723  20 KSFILMTCLYVLVMSVavFWSEIK----ELFTg---DDEAQQI------AIIN-D---TSADLSGIFVSng--dmA---F 77
gi 524466879  19 KAFW-ISTIVIMVLLGv-MCAIPRv---MSFFdngeEGTDTKTeysgtcYLVDET--GVFEKEIEYLKAayp-gmNf--K 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81531262   84 VKKVSSYKKGKELVDKGEGN--SLIYINSNYSDnIE-------------ANKKGRIEIYE--SKSST-TRN----QIIKS 141
gi 123016183  76 --AVDSEEKAQKELSEEKID--AYLVVSTENDKi--------------------NGMLYS--ENSLG-QSTq---LLIQQ 125
gi 81585289   74 FKAVSSEKKAQEQLKDEKID--AYLLLDTTDNQ--------------------ISGQLYS--ERSLG-NATemliPQMLN 128
gi 122268912  75 -RKITQPTQAKKAMRENHLA--GYLTLSTTTDRvRAdyhgn----nslsSGIQAQVQNFL-------------------- 127
gi 506381358  78 KFQHVSEKQAIKDVKNEKLD--KAYIIKTKG-KqVEgeivskdsvsdetKQKLESILTPI--QTQAI-AKS----VNLSP 147
gi 501846551  78 KLKIVDFKKGEEGIKDETYK--YLIDIKENEDKtIE-------------------AKVYS--TEYAS-DSVm---GAVRS 130
gi 506391958  73 -FDYKDVQKAKKDLKSDKIL--AYITLSENNQV--------------------ITAKYFS--KEEPS-QSQ----KALLT 122
gi 345284523  80 -IRYESLDKAKKALNKDKIA--GYVSVSLKKGR----------------YEARYHGKGSI--DETSK-AGI----MNVLS 133
gi 584607723  78 IQDEKDIPALEKKVKDGKLD--AIVTIKDQGGQlQ------------------AEIATFTplKLNDQ-STL----SSLLQ 132
gi 524466879  89 SIEEDEVKGLEKAVDESKSRnvAILSIQEKDAApVL----------------EITVSNFL--SKVQAdTIA----DACNK 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81531262  142 L-ID---S--FNDGANTVEvssqi----srmrtSYVEKNNISKKYLSV-----NGKS--PRAIDYYSV----TMLMMILL 200
gi 123016183 126 Q-LT---G--LQSMLRASQlgispeevaslsqqASLTRQKVNFDSKGKmtvgeDNSTv-QYVVSYVAT----IVLFIIIL 194
gi 81585289  129 Q-LQ---T--MANANRLNLtaeqva---mlnqqATFKKAKISFDENGKik--tGEDN--TGIQMALAMgi-tILLFVFIS 194
gi 122268912 128 ---S---Q--YQQAQNYQDakltak---qqrllARTPVFKQHIATKAGt---tNLTR--TISFWILIT----MIYIILIT 187
gi 506381358 148 KdLQ---A--LQQQSK-------------------VTAKVVGKDAKQLs---eQDKV--ANIIILYAGi---MLMFFIIL 195
gi 501846551 131 T-LT---A--FQSNNIAQSlnlsqddlnrvmseAKVTDKVIKPKDANDn---vSEQS--KALNTALVYag-lFLIFIITI 198
gi 506391958 123 QsLN---G--LQQTLNVAKaqisp-----qqleTLSTQAKLDVQTTNH-----TNYDkiSKYISFYGVt---FIMYMILI 184
gi 345284523 134 R-LQssqNi-VAAQLNNDQlhklqvq-pnfveiKNSASKQNQIDKKQQ-----EKFA--NKTAYMILL----FVMYFILI 199
gi 584607723 133 Y-AG---QhyAVQQLS--Lspeqaa--qimaaqTTISTKNLNEESTGGks--eEEKQs-GLVVSYAVG----ILIYFFIS 197
gi 524466879 147 I-WQ---Sh-LLTENGLEK--------------GEVDAIQTPLIYTQR-----FIGN--MNLTEYVVGllltFVMFFAVY 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81531262  201 YGANYGSAELENLFFDRVGKRIKTTaTKTYQHLLGVVLGVIFTLILQA------VVLVL---FtkyVYG----------- 260
gi 123016183 195 TYAQIIAQEIASEKGTRIMEVILSS-TTAQKHFYGKLTGVLLVALTQM------ALYGI---I----FGigysqfkdm-- 258
gi 81585289  195 SYSSIIAQEIASEKGTRIMEVILSS-TKAQTHFYGKLTGVILVALTQI------FIYGVa--F---VLGysqlknldfmk 262
gi 122268912 188 YSSI-TAQEIASEKGTKIMEIIFSS-TTATSYFVGKIAGIMLVILTQI------GIYLLggwA-----Gysiavnnaalk 254
gi 506381358 196 NYANQVAMEVATEKISRVIEMVITS-ISPVKHLLAKILAIILVAFTQV------LIFVV---Vg--AISiylsdlrdiv- 262
gi 501846551 199 NYGSQIATEIAQEKSSRVIEMIITS-ISPITHLMAKILGVIAVAVTQMmmyaiaIIICI---Y---AFSleetv------ 265
gi 506391958 185 IYTSQTAQEIASEKGTKIMEVIFSS-VPANHYFYGRILGIFAVILTHM------TIYVAggyL---CFKlanklemtke- 253
gi 345284523 200 TYSTTTAQEIGSEKGTKIMEVLFSS-MPAKNYFYGKMLGLTIVIVLHI------SIYAIgggV---IYAlaprlwgde-- 267
gi 584607723 198 TFLSMITTEIASEKGSRAMEMLLVS-VKPTTHFKAKIAGVLLLALTQM------GILAAv--F---LIYaklvkggivw- 264
gi 524466879 201 YYGYGVAMSISSEKTSRVMETLIIS-AKPSKILIGKCLAMGVLGLLQL------VGLMA---FaafCYKfilpegfqi-- 268
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81531262  261 ----------------ANWG--GH-----PILVlGIVSSFAILAASIGFLFMIIT-GDD-KR-A-SMLISVTAP-IFTFV 312
gi 123016183 259 -------emvknildgISLD--NLigpflWYSL-LFMIFGILIFSVLAALCGSLVnKAE-DT-A-KAILPVTYL-SLGGY 324
gi 81585289  263 ------sllsgispqsIFSS--TF-----IFTL-GFFIIGILVFAVLAALCGSLV-SKPeDT-A-KAVQPIMYI-GLIGY 324
gi 122268912 255 plladnqalingvihnLFNI--NL-----LFLF-LGVVIYTILAAYSGALVAKAE-DAS-KA-A-QPVVMLSML----A- 317
gi 506381358 263 -------kkfnvkftdVTMH--LL-----IVGV-ICFIIGIISYTILGTILGSLA-TRI-ED-MnQALMPMTAV-SFIAF 323
gi 501846551 266 ------------nelgFTFGteNVri--lVYAI-IFLILGLLIYISSSAIIGSLT-NRI-EDiG-QAIMPVTML-NMIAF 326
gi 506391958 254 ------wiqnmkplldSLIK--HLd----WSIL-FFAIFGILLYVVLAALCGSLV-VRP-EQ-A-NQAAQLPIF-LVIAA 315
gi 345284523 268 -------alfktayemINIIfkHL-----ISINlVYVLLMIILCTVLAALCGALV-VRI-ED-S-NKAVQPVMY-LIIAG 330
gi 584607723 265 -------dmaadivkeLSVG--YV-----IYAI-VFLLLTVILYLIIGALFGSLV-SKVeEA-G-QVLMPAMII-TIIGF 325
gi 524466879 269 -------agvdlavsgFTPK--TL-----VFLI-IYFILGYALYAVMNSVCGAAV-SKM-ED-L-NSAMMPVSIlVIIGF 329
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81531262  313 SGGY-VK--Vp---fSDG--SIIKYVPNNLAQSGLFNMIyKGV---TSTAeNSIIILLGMSIVLLA-IAS 370
gi 123016183 325 MLGL-ILg-Asd--pNNIviRITSYIPFLSSYIMPVRLA-NETvgmGGAL-ISLLVLVAVTFLLMI-LSA 387
gi 81585289  325 MIGI-TFg-Tnd--pQNIvvKVTSFIPLISSYIMPVRLA-TETastMEAI-VSLVILAVFGIILTI-FSA 387
gi 122268912 318 FFAA-FPf-Qnn--lDALavKILSYIPFFSSYFMPMRII-NNT---ANCG-EQLISLTILLATIGL-FAL 377
gi 506381358 324 YIAL-LN--Lnt--pETMltKIASFIPLLSPFVLFLRAS-TPE---LQLW-EIIVSVLLSLIVMILlLWI 383
gi 501846551 327 YIAM-FS--Lsk--pDTLlvKIASYIPFFTPQIMLLRTIsTKTs-dIEIM-IGIIICIITIILLLF-IAA 388
gi 506391958 316 FMGA-FV--LgqgnsDPLllKIGSYLPFFSTFFMPIRLI-NGF---AHLN-QSLISLLILALTTLF-ITM 376
gi 345284523 331 FIASmAF--Qgk--pESVivVALSYIPGVSAFFMPLRII-NGTvgtIGIG-VSLTLFLATVILA---Ivw 391
gi 584607723 326 YVML-TG--Mgn--pDTIiiKIFSYIPLTSGMIMPMRIG-ATDiggIVPL-LSLGILIATIIVVYL-FSL 387
gi 524466879 330 YLGY-FTsvMgg--gSGMlsKLAVYLPISSPFAVPFKLI-TGEitmKELG-ISVFLLVLAIVIVTM-FSt 393
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