Conserved Protein Domain Family
MCM2_N

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pfam12619: MCM2_N 
Mini-chromosome maintenance protein 2
This domain family is found in eukaryotes, and is typically between 138 and 153 amino acids in length. The family is found in association with pfam00493. Mini-chromosome maintenance (MCM) proteins are essential for DNA replication. These proteins use ATPase activity to perform this function.
Statistics
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PSSM-Id: 338421
View PSSM: pfam12619
Aligned: 22 rows
Threshold Bit Score: 85.5368
Threshold Setting Gi: 299751403
Created: 29-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659107   46 DEEDE-IHN-DVADLN---P-S----EEEDGEDLM-DN-MENDYKRSEKQDTYD-LgdGN-ID--DE-EYDEMdAATRRR 108
gi 729065     44 AAEAL-VEE-DIEDLDgeaL-Dv---EDEEGEDLFgEG-MERDYQQNLELDRYD-I--EE-LD--DDnDLEELdIGARRA 110
gi 74684137   65 DDEAE-VRRiGRENGDd--------dEEEEGEDLFnDD-MMADYEENAGLDTYS-Q--AD-LD--DRsSVAGPtRAERLA 128
gi 122248801  49 AEEAE-VDPnVLPEDDgvvA-Ae---EEEDGEDLFnDN-YLDDYRRMDEQDQYEsVglDDsIE--DErNLDEI-MADRRA 119
gi 19112269   42 DEAAEaLVEeDIEDLDg-eAlDv---EDEEGEDLFgEG-MERDYQQNLELDRYD-I--EE-LD--DDnDLEELdIGARRA 110
gi 213405567  44 eaeeavveeeigelDDe-lP-Dp---NEEDGEDLFgED-MEKDYVQNLELDRYD-I--DD-LD--DEnEFETMdIGERRA 111
gi 930413049  58 DEEAE-MRArGRRDAG---D-Ed---TDDEGEDLFnDDnLQRDYEVNPELDRYS-D--AG-LD--DRsSVQEMsRADRLA 123
gi 299751403  49 pppfsdtdEsGIDDRDgllD-AegedEEEDGEDLF-EN-LEADYAPNELLDRYS-D--AD-ID--DDgDAAELsAAQRRA 119
gi 164663207  66 DSHSM-LDQvDDDPDDlvnG-Ae---NEDDGEDLFdDT-MMADYRANPELDTYEaV-----GL--DEaDFEHMdATTRQL 132
gi 254573042  54 dDEQE-IGEeEIPIIDeeeV-D----EEDDAEDLIgDN-MFDDYRQNRDQDHYD-------IDqiDDnEYEQMdPEERRK 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74659107  109 IDSQLNKRDALLGda-----mGNRSRRQAFLEDEG-DedniddideyglpiQRRRRRQYd----eD----ADEFMGDvei 174
gi 729065    111 VDARLRRRDIELDa------aAGRTKPAAFLQDED-Ddldsn----lgtgfTRHRHRIY------DeyspNVGALDE--- 170
gi 74684137  129 AERAMDLRDRGVSgr----raGRRDHMPAFLQSDD-Deaeafgd-dplagiNIRRRRRQy-----------DERMDEddv 191
gi 122248801 120 AEAELDARDVRTGa-------APDRKLPRMLHDQDtDedm--------sfrRPKRHRANfrpprePrtprSDDDGDGatp 184
gi 19112269  111 VDARLRRRDIELDa------aAGRTKPAAFLQDED-Ddldsn----lgtgfTRHRHRIYde--ysP----NVGALDE--- 170
gi 213405567 112 LEQKLNERDQKSGk------aSGKGKPAAFLQEDD-Edlnsd-----fgfpFKHRNRQYde--leP----TATVMDEd-- 171
gi 930413049 124 AEREMARRDRGLTgg----raARRGRVPTFLQSDD-Dddgavdg-gllsgiNTRRTRRQy-----------DERMDEddi 186
gi 299751403 120 AEAQMARRDRLERagkkgsraFIRTKAPTFLGSDDmDddgdvdd-elglsqFKARTRRHy-----------DERRDQddm 187
gi 164663207 133 AELRMARRDRAEGvgrm------srrAPVFLQSDDeSedd---------vlRQRRRRRHy-----------DEVQEEda- 185
gi 254573042 120 VDKLLNEKDRLQKqa----laADRDI---YLGDGA-Dmdveidt-rtglpvQSRRRRTAyd---dDrlghDDDDLEDid- 186
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 74659107  175 ------------------dpfNEELSLESLTDiKAPSI 194
gi 729065    171 ---------------------SGELPLESIADvKADSI 187
gi 74684137  192 ------------------eedEEEMSLEHLGDvKAASI 211
gi 122248801 185 sspgrsqrgmysggdvpmtdqTDDDPYEDEFD-EEDEM 221
gi 19112269  171 ---------------------SGELPLESIADvKADSI 187
gi 213405567 172 ----------------------GELQLEAIADvKADSI 187
gi 930413049 187 --------------------eedEMSLEHLGDvKASSI 204
gi 299751403 188 ------------------egiEDELPLEQLGDiKAKSI 207
gi 164663207 186 -------------------aeVDELPIEQLSDiKADSI 204
gi 254573042 187 -------------------plAEELTLESLADvKAESI 205
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