Conserved Protein Domain Family
TMF_DNA_bd

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pfam12329: TMF_DNA_bd 
TATA element modulatory factor 1 DNA binding
This is the middle region of a family of TATA element modulatory factor 1 proteins conserved in eukaryotes that contains at its N-terminal section a number of leucine zippers that could potentially form coiled coil structures. The whole proteins bind to the TATA element of some RNA polymerase II promoters and repress their activity. by competing with the binding of TATA binding protein. TMFs are evolutionarily conserved golgins that bind Rab6, a ubiquitous ras-like GTP-binding Golgi protein, and contribute to Golgi organisation in animal and plant cells.
Statistics
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Aligned: 47 rows
Threshold Bit Score: 29.9671
Threshold Setting Gi: 238631893
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
LoveMIT:GQ68_00642T0  271 NNLQKKLEAKELQVKELLEEGMKLSSNEVSLLQTVKRLKQENNSLA--NELNNASeinRKLESRSQKLDALEKEFIKEE 347  Komaga...
Q75DU4                129 SSLLLLVKEKDARIEELLEEQQETSAKERRATQALSKMEKKYNKQV--AESAALE---QKLRKQASENVLLKEEKDKAK 202  Eremot...
XP_015634535           71 LQLENVVREKSAQIAALVSELEVLQVPNVADDESVLKANAHNEMLE--KQVLRLG---SDLEDQVKKGESLEARASEAE 144  Japane...
Q6FK79                 97 SSVFKLIKGKDEEIAQLTKKLEDRRKQDTANEKLLSKLTADNEKLN--KNNDNLS---KKLNESNQEISNLQQKYSLSE 170  [Candi...
CAO98778               95 VSVLKLVKGKDEEIDQLKKNVEKYERQENLGKLKIGKLKEAMEIAT--SSRDQLT---KELNLVVMEKDSLVSKLKEAE 168  Nakase...
EEQ30579              282 KWMREDMESKEADIAELQ---EQLKSAESKQAEEVANLREEINELE--YTIREKD---RRIEEKEEEIENLQSKHADEN 352  Micros...
ACR50691                9 KGEAE-LNAKQAELAKKQTELEKLLDSLDPEGKTQDELDKEAAEAElnKKVESLQ---NKVADLEKEISNLEILLGGAD 83   Strept...
EAW09274              540 LDLLATITEKDDQIEELQEESQDLRDDNDKLRQTLDMLSKENGATL--EQTAVLK---QEASRLQESVEQGRLLLGQKD 613  Asperg...
EEE64668              510 SDAAALLKEKDEIISQVMAEGEELSKKQAAQEATMRKLRAQVRELE--EEKQRLN---SKIQVEETKVESIKRDKAATE 583  Japane...
EDQ56321              300 SDSSMLLKEKDEIIKAVMAEGEELSKKQAAIEGTVKKLRAQVRELE--EEKNRLS---SKLQVEEAKVESMRKDKAATE 373  Physco...
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