Conserved Protein Domain Family
HoxA13_N

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pfam12284: HoxA13_N 
Hox protein A13 N terminal
This family of proteins is found in eukaryotes. Proteins in this family are typically between 149 and 306 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of the Hox gene protein involved in formation of the digital arch of the hands and feet as well as in correct genital formation. Mutation of the protein is associated with hand-foot-genital syndrome.
Statistics
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PSSM-Id: 463521
Aligned: 20 rows
Threshold Bit Score: 73.3854
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q3V614        28 SKNMDGLvGGGNFatAASQCRNIMAhsaaaaalggHASGLMHSs-----AGFSTVDVSTSGSGETaatsGKQCAagqcaA 102 Japanese medaka
XP_005995687  31 NPGMEGL--SGNC--PATHCRDLIShpa----lgrHSSTIATHq----gPVYSDIAAPEAG---------RQC------- 82 
OCA46671      31 SPAMEGL--SGNC--ASSHCRDFIShpa----lgrHSSAIGSHq----gPVYTDITSPEAA---------RQC------- 82 
P50207        52 APSMDGL--GGSC--PASHCRDLLPhpv----larPPAPLGAPq----gAVYTDIPAPEAA---------RQCA-----P 105 house mouse
XP_004070510  31 SQTMEGL--SGNC--PATHCRDLMShpa----lgrHSGTIATHq----gSVYSDISSPDTG---------RQC------- 82 
Q3V600        31 SQTMEGL--SGNC--PATHCRDLMShpa----lgrHSGTIATHq----gSVYSDISSPDTG---------RQC------- 82  Japanese medaka
OCA23571      10 QWEMEGLrGGGEGp-SSNQCRNFLSsps----vfgSPSSRTVPg-----LAYSAPDRSGSARAEAt----KEGP-----T 70 
XP_004764951  12 AKAMEGLpGAG-------GSRNLAArsp----lpsHPAAAGAPpllpaaVSYAPLDLPGSAEPP------KQCH-----P 69 
XP_006638382  27 NKNMEGLvGAGNF--AANQCRNLMAhsa----lggHPSTLVHGs------GYSAVDVSGSGSGEP----GKQCA-----P 85 
XP_007232293  27 NKNMEGLvGSGNF--AANQCRNLMAhsa----lsaHPSSLVHGs------SYSTVEVSTSSAAET----SKQCT-----P 85 
Q3V614       103 AAAMphQSSSAAtALPYGYF-GNGYYPCRMGR-----GSLKSCT--QAAG--AALSSQYMDTTVS--PDEYPNH 164 Japanese medaka
XP_005995687  83 -PAP--QTSSSA-TLGYGYPfGGTYYGCRLSHshnvnLQQKPCS--------YHPAEKYAETSSSlpSEELSSR 144
OCA46671      83 -TAP--PSSSNA-SLGYAYPfGSSYYGCRLSQs----HNVNLHQ--KPCS--YHPAEKYPEPSNPlpSEEFSSR 144
P50207       106 PPAP--PTSSSA-TLGYGYPfGGSYYGCRLSHnv--nLQQKPCA--------YHPGDKYPEPSGAlpGDDLSSR 166 house mouse
XP_004070510  83 -PAP--QSSSSA-SLSYGYPfGNPYYGCRLSHshnvnLQQKPCS--------YHPAEKYAEPSTAlpSEELSSR 144
Q3V600        83 -PAP--QSSSSA-SLSYGYPfGNPYYGCRLSHshnvnLQQKPCS--------YHPAEKYAEPSTAlpSEELSSR 144 Japanese medaka
OCA23571      71 CPAS--TGPSGP-SLGYGYHfGNGYYSCRMSHgv--gLQQNPLKssSHASlgGFPVEKYMDVSGL------AST 133
XP_004764951  70 CPGVp-QGTAPA-AVPYGYF-GGGYYSCRVSR-----SSLKPCA--QAATlaAYPAE----TAAP--GEEYPSR 127
XP_006638382  86 CPAVp-QGTSTApPLPYGYF-GNGYYSCRMGR-----GSLKSCT--QPGAlsSYSAEKYMDTPVP--SEEYPSR 148
XP_007232293  86 CPTVp-QASSTG-PIPYGYF-GNSYYPCRMGR-----GSLKSCT--QPSAl-SYTAEKYMDTPVT--SEEYPSR 146
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