1ZR9,4DGW


Conserved Protein Domain Family
zf-C2H2_jaz

?
pfam12171: zf-C2H2_jaz 
Click on image for an interactive view with Cn3D
Zinc-finger double-stranded RNA-binding
This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.
Statistics
?
PSSM-Id: 338268
View PSSM: pfam12171
Aligned: 123 rows
Threshold Bit Score: 29.4397
Threshold Setting Gi: 122051569
Created: 29-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
1ZR9_A        51 HRCLACARYFIDSTNLKTHFRSKDHK 76  human
Q16QC5       316 FFCDICDRSFNRVDYLKEHFKSKRHR 341 yellow fever mosquito
Q16M83        54 LTCILCNSVVRSEAVWKVHINSKQHK 79  yellow fever mosquito
Q7S2D3        30 LVCVLCREHIKTEALWDGHIRNTAHR 55  Neurospora crassa
Q6P0I6        48 LMCALCDAPVKNALLWQTHVLGKQHK 73  zebrafish
Q292H8       201 LICLYCEKVFKDRTTLKEHMRKKGHK 226 Drosophila pseudoobscura
XP_001319904 280 WFCDYCGRIVDNANVFKTHCATKKHK 305 Trichomonas vaginalis G3
CAF98476      46 lSCVLCNVQVKSELLWPTHVLGKPHK 71  spotted green pufferfish
XP_005165646 264 PFCTLCERHFRTPRKFVEHMKSSEHK 289 zebrafish
XP_012981878 629 PFCTICNRYFKTPRKFVEHVKSQGHK 654 golden hamster
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap