1ZR9,6G90


Conserved Protein Domain Family
zf-C2H2_jaz

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pfam12171: zf-C2H2_jaz 
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Zinc-finger double-stranded RNA-binding
This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.
Statistics
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PSSM-Id: 371938
View PSSM: pfam12171
Aligned: 121 rows
Threshold Bit Score: 29.4424
Threshold Setting Gi: 75337315
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1ZR9_A    51 HRCLACARYFIDSTNLKTHFRSKDHK 76  human
Q17L08   395 YYCKTCNCIMADEKLFSQHWYGKKHK 420 yellow fever mosquito
Q9W0R2   307 YYCQPCNMMMNHESTLQQHFIGKKHl 332 fruit fly
Q16M83    54 LTCILCNSVVRSEAVWKVHINSKQHK 79  yellow fever mosquito
Q6P0I6    48 LMCALCDAPVKNALLWQTHVLGKQHK 73  zebrafish
Q7S2D3    30 LVCVLCREHIKTEALWDGHIRNTAHR 55  Neurospora crassa
Q292H8   201 LICLYCEKVFKDRTTLKEHMRKKGHK 226 Drosophila pseudoobscura
EDL08543 605 PFCTICNRYFKTPRKFVEHVKSQGHK 630 house mouse
EDO80818  28 LRCTLCDLAFKDSLTLVQHLSSEAHR 53  Giardia lamblia ATCC 50803
CAF98476  46 lSCVLCNVQVKSELLWPTHVLGKPHK 71  spotted green pufferfish
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