1ZR9,4DGW


Conserved Protein Domain Family
zf-C2H2_jaz

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pfam12171: zf-C2H2_jaz 
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Zinc-finger double-stranded RNA-binding
This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.
Statistics
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PSSM-Id: 338268
View PSSM: pfam12171
Aligned: 123 rows
Threshold Bit Score: 29.4397
Threshold Setting Gi: 122051569
Created: 29-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20
                 ....*....|....*....|....*.
1ZR9_A        51 HRCLACARYFIDSTNLKTHFRSKDHK 76
gi 122093706 316 FFCDICDRSFNRVDYLKEHFKSKRHR 341
gi 122116755  54 LTCILCNSVVRSEAVWKVHINSKQHK 79
gi 74615075   30 LVCVLCREHIKTEALWDGHIRNTAHR 55
gi 82186117   48 LMCALCDAPVKNALLWQTHVLGKQHK 73
gi 121989026 201 LICLYCEKVFKDRTTLKEHMRKKGHK 226
gi 123473432 280 WFCDYCGRIVDNANVFKTHCATKKHK 305
gi 47220377   46 lSCVLCNVQVKSELLWPTHVLGKPHK 71
gi 528480914 264 PFCTLCERHFRTPRKFVEHMKSSEHK 289
gi 880971184 629 PFCTICNRYFKTPRKFVEHVKSQGHK 654
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