Conserved Protein Domain Family
Fibrinogen_aC

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pfam12160: Fibrinogen_aC 
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Fibrinogen alpha C domain
This domain family is found in eukaryotes, and is approximately 70 amino acids in length, and the family is found in association with pfam08702. This domain is the C terminal domain of fibrinogen in mammals. The domain lies in the C terminal half of the alpha C region in these proteins. The function of the domain is that of intramolecular and intermolecular interactions to form fibrin.
Statistics
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PSSM-Id: 288972
View PSSM: pfam12160
Aligned: 15 rows
Threshold Bit Score: 84.8162
Threshold Setting Gi: 1706798
Created: 22-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam12160 is a member of the superfamily cl13578.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2JOR_A          4 N-EKVTSG--H-TT-TTRRSCSKVITKTVT-NADGRTETTKEVVKSEDGSDCGDA-----DF------Dwh------hTF 60
gi 1706799    445 GkEKVTSG--S-TT-TTRRSCSKTVTKTVI-GPDGHKEVTKEVVTSEDGSDCPEAm----DL------G---------TL 500
gi 431901229  803 GnEKVISG--GgPT-ASRHSCSKTITKTVV-GADGRRVVTKEVVNSEDGSDCDITt----DS------Dsf------hTF 862
gi 558098354  367 GkEKVISG--G-LT-SSRSSCSKTITKTVI-GADGRKQVTKEVVTSEDGSDCGDAt----DL------Dsf------lT- 424
gi 395542501  378 SgEKDTSG--T-RT-TTRHACSKTITKTVV-GPDGRKEVTKEVVNSEDGADCGDIp----DFnferpeGss------fSF 442
gi 612030903  380 SgEKAKSG--A-TT-ITRRSCSKTITKTVV-GPDGNKQMTKEVINSKDGDDCS-------DF------DfehpeegsfTF 441
gi 664731106  473 GgEKVTSG--S-TT-TTRRSCSKTVTKTVI-GPDGHKEVTKEVVNSEDGSDCGDAv----EL------Dlf------rTF 531
gi 620979931  363 vgSKDTSG--L-FT-TKRSSCSKTVTKTIVnGPEGPKEVTKEVLTSDDGSDCSDLagvgfDL------Gtg------gIF 426
gi 344291671  446 tgEKVTSG--S-TT-TTSRSCSKTVTKTVI-GADGRKEVTEEVVTSKDGSDCGDPk----DL------Dlf------hSL 504
gi 3789966    215 SnERATSGssS-STsTVRRSCSKTITKTVT-GPDGHKQVVKEVVHSEDGSECPEVp----DL------Dsm------hSF 276

                  ....*....
2JOR_A         61 PSRGNLDDF 69
gi 1706799    501 SGIGTLDGF 509
gi 431901229  863 SGKGGLDEF 871
gi 558098354  425 SSRGSLDEF 433
gi 395542501  443 TGLGSLDEF 451
gi 612030903  442 TGLSSLDEF 450
gi 664731106  532 PGEGSLDGL 540
gi 620979931  427 NSRGTPDGT 435
gi 344291671  505 AGRGSLDEF 513
gi 3789966    277 MSRGSLDDF 285
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