Conserved Protein Domain Family
Telomerase_RBD

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pfam12009: Telomerase_RBD 
Telomerase ribonucleoprotein complex - RNA binding domain
Telomeres in most organisms are comprised of tandem simple sequence repeats. The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition. One major influence on telomere length is the enzyme telomerase. It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. The RNA binding domain of telomerase - TRBD - is made up of twelve alpha helices and two short beta sheets. How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA.
Statistics
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Aligned: 133 rows
Threshold Bit Score: 67.5225
Threshold Setting Gi: 429962320
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBX90294  470 HVSAFCRAVIAKAI--------PKGFWG-----GDGNKRVVMYWIDQFIHLRRFESLTLHQ-VTQKLQITTLd-wLSLsN 534  Leptosphaeria mac...
CCF56096  263 NVLKMVILVLEKLI--------PQEAYG-----SKRNKSVIFSKIPLLLSLPLNGSLPAET-IFENVRSRNLy-wLT--G 325  Kazachstania afri...
CCD27067  300 EITRFLIIILEKLI--------PSELLG-----SKRNKSKLFKMVPMILSFPGNTTIEFGRyALKNFKVKDLaisLL--- 363  Naumovozyma daire...
CDF87506  268 lVNKFVIIILQKLI--------PSEMFG-----SKRNKSKIFYYLSQLLRLPLKGTIPFSE-LKNSQRIEDFr-wIR--- 329  Zygosaccharomyces...
CCH61189  258 DVVRFIILLLEKLI--------PQKLFG-----SKKNKSIIFSNLSSFISLPIGGSISISD-VMMNIQVTKFs-wLH--- 319  Tetrapisispora bl...
EDO17339  272 DVNRFLIVILEKLL--------PKDCLG-----SSKNKSYLFSKISKLINLPMYSNMSFIE-IVEGLKTNDFk-iFT--- 333  Vanderwaltozyma p...
CCE65283  268 NVNKFLTIILEKLL--------PIELLG-----SKKNKSIIFKNASRLLRQSITSNIPFNN-IIEKISTTHFs-wLQ--- 329  Tetrapisispora ph...
EGD78625 2236 QVVRFACACVRFLV--------PKSLLG-----SKRNWRVFNRLVRDMVTLPRYASISREV-CLHAFSTSAVp-wLAP-P 2299 Salpingoeca rosetta
Q4D161    365 iMTSYLRSLLGGIWwrapqateRVSFWG-----EALVLERLCAITLSWLQCGRHENFPLSH-FLHQMPVAKLp-wLRgfy 437  Trypanosoma cruzi
CAM44169  499 VVVSYLRTLLSTLRwaprkgakEGPFWGitaagSEHVLDALMRAVQGWLIAGRHAVVPVSR-FLDGVPVAQVp-wLNGfY 576  Leishmania brazil...
CBX90294  535 GETAHKLATS-----------DFEKRKEIFFEFIYWLFDSFLIPLIRTNFHVTE-SNVHRHRLFYFRHDVWRMLSE 598  Leptosphaeria maculan...
CCF56096  326 --KQHDFSLK-----------THLRTCMMFKQFLLWLFRNLIPRIIIRFFYCTEvSS--SLNIIYFTHDQWKKLTR 386  Kazachstania africana...
CCD27067  364 --KRSTITRD-----------YFEVLTQVQHCFVLWTLTNLIPKILSTFFYCTEiSS--TTNVIYFRHDVWNELTA 424  Naumovozyma dairenens...
CDF87506  330 --LVANCNES-----------SLQNNQRLVACFISWIFKLIIPRIVTTFFYATEvSS--SVLVLFFRHDAWSKISA 390  Zygosaccharomyces bai...
CCH61189  320 --KLSSSSLN-----------DFQLLTNLVHHFVYWLFTFLISNLISIHFYATNvSS--KVEILYFRQDTWHSISK 380  Tetrapisispora blatta...
EDO17339  334 --SGKKLSLP-----------EFNKLKLIIHQFTSWIFRFLVPNIISTFFYCTNvSS--GIEIIFFRHDVWNKISM 394  Vanderwaltozyma polys...
CCE65283  330 --GTKKNNLQ-----------ENLISQLIIDSLVAWIFQFLIPRIVSSFFYCTNvSS--TIDILYFRHDIWNVLSF 390  Tetrapisispora phaffi...
EGD78625 2300 -TPAVRACPS-----------DHALQRHLLRTCVVWLLEHVVAVVLRSAFYITE-RSKDKNAVLFYRKCLWREIDR 2362 Salpingoeca rosetta
Q4D161    438 trg-------------sgrrrRSMIQQRVLLQFFFFLFQHVVPFLVRSSFHVTW-SSKKPNAFLFIPKSVWIRLVS 499  Trypanosoma cruzi
CAM44169  577 TSPSTSSSAAtssaarharheRSRVQQRVWLQFVLFLTQDILPFLVRASFTVTW-SSKNTHTLLFFSVAVWRRLVR 651  Leishmania braziliens...
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