Conserved Protein Domain Family
RNase_Zc3h12a

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pfam11977: RNase_Zc3h12a 
Zc3h12a-like Ribonuclease NYN domain
This domain is found in the Zc3h12a protein which has shown to be a ribonuclease that controls the stability of a set of inflammatory genes. It has been suggested that this domain belongs to the PIN domain superfamily. This domain has also been identified as part of the NYN domain family.
Statistics
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PSSM-Id: 314796
View PSSM: pfam11977
Aligned: 21 rows
Threshold Bit Score: 110.496
Threshold Setting Gi: 918700857
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4Y011       111 KFRSIIIDGANVCakvinnknsqyyFDNGe-----------IEIIYDCHILYEAYLFFKKIHVEDIIIVLNPVmk----- 174  Plasmodium cha...
Q9TYQ2        36 LLRPVFMNAVEVGy----------sYAHCd-----------RDKKLNVRGVTIALWHFICRGHQAIALLPYCF------- 87   Caenorhabditis...
Q4JSB5        60 ERRTVLLDACNVS------------HYQN------------RLPRFSVERLAKALEYFVENGHEVYAVFPRFHl------ 109  African malari...
Q5TX22       399 MKRMVIIDGNNVA------------YGHL------------NGKMFSVKGLELCINYFKKLGF-EVTAVVPQF------- 446  Anopheles gamb...
Q17KS7       330 KKRFVVIDGNNVA------------FAHT------------HGQAFSVKGLDICIQYFKKLGH-EVKAVVPQF------- 377  yellow fever m...
Q23342        69 VARTIVIDGANVM--------------HCgsgypdrrenskSSHIPDVMPLLSLIRFFVVRDFEVFVVISRKYa------ 128  Caenorhabditis...
O26281        15 GYLRVIIDASNVA--------------HSrk---------nDEEKPCIENILSAAEELEKLGYEPVIIADASL------- 64   Methanothermob...
XP_002639356 249 nLRSVVVDGSNIA------------MLHG------------RKEVFSCAGLRECLHYFLERGHPEVLIFIPQY------- 297  Caenorhabditis...
XP_002633081  67 VRRTIVIDGANVM--------------HCgsphtdhrkgaiQQNIPDVAALFSLIRYFVVRDFDVLTVISRKYa------ 126  Caenorhabditis...
XP_001008737 813 SKQLIIIDGMNVA------------IRYG-------------QSTFCAKGLQIVVD-FWLNHQAEVLVFLPDFcfsadqi 866  Tetrahymena th...
Q4Y011       175 qGNEYylRTKKVFNYTYLEKLIKLNVILISNEKYYHSNkgevvKRRTYDDVLILELALHKKGCVISNDNYADiWMRTs-N 253  Plasmodium cha...
Q9TYQ2        88 -KNYA----EKSSRYSELMMLYRLNLIEFTPGYGSEKY-----TEV---NRIMVNRAYETGGCLVARSQMQG-ITDN--K 151  Caenorhabditis...
Q4JSB5       110 -------YTGQWDNVDRLQGLYRKSYIVPTPCKEFPCA-----KSQVYDDRILMAIAAQYQCAVVSNDRFRD-VASE--H 174  African malari...
Q5TX22       447 -KLKR----YQSTDQALLEQMHRNGDVTLAPCKSLPGQ-----CSSSYDDRLILSIAEQFDGVIISNDNFRD-LLDI--S 513  Anopheles gamb...
Q17KS7       378 -RLKK----EKSTDQRLLEELYKKGDILLAPSKNLPGQ-----KSSSYDDRLIISVAEKFDGVIISNDNFRD-LMEE--N 444  yellow fever m...
Q23342       129 -------KQDATNFKSAIDRLIENHLCVVVPSSNLD-------------DSVALQFASQINGVVITTDQYRD-HASD--S 185  Caenorhabditis...
O26281        65 --------RHEIDDKEQFRKLLEEGKFQQVPSGTSA-------------DHFILKMAEEEDAKILSNDVFRD-YKDE--- 119  Methanothermob...
XP_002639356 298 -RREQprSDSPITDQHILLEIERH--IIYTPSRNVNGR-----RVVCHDDRYILRTAELKDAVIVSNDEYRD-LTRE--N 366  Caenorhabditis...
XP_002633081 127 -------KPGATTFKRAIDELVENNLCIVIPSSYL-------------DDTVALEFAAQLNGVVLTSDLYRD-HSNM--N 183  Caenorhabditis...
XP_001008737 867 eKKRQkfQKEKIPEKFKTLPDEVETLIKLRDQGYATGI-----PNQSYDDSYMIDYARKKNAFIMTNDRYND-HIQNykN 940  Tetrahymena th...
Q4Y011       254 rKEIQDIISY----YVIKHSYDKNRGF--SLDLTKKPLKYILN 290  Plasmodium chabaudi
Q9TYQ2       152 -SHLIDVVEQ----RLLMPTFNGDDIMfpIDGPLGRNGPSLEQ 189  Caenorhabditis elegans
Q4JSB5       175 -PDWAFVAAN----RRLPFDW----------DSNGRLAIYNTD 202  African malaria mosquito
Q5TX22       514 -PEWRRIIET----RVVGYSWVKDCFFl-PDDPYGRYGPTLQQ 550  Anopheles gambiae str. PEST
Q17KS7       445 -DSWKKIIET----RVAGYTWVMDAFFl-PDDPYGRKGPSLTD 481  yellow fever mosquito
Q23342       186 -LRFNTIVRE----NRLGIKWENVKCK-------NTRAPNIEN 216  Caenorhabditis elegans
O26281       120 ---FQDINS-----RRIPYTFREDKILigTSGKPKKVKNILQK 154  Methanothermobacter thermautotrophicus str. Delta H
XP_002639356 367 -PAWKKIVEE----RLLMFTFVEDKFMp-PDDPSGRNGPRIEs 403  Caenorhabditis briggsae
XP_002633081 184 -NRSRRVVEK----HRLNIGWEIi-----NDESRNMRLKNpem 216  Caenorhabditis briggsae
XP_001008737 941 dPKQMEIVKQwirnNCMSFTFVKDELQpdPDFIQKRTKISLEK 983  Tetrahymena thermophila SB210
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