Conserved Protein Domain Family
Rad60-SLD

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pfam11976: Rad60-SLD 
Ubiquitin-2 like Rad60 SUMO-like
The small ubiquitin-related modifier SUMO-1 is a Ub/Ubl family member, and although SUMO-1 shares structural similarity to Ub, SUMO's cellular functions remain distinct insomuch as SUMO modification alters protein function through changes in activity, cellular localization, or by protecting substrates from ubiquitination. Rad60 family members contain functionally enigmatic, integral SUMO-like domains (SLDs). Despite their divergence from SUMO, each Rad60 SLD interacts with a subset of SUMO pathway enzymes: SLD2 specifically binds the SUMO E2 conjugating enzyme (Ubc9)), whereas SLD1 binds the SUMO E1 (Fub2, also called Uba2) activating and E3 (Pli1, also called Siz1 and Siz2) specificity enzymes. Structural analysis of Structure 2uyz reveals a mechanistic basis for the near-synonymous roles of Rad60 and SUMO in survival of genotoxic stress and suggest unprecedented DNA-damage-response functions for SLDs in regulating SUMOylation. The Rad60 branch of this family is also known as RENi (Rad60-Esc2-Nip45), and biologically it should be two distinct families SUMO and RENi (Rad60-Esc2-Nip45).
Statistics
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Aligned: 33 rows
Threshold Bit Score: 59.0997
Threshold Setting Gi: 124445740
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q59WH5              410 FVIGLKGKDNK-RVEVKVSPETQLRKLLSYYLRHKGLSEDtvdlSKAKLIFDDEEMDLNDTVGDTELEEDYEIQVVI 485 Candida alb...
Q55FZ7              484 ITVTLIDSETLkKIHFSIARHSPLKKLINCFIEKKSTVHP----NNINFTFKGKPISPQNTCCDLSINDGDFIDAII 556 Dictyosteli...
A7WLI0               18 INLKVAGQDGS-VAQFKIRRHTPLSKLMKAYCERQGLSI-----RQIRFRVDGQPINETHTPAQLELEDEDTIDVLQ 88  pig
CAM37138             36 ISLKVVNADGA-EMFFKIKRGTQLKKLIDAYCKKQGISR-----GSVRFLFDGAPIDESKTPEDLGMEDDDVIDAMV 106 Leishmania ...
A0D2P6               10 LNLKVKSQDGE-EVFFKIKKQTQFKKLMDAYCSRQNLQI-----QNVRFLFDGERILETQTPADIGMETGDEIDVVI 80  Paramecium ...
CAW65573             21 INLKVKGQDGN-EVFFRIKRSTQLKKLMNAYCDRQSVDF-----NSIAFLFDGRRLRAEQTPDELEMEDGDEIDAML 91  soybean
CAW65556             17 LNIKVKDADGN-EVFFKVKRTTKLSKLKKAYAERMGKPE-----NSVRFIFDGQRIGDNDTAETLGMEDQDEIDAMI 87  Ustilago ma...
WGS:AACS:CC1G_04810  22 INVKVVSASGE-EVFFKIKRSTKLSKLQGAYASKVGKDV-----NSIRFLYDGSRIQEDDTPASLDMEDNDTIDVMV 92  Coprinopsis...
Q4UIN2               19 IQLKVRSPDGS-EVYFKIKKKTKLEKLMNTYCSRLGQSP-----EAVRFLFDGDRIKGDATPEELGIENGDIIDAMV 89  Theileria a...
XP_001613230         22 IQVKVRSPDGA-EVFFKIKRKTKLEKLMEVYCNRLGQSM-----EAVRFLYDGDRIHGENTPDQLGIEDGDVIDAMV 92  malaria par...
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