4F5C


Conserved Protein Domain Family
ERAP1_C

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pfam11838: ERAP1_C 
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ERAP1-like C-terminal domain
This large domain is composed of 16 alpha helices organized as 8 HEAT-like repeats. This domain forms a concave face that faces towards the active site of the peptidase.
Statistics
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PSSM-Id: 338125
View PSSM: pfam11838
Aligned: 778 rows
Threshold Bit Score: 50.7184
Threshold Setting Gi: 524592886
Created: 29-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4F5C_A       598 WVlLNVNVTGYFQVNY-DEdNWRMIQHqLQ--TnlSvIP----VINRAQVIYDSFN-LATAHMVPVTLALDNTL-FLngE 668
gi 124448363 529 YVlLNFDDGSFVKTSY-SQqQADFFLKn----L--SnLS----TINRVLVLRSIWD-QVRDGLTGFTTFINGVLkSLlnE 596
gi 124456831 613 ALlLNYEDQSFVKVLL-DQeSTKYFSQnLQavQ--D-------ILTRTLIYRALFD-SVRDGKISSEEYVDFLLaQLprE 681
gi 121986829 628 AVlLNYADQGYIKINF-DDvSFNFFKKnVCkiN--D-------ILTRTLIWGVFYD-LVRDGKISSEEFVEIFIeNIpnE 696
gi 896423978 546 LLmLNAEDHTYAKVALtDEdGLQAAIE-GV--S--TlES----ALSRGLIWGSLWE-NVRDARLPVTTYVDAVVrNVskE 615
gi 296931790 530 VVlPNDDALSYLKVAF-DArSLEAA---LV--Y--DvED----ALSRSVVSGQLWQ-MTYDGLLKPEQYAAFVg-----r 591
gi 501358769 544 YVfINAEDHDFAIWSW-TSvNKDNL-------E--FvLEfdndPMRKLILWTDYFRqVS-LANLSFDEFKETAIrLYpmE 612
gi 118381659 574 AVlLNYGDWGFIKVLL-DDiSIEFFKLnLHkiT--D-------IVTRTLIWRAFFD-MVRDGKLSSEEYIDIFInAIpnE 642
gi 471221835 572 AVlLNYQDFAFIKVLL-DDlSIVFFKNnMHkiK--D-------VLTRNLIWRAFFD-MVRDGKLSSEEYFDIFMtAIphE 640
gi 829188310 565 AVlLNYGDYAFIKTIL-DPvSLTFLQHnLHkiS--D-------VLTRTLIWKAFYD-MARDGKISSEQYVDIFIsCIknE 633
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4F5C_A       669 KEYMP--WQAALSSLSY-FSLMFd------R-SEvy----gPMKKY-LRKQVEPLFQHFetltkNWtEr-------pENL 726
gi 124448363 597 TDDAV--LQMVLEWCTGgV--SF-------Y-CPi-----kHRQTF-ENELAHVIIELLr----K--Cp----------k 642
gi 124456831 682 NSDEI--LNTQLLYLQS-AIASM---------TPr------KFKKilGKRVFTFLLEQI-----IK-Vsk---------d 728
gi 121986829 697 QSEDI--ITNQVENITQ-LYSQY---------TPe------KYKLalGERIFNFLLMYL-----LS-Ipk---------- 742
gi 896423978 616 PSASL--LGTMVNNAQV-AIATF-------S-AP----------TG-RERLYDALYD-------AF-AaalaqakpgSDE 665
gi 296931790 592 EPLLP--SASLLSQRTT--SALYaf----rHfSPvds-rseVLNGY-FDMALASREQ-------A--Ep----------d 642
gi 501358769 613 TDTKIkrW--LLSRLTSdTGSSYftsrfwfP-ESkrnnhldSLQNF-ILSELTKAKA-------G--S------------ 667
gi 118381659 643 TSDDI--ITSQLQYLQG-AYSSF---------TPe------QYKLvlGERVFNFLLKYL-----LS-Ipa---------- 688
gi 471221835 641 QSDDI--ITNQLMFLNS-AYSQF---------TPr------KYQNqlAARMFNFLVSYL-----LK-Ipk---------- 686
gi 829188310 634 VSEEI--VAPQFTYLSN-IVSLF---------TPl------KYKSilKQKLFSFCYNFL-----LS-Tsk---------- 679
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4F5C_A       727 MDQYSE-INAISTAC-SNG--LPq---CENLAK--TLFDQW---MSDpen----npIHPNLRSTIYCNA--IAQ-G---- 783
gi 124448363 643 ENKNKR-LILLDYLA-LWGtsQQnlefLLQHINsdDAEFGF---------------IGLSNGWRIIRNI--FANlNi--p 701
gi 124456831 729 PQQENK-LILLRNNM-AAF--AYd---NTCVDE---L-LAW---FQGqnqelssieCTKDTKWAIVKLV--YAS-Qkyds 791
gi 121986829 743 -dNKNR-IICVRDSL-DSF--ARs---EVHIIK---L-VNW---LKKedqdlkhieIGLALSWRIVALA--HKC-Kk--y 802
gi 896423978 666 QLILLRaLISVSTNA-TKG--EEl---CRDIAR--GAFEDTtgdIadat----gipYDQNLGWSALGAL---ASr----- 725
gi 296931790 643 TDPHTIwTRAIALIGsLLSe-------RDADVA--RILEET---------------TDSDLRWMLLIAR---SAsGa--v 693
gi 501358769 668 DEQKYLfLSLIDSS--FTEs-------SQKRLY--EILENKlsfP-Gl-------kLDQDLRWNMIVKLssLAI------ 722
gi 118381659 689 -eNKNR-IIAVRDKL-DGF--ARs---DAHIAK---L-LAW---YNGtdedlknieVGLSVQWRIVSLV--HKS-Rk--y 748
gi 471221835 687 -eNKNR-IIEIKDKL-DFF--ARn---NEHIVY---L-LDW---YNGnnqdlkdfeLGNSIEWRIVSLV--HKS-Kk--f 746
gi 829188310 680 -eQKNK-IITIKTAL-IQY--ADs---QEQISS---L-VQW---FKGqnkelegfeIGNEGEWQIVCLA--HQS-Sq--y 739
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4F5C_A       784 GQDQ----WDFAWGQ---L-QQAQ-L-VNEADKLRSALA-CSNEVWLLNR-YLGYT-Ln-PDLIr---KQDATST---IN 843
gi 124448363 702 KEQK----WQLF-EK---WaQRDG----TDEVRLQKRF---LENLFNFDK-LWDYF-------InynkEESIPMVreaMA 758
gi 124456831 792 NPELrkeiLEKMLQI------DTS-D--AASRAQLKCKA-LIANEQERAA-LWQKYvDpnD-KEs---AKMIAES---MA 853
gi 121986829 803 TREEknalFQKQKER------DPS-D--TSQYNQHLCKA-LDLSPDERET-LWKFYiSssN-KLs---VKNLTYS---WS 864
gi 896423978 726 DLVT----VEDL-DRaakY--SPSsIsSNGYAYAIAALPsAERKAAAYKTiMEDESl-----S-----NDALAST---IN 785
gi 296931790 694 TREE----LDAELAR------TGA-A--SDVVSHLEATA-SLPG---GRAeTLNTL-L--TGALs---NDHLQAL---VN 747
gi 501358769 723 DRNK----IQTMIDRekkL--DPS-N--RGVNSSLAAEA-AEPNPKIKDK--WIQIlLn-PKASd--ySSSTLRV---VS 784
gi 118381659 749 TREEktqlFKKQAER------DPS-D--TSKNYEQKCKA-LDVNAEEREK-LWNFYfSaeN-TLs---VRNLEYS---WS 810
gi 471221835 747 TRDQknslFNIQSQK------DQT-D--TKYNYEYKCKA-LDANQQEREQ-LWNSYiNydG-KTs---LRRIQFS---WS 808
gi 829188310 740 TLQEkkqiFDEQLKK------DSS-D--TSKNMEQKCRA-IVASAEERQV-LWNQYiNk-L-EFs---QRILQNS---ME 800
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4F5C_A       844 -SIa-SN--VIGQPLAW-DFVQSNWKkLFQDy--G---GGSfSFSNLIQGVTR--RFSs--------eFE--LQQLEQFK 901
gi 124448363 759 -AF---N--HKIYLEQLqTYEQKYFEaLPTi--fSt-kSSE-YAKEFYHSLYP--INDni-------nSY--IELCEKTL 817
gi 124456831 854 -GFnnER-----RYLSLePYQDKFFEvIIQi--fQt-kSND-FSKTFYDYLFP--ITDdl-------aSL--CNKVEKLR 912
gi 121986829 865 -GFnsTF-----NRTDLmPYFDKFFGvIKTi--iDt-kSQE-FASEFFSYLLP--VTEdf-------qRL--IQNLEQLL 923
gi 896423978 786 -GFarG---PVELRES---YYDSYFEaLLPLwasR---SIG-MATRIVRGLYPkaPYNtgsteglgveGNpsVALAQRWL 854
gi 296931790 748 -GF---TqyQHAAEAR--EALPHFFElIEEm--wRt-rSQE-LAERLIYGLYPm-SDLaegtl-peenAD--VVEATRWL 813
gi 501358769 785 ySLfpEH--QKGIQLQ---FLDTYFAaLDKf---QhtdDEN-YLDAFAKSLAP--DFCt--------dET--LLILKKF- 842
gi 118381659 811 -GFnsSF-----NHEELePYFEKFFEkILHv--yDt-kPKE-FANDFYQYLLP--NTEdy-------aKL--ISRLESLL 869
gi 471221835 809 -GFsqTF-----NPDELePYYQKFFDsVIVi--hSk-qNKE-YANDFYQYLFP--VSEdw-------dRL--IKSLNQLK 867
gi 829188310 801 -GFvsTK-----DSDLIkPYNEKFFAdIKVv--yAn-qIPE-YASIVYDSLQP--QSDdl-------dWL--IAQYTNVL 859
                        410       420
                 ....*....|....*....|....*....
4F5C_A       902 --KNN--M-DVGFgsgTRALEQALEKTKA 925
gi 124448363 818 --LKS--Q-HDIL---TKFLKDSIDADQR 838
gi 124456831 913 ttVPE--N-LITL---KMQVDKSLDSLKR 935
gi 121986829 924 snLDE--D-HSYF---KVLIEEQLDDIQR 946
gi 896423978 855 --EANpeA-PSAL---RRLVLEAQDHGHR 877
gi 296931790 814 deTPD--A-PAAL---RKIILDQRDTHLR 836
gi 501358769 843 --TNNhpKlPASV---KKTLWKQIDSEKR 866
gi 118381659 870 snLNE--K-YVFL---QRYIKESIDDCQR 892
gi 471221835 868 sgLSD--K-YVHL---HRHINESIDDINR 890
gi 829188310 860 ssVPS--T-QVFF---TRRLKETLDLLQR 882
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