3K1L


Conserved Protein Domain Family
FANCL_C

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pfam11793: FANCL_C 
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FANCL C-terminal domain
This domain is found at the C-terminus of the Fancl protein in humans which is the putative E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2.
Statistics
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PSSM-Id: 314629
View PSSM: pfam11793
Aligned: 10 rows
Threshold Bit Score: 110.6
Threshold Setting Gi: 30698155
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3K1L_A       307 EELRCNICFAYRLd--------GGEVPLVSCDNAKCVLKCHAVCLEEWFKTLMDGKTFLEVSFGQCPFCKAKLSTSFA 376 fruit fly
Q3MUH5       301 FTKDCGICYAYRL---------NGTTPDQVCNEPRCGQPFHQACLYEWLQGLPSSRQSFNVIFGECPYCNKPLTVKSS 369 chicken
Q29B73       302 QEKHCNICFVYRLd--------SGEVPIVSCDNPRCVLQCHAACLEEWFKTLLDGKTFLDVSFGLCPYCKAKLSTSFA 371 Drosophila pseudo...
Q9CR14       303 FSMDCGICYARHL---------NGAIPDQVCNNPQCGQPFHEICLYEWLRGLSTSRQSFNVFFGDCPYCSKPITLKMS 371 house mouse
Q7PSZ3       146 GEDSCGICMNYQDg--------YDRVPVISCDNEQCNLIFHIHCLKEWFATQRESKKIFTISIGNCPYCTHKISSSFD 215 Anopheles gambiae...
Q17FW9       295 DAIQCGICMSYRDd--------QNKIPIISCDNEKCSLIFHIGCLKEWFMSLKDSRTFFAISVGTCPYCKQKVSSSFD 364 yellow fever mosq...
NP_080199    303 FSMDCGICYARHL---------NGAIPDQVCNNPQCGQPFHEICLYEWLRGLSTSRQSFNVFFGDCPYCSKPITLKMS 371 house mouse
XP_001315697 268 TEIECPICFCERF---------GGELPEIVCENPKCAKHYHRSCLVDWLRENRKMEQSFHCIYGTCPNCGAKIQVDDS 336 Trichomonas vagin...
OCA33405     295 fSMDCGICYAYRL---------DSAIPDQVCDDPRCGQPFHQACLYEWLRGLPSSRQSFNIIYGECPYCNKPITLKMS 363 western clawed frog
NP_201375    137 QQVECGICYAQFLptdeelgarSGTRTDYTCENISCNKSFHSLCLTDWLRSITTTRQSFDVLFGNCPYCSDPVAVKTS 214 thale cress
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