3K1L


Conserved Protein Domain Family
FANCL_C

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pfam11793: FANCL_C 
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FANCL C-terminal domain
This domain is found at the C-terminus of the Fancl protein in humans which is the putative E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2.
Statistics
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PSSM-Id: 314629
View PSSM: pfam11793
Aligned: 10 rows
Threshold Bit Score: 110.6
Threshold Setting Gi: 30698155
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
3K1L_A        307 EELRCNICFAYRLd--------GGEVPLVSCDNAKCVLKCHAVCLEEWFKTLMDGKTFLEVSFGQCPFCKAKLSTSFA 376
gi 123901030  301 FTKDCGICYAYRL---------NGTTPDQVCNEPRCGQPFHQACLYEWLQGLPSSRQSFNVIFGECPYCNKPLTVKSS 369
gi 121991924  302 QEKHCNICFVYRLd--------SGEVPIVSCDNPRCVLQCHAACLEEWFKTLLDGKTFLDVSFGLCPYCKAKLSTSFA 371
gi 44888848   303 FSMDCGICYARHL---------NGAIPDQVCNNPQCGQPFHEICLYEWLRGLSTSRQSFNVFFGDCPYCSKPITLKMS 371
gi 74800294   146 GEDSCGICMNYQDg--------YDRVPVISCDNEQCNLIFHIHCLKEWFATQRESKKIFTISIGNCPYCTHKISSSFD 215
gi 122106685  295 DAIQCGICMSYRDd--------QNKIPIISCDNEKCSLIFHIGCLKEWFMSLKDSRTFFAISVGTCPYCKQKVSSSFD 364
gi 13385416   303 FSMDCGICYARHL---------NGAIPDQVCNNPQCGQPFHEICLYEWLRGLSTSRQSFNVFFGDCPYCSKPITLKMS 371
gi 123455915  268 TEIECPICFCERF---------GGELPEIVCENPKCAKHYHRSCLVDWLRENRKMEQSFHCIYGTCPNCGAKIQVDDS 336
gi 1043420775 295 fSMDCGICYAYRL---------DSAIPDQVCDDPRCGQPFHQACLYEWLRGLPSSRQSFNIIYGECPYCNKPITLKMS 363
gi 30698155   137 QQVECGICYAQFLptdeelgarSGTRTDYTCENISCNKSFHSLCLTDWLRSITTTRQSFDVLFGNCPYCSDPVAVKTS 214
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