Conserved Protein Domain Family
RSS_P20

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pfam11757: RSS_P20 
Suppressor of RNA silencing P21-like
This is a large family of putative suppressors of RNA silencing proteins, P20-P25, from ssRNA positive-strand viruses such as Closterovirus, Potyvirus and Cucumovirus families. RNA silencing is one of the major mechanisms of defense against viruses, and, in response, some viruses have evolved or acquired functions for suppression of RNA silencing. These counter-defencive viral proteins with RNA silencing suppressor (RSS) activity were originally discovered in the members of plant virus genera Potyvirus and Cucumovirus. Each of the conserved blocks of amino acids found in P21-like proteins corresponds to a computer-predicted alpha-helix, with the most C-terminal element being 42 residues long. This suggests conservation of the predominantly alpha-helical secondary structure in the P21-like proteins.
Statistics
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PSSM-Id: 152193
View PSSM: pfam11757
Aligned: 3 rows
Threshold Bit Score: 196.995
Threshold Setting Gi: 75550531
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6X987     10 KVGAVVERlcdpsvtlTEVMDE-INDFNSFLALVHSMKSDMNGDHQDGHHEmGEHKSRLLCNIEAKLRILLDIIRRRFTR 88  Citrus tristeza virus
Q0GK46     23 VVGAVERR--------TDGLKQhCLEFNNSLAIKAALKCDANSDVMSRKNS-AKEKLEILTEIDANCAILLKLLRKKVVR 93  Strawberry chlorot...
YP_874193  25 RRTDVTHS--------GDTLNPlIRALNDSIGTLTAMKLDANTTKLCGYYSeASNKLKHCATVEELIREWLFGCRRILIT 96  Raspberry leaf mot...
Q6X987     89 DKLLCTSATDVMGFFVMRYMSS-SHTSFESVMRTELKLVVKAVLSDLSRAHKLDFSERAFAAY---GIL 153 Citrus tristeza virus
Q0GK46     94 YELGVRSMQGTFDYIYQKYSSLhPEVPHSEILRHKITPAAQEVIEALSEEYKLSLSDRSFPGFlvlGVS 162 Strawberry chlorotic fleck-as...
YP_874193  97 DVLGIRSIHDTFHFMINKFSEL-TNVPLSEVYEMKMKHVSTLVIREMIREHRLDISETCFPGH---GIL 161 Raspberry leaf mottle virus
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