4FHM,5A9Q


Conserved Protein Domain Family
Nup160

?
pfam11715: Nup160 
Click on image for an interactive view with Cn3D
Nucleoporin Nup120/160
Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 sub-complex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 sub-complex, but rather that it regulates the association of the sub-complex with the NPC and other proteins.
Statistics
?
PSSM-Id: 314558
View PSSM: pfam11715
Aligned: 21 rows
Threshold Bit Score: 211.537
Threshold Setting Gi: 145354226
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FHM_B         27 LWVPAL-ENDSEDDSEAIEta------ddNEKLFKKECVAYDAGVYTsn-ksKGSQTLRWSi--FQNRTLT--I--FDVS 92
gi 121994998   23 VTIHTGdTLNSLQDSQNF-------------EISGGHSYKNNNVMYR-------NRFIYWR---TNKSVLE--L--GEVS 75
gi 13124656    28 VKINTG-TQSTLQDLKTFE------------TSGGYCYKNTKNVQTR-------NRFIYWR---TYQDVLE--L--SEVS 80
gi 121957196   27 INVSTG-GIHNMLQDVKT-----------SEQCGGYCFAEREDFRSN--------RFIYWR---TCRDSIF--L--SEVS 79
gi 597501031   28 ISVPSP-SVSSSSIGANSSednecvqlplSEDYASSSVIGEPSISFV------------WRinkTSPNALE--L--LQLS 90
gi 74634742    25 VEIDGS-KLITKKVVDERKrkle---sddAEEVFLRRYVSKEGQMFQs----STNGEFSVRf-fDESHIMEvtG--VNHD 93
gi 74587734    22 VKLPLN-YPTIDNHNPKKSt--------tPNNEFHKKIATTGKIINLpk--qSIVPAVSISv-yNDMKTIVltP--MEFQ 87
gi 74961591    43 LVYGSE-ISFTDGFAIKPArtfvv-ntnaPLHSNGFDVQPSAGVATFphcsnYGDRIFLWR---AIGQKLF--I--EERS 113
gi 347972395   24 LSISSG-GYNAMLMDSKT-----------PEIAGGFRLNHIVNGVTL------LNRFIYWR---TCRETIL--F--SEIC 78
gi 150951579   22 ITLPLK-YPSQNQEQNT-------------NERFHALLAETGAIIDLsa-sqSYIDFVSWDl-lADLKTIT--LspINSS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FHM_B         93 -LNskkEPLSKFNVKIHFP-SNV---MKDGVAFSFSEHsD---TTIIYAITHARVLYYIRLS-KTWFQ---------L-- 152
gi 121994998   76 -LD---ISLVRNQLRMRFN-EST----VLNVSLTEQPQ-A---ITLLVVTVSSVHRYVFPLKtATVEVgaaagpddlQ-- 140
gi 13124656    81 -LD---ISLQRNHLRLRFT-DSA----VLNVSLTEQGTs----VTLLVVTVSSVHRYVFPLK-VAGQEggaaspedlL-- 144
gi 121957196   80 -MN---LNLTKNNLKIGFD-ESPi--LSVDISGNQMQ------VFILIVTVTSVHRIVLRHPkVSSVNpd------gT-- 138
gi 597501031   91 -AK---SGFPITGLRFVFA-QTL---SPFAFVYADEGGdSgrlVYFLYSLTPSGVVYVLKLSnTLAYK------------ 150
gi 74634742    94 -RK---------SVRIYFP-EGL---QNHCTCVTEKDG-----VLYIDSISNSFLLYSVKLP-FALFN---------E-- 142
gi 74587734    88 -SSs--IGFQFQNLIIDLP-HSTi--STNCITFYYHQD-----HILIDLIDQNYLFITLKIAiDRFILg--------G-- 146
gi 74961591   114 -LL---YSITDGSLCIDFT-RTP---IIPGTSITIFEEgV---LCIVVPTASAIHRFYARLH-SKGHDt-------fS-- 172
gi 347972395   79 -LD---RNDIYFEMKITFEgSPV---LAIQCCKTSNSP-----LIMIIVTTAFVHRISVEMP-ASMd---------hQkr 136
gi 150951579   84 vKK---LELPLQNIQVTLP-HKIvssKSVSITYQSDQSgNedgYIIVDLVDENFLFVTLRFA-LSDfiv-----annS-- 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FHM_B        153 --PDARLDD--DWCLCYRPISF-LNQKPDLM---------A-----------AISTSeICVSFFNGGLTKIILnpkdASH 207
gi 121994998  141 --SQSIFYDvtEK--IDEPSAYfLTDGLGMPtvaa-sfmsK-----------HAQVAhFAVAYPNKLLHHVMNcvdgATV 204
gi 13124656   145 --SQSIFYDvnDK--INDPSTYyVTDGFGTMpnaavsyltQ-----------DSQSAyFAVAYQSKLLLHVMKcstgHTI 209
gi 121957196  139 --PESILANisREQICDASSFYvISNDIANAaayr--veyD-----------TGDSEaFFAVSTVSALFLFQMg---HHG 200
gi 597501031  151 ---SGSVFPldHLIHLDVRPYLnESRVTS-----------V-----------AASPGfIFLGRSDGCV------------ 193
gi 74634742   143 --DNTEHYDtsRFFQQQEDYGI-RSRKPLLLk-------sL-----------KGQSNeLVLSLCDGGLMKLERqeknGLF 201
gi 74587734   147 --QQLTLDNfeEWGYISVPYSFeLRSSPFLL---------K-----------CLDNLnLIVSLKDGGLLHFKRdeelGEI 204
gi 74961591   173 --ILARIKEddDFRRFRTSHSLsTPGRPIRAsv------tH-----------HPSRNtISYCTAEGQLVIVTL----GSY 229
gi 347972395  137 flHDSIISHlnENNMLDPLNCYnFTNDIGQv---------VpvaatvtntsnNMQCQiAIACTNSLHLLALRI------E 201
gi 150951579  152 --SKFSLGNfdQWGHISVPYSFeMRSDPYLv---------K-----------TVDPLkVIVSLKDGGFLIFKR----SAI 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FHM_B        208 YEQH----IDDSSYLFSLKKYLS--LQAFKADYRSPNtIISMIFLS----------TYNVLVMLSLDYKLKVLDLSTNQC 271
gi 121994998  205 TQEV----KEPHLMPRFLYKFAG-----ALRRAESVD--AANDMSFse------idGKTYLLVVYRSNELRLWSLDTMQA 267
gi 13124656   210 THEI----KEPKLMPWFLSNLKG--------ALTGRSeTLEAATSMafs----eigGEIFILVLYRNNELRLWSVDNLQT 273
gi 121957196  201 GVKM----TELKHNQLISRFFSN--LTDGWRRKNANApDQIVSLMFdq------lnGQSVLYAFYRNNVARIWSTSGSCV 268
gi 597501031  194 --SC----FQPIVYFQKSSGFHQelRDDTGFGRLGTVvAAVQDLFIse------vhGRNYLCVLHADGALRVWDILTYSR 261
gi 74634742   202 LTSL----FSDPSYLTSLKDRFF------SKDKIASMpHLSIHAIIsm------tnFENHLLTVSVNQTLKKWDLNTLTG 265
gi 74587734   205 NVFN----FQEQGTLIPFLGFFG-----SGKQKDVVLdGVSSNSIVdal----qigGSGVVITLSVNKVLKLWNLDGHQN 271
gi 74961591   230 TESS----DKHEEFTMGEVGLLGklLGGTDKRVSDACvMKNLRPTSgvtrerkisvQSDIVFAVTRDGWVQAWNVETKKQ 305
gi 347972395  202 GDKIeancSELDHNPLTISKLIHs-IADSWRGKSDSSqVVTLSFDQgm------seNQTFLYTLHRNGTLRVW-LLSGRC 273
gi 150951579  206 LEDVevgtFSEASSILPFTFLSGifKKDP--RQEVVLeGISSNTIVdvi-----qiDSNTIASLTVRKVLKLWSTDNLVP 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FHM_B        272 VET-IELSq------------TILPLQSFPYLTSDHTTNSFIALY---------------------------Y---PDNS 308
gi 121994998  268 VST-INCC---------------SGGGVGAPTAQGPQTNVIRKIDdrnf--------------------cvfL---SHDE 308
gi 13124656   274 VAS-INCS-------------TELGQDSAAQ---GPQNSQLRKISdqnf--------------------clfL---SHNS 313
gi 121957196  269 GAE-CFLK-------------NYDQKQEGSQTNMVRKSDNLIGVFl-------------------------aY-----SD 304
gi 597501031  262 VLC-QSIAak----------nLEGVMCVRLWLGKADYDSGIIPLAv-------------------------lY---RKSM 302
gi 74634742   266 TEIkFDSD----------------------KSKLDTEPVTRVCASgeff--------------------itfC------- 296
gi 74587734   272 LSS-LTIA-----------------SDDNTWLPTIPSKYLKSYDQedgkt-----------------iitlfIntkSGDS 316
gi 74961591   306 LPStIDLNnyfasdgkslnrdLESADFEEEKSPMEPTETVYSIRAysfdvdillivgcdlavsgksvgmrvhI---LKVS 382
gi 347972395  274 LAS-EYLS-------------KYTQSSETEF------HTSILRCSqsll--------------------alyF---SFQT 310
gi 150951579  279 TSTpIELT-------------EI--NDSSSWLTSVPAKYFQVISSktgqs-----------------ylslyY---STNS 323
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FHM_B        309 HGS------FSIYK--LNANAH---SFKLNVVIEKGiippslp-------ddefipwMLsdF--QLISSegsq---skfL 365
gi 121994998  309 GAE------FVCVQ--IDKNMTdvgSRDIELIVKHTvva---------------pdmDLidF--NVTLT----------H 353
gi 13124656   314 RAE------FICVS--IMPDADda--sVINLVQNMvpa----------------pqtDLvdF--DATSS----------H 355
gi 121957196  305 CSE------FIILRp-TSDD-----SGNVSFVKETAila---------------pnyDLidF--KLSNQ----------S 345
gi 597501031  303 NDS------MDVIT-----------VYGLHFSSAEGialsldsgl----qnipleegELrdV--RFTSD----------K 349
gi 74634742   297 GET------IYFWD-----------QNFVQVFSskipd---------------iglwSLkdM--AFRQNeg------qfE 336
gi 74587734   317 SKSmf---vFKSFE--LESSN----LHDLSDLSFQpel--------------------pnsL--LFSSDvfyhesnfqnT 365
gi 74961591   383 NDQ------IQHLQ--MFETSMsvdERLVDLELIQNyfpskese-----sldetqdgEL--Y--NPLTAal-------fS 438
gi 347972395  311 FSE------FIVIRpeVSYDSStgaISSVVLKTQCTilap---------------nndLidF--KLSDEr---------- 357
gi 150951579  324 ADNsksryvFKTWK--IRKSDTiveLELLDHLTFQpelpnilllsssaqpsfqntlwFIqdYqtQLSDDsi------kfH 395
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FHM_B        366 LI------------------IAWKSNLNTv--------IQKCNLSLDQDEs-----fSCVWSHS---LDSFSLIEKTFFD 411
gi 121994998  354 IW------------------ALWSNVEGD---------FNASTIHYGSNQ-------AIQWVSS----VLEPPPDRYCLT 395
gi 13124656   356 IW------------------ALWSNAEGD---------FHVSAAYFASNN-------AIKWVSA----ALEPPPDRYCLT 397
gi 121957196  346 IW------------------ALWCNAEGE---------MQVLTYSLSSEI-------DSFWLPI----PLESMDDKYTAK 387
gi 597501031  350 IW------------------TLKANELTSymlcqksstMEAQSYTLQEDYi-----sEQLFLSSrssSHDLLLTTHSLFS 406
gi 74634742   337 VS------------------TVWMSGVSHv--------VKKATVNRNG---------DIQWSEC---GTPLRMLPPLTVH 378
gi 74587734   366 IWfiqdyevvgfgtsqlkyyILWKSNTSSi--------LVEYTINPVNG--------AILSIEI---SHPNGFEIDENIS 426
gi 74961591   439 LS------------------ALFKSSSAKk-------tYSMKRISFAIQWkkgrvftDFDWHSVr-qFTSPATTKEEPIG 492
gi 347972395  358 LW------------------TLWCNAEGEt-------qALFYELNVEGNEn-----iHNVWSPV----ILENISDKEHQP 403
gi 150951579  396 I--------------------LWKSNTSSv--------LVTLAINFQTGAi-----eSKKW------SHSQEGKTFEELG 436
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FHM_B        412 VPTNMSSGdis----------eiWLQHIFAHNT-SIESIQVALLSFQNSSSqvsknkldKFGALTISELKNAVLSSIVST 480
gi 121994998  396 TEQGIDPRe-------------aYCSYIFHPGRfDRTVITKALYMFRRVNLq------fDVRQLSMTVLKEQVCQAVEDE 456
gi 13124656   398 MEQGVDPRe-------------tYCSYIFHPGRfDRNVIAKALYMFRRVNLq------fDVKQLSMSVLKEQVCQAVEDE 458
gi 121957196  388 LEKGTDLKh-------------vYCSRIFHSGRfHNNVIAKTLSMFNRSFTy-------SGATISTAALKRHVCSYIDGE 447
gi 597501031  407 SAKDQIMGfis----------siFLRRLLCPGIfHNVALRLTLLDHNKNWTd------sEFQSLSLDELTSEILLLVEHE 470
gi 74634742   379 DYERAVS-------------------------LySVPLLKAALSIFSRHG---------GGGNTISEAISSQLRLYTN-- 422
gi 74587734   427 AYHDAEY----------------YMDRIFDSGNyDSLIVLTSIKILSQHWEi------dNDMVVTSQSIRQLAIDTINSK 484
gi 74961591   493 NTDEVEPAierpynlsadssietLIDVVFDTDIyPFDIVFRAVQIVSDNFRgt----lgQVRNNNWPELSKLVDTYLTSV 568
gi 347972395  404 LEAGINLKd-------------vYCNRIFQSGIfSDTVIRKSLLMFNRNIAsvt--tnsSGMYSSMLRLKRYAITCMENQ 468
gi 150951579  437 PYHDSEY----------------YRNKILNSGRyNDLILQTSLDVFR------------SYKGLDSVDKKSFIRDSTEET 488
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4FHM_B        481 Iq-----iEPNSD---LTGYDYYEYKRLLYNEWERFAKLVAYLDHFGDEILSINFDPSNA---VTY------INYANKVA 543
gi 121994998  457 I-------QNEFK---EFVVSDEEYLEIATRLWDRFYSCCEQYHIKYSEPIGLSILGGMD---AAC------LIRRQSFA 517
gi 13124656   459 I-------QNELK---DFVVTDEEYLEISTRLWDRFYSCCEQYHIKLSEPTGLAVLGGMD---AVC------LVRRQSFA 519
gi 121957196  448 L-------QNERK---LQNITDEEFIDLSSNLWEKFYMCCSQYNFEACQPIGMLILDRMD---AFC------LIRKKFIS 508
gi 597501031  471 V---------------TAETSISVFHW-----WKNFCTSYLHHWCSNNEPRTLLV--QSD---VIG------LVRNNSVS 519
gi 74634742   423 ----------------HSGPDYTGYAKDQVEAWSKFEGICQELSRQASACIGSSLSGA-----QIY------ILTGTGVS 475
gi 74587734   485 A----------------------ESGTIKNY-WFKLQSLCEEFKNLSQETLSLSV--FDN---QVL------TLNVNGHG 530
gi 74961591   569 EfnrkfqqKTDRSirlRLNAPQESQKTALKDFWWALLRACEELDFAARGAISLAPIQFCGdlrIMA------VVHRDRMT 642
gi 347972395  469 Lqlecv------slrqNGPLDEDQIQEISNGLWEKFYLYCMQYRFESSRPIGLFICEKEQ---KNTsffnagIIREKYVS 539
gi 150951579  489 Ik---------------LASNNDPYETKQN--WYKLETLCAEFKKLGEEDLAISLTNQA----TLL------TIQANGLG 541
                         730
                  ....*....|...
4FHM_B        544 FI--RDPYLIESF 554
gi 121994998  518 LL--RPCELWEHI 528
gi 13124656   520 LL--RPCEVLEHL 530
gi 121957196  509 SL--RPCDELEVA 519
gi 597501031  520 LF--FRLENAEHS 530
gi 74634742   476 TI--RPSTELEKL 486
gi 74587734   531 IF--RKSAFFESF 541
gi 74961591   643 FLgdNNTEFLEII 655
gi 347972395  540 FF--RICDGVEVA 550
gi 150951579  542 IF--RPSHYFESF 552
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap