4FHM,5A9Q


Conserved Protein Domain Family
Nup160

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pfam11715: Nup160 
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Nucleoporin Nup120/160
Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 sub-complex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 sub-complex, but rather that it regulates the association of the sub-complex with the NPC and other proteins.
Statistics
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PSSM-Id: 314558
View PSSM: pfam11715
Aligned: 21 rows
Threshold Bit Score: 211.537
Threshold Setting Gi: 145354226
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4FHM_B         27 LWVPAL-ENDSEDDSEAIEta------ddNEKLFKKECVAYDAGVYTsn-ksKGSQTLRWSi--FQNRTLT--I--FDVS 92   Schizosacchar...
Q29M37         23 VTIHTGdTLNSLQDSQNF-------------EISGGHSYKNNNVMYR-------NRFIYWR---TNKSVLE--L--GEVS 75   Drosophila ps...
Q9VKJ3         28 VKINTG-TQSTLQDLKTFE------------TSGGYCYKNTKNVQTR-------NRFIYWR---TYQDVLE--L--SEVS 80   fruit fly
Q17II0         27 INVSTG-GIHNMLQDVKT-----------SEQCGGYCFAEREDFRSN--------RFIYWR---TCRDSIF--L--SEVS 79   yellow fever ...
Q9C811         28 ISVPSP-SVSSSSIGANSSednecvqlplSEDYASSSVIGEPSISFV------------WRinkTSPNALE--L--LQLS 90   thale cress
Q6C9U5         25 VEIDGS-KLITKKVVDERKrkle---sddAEEVFLRRYVSKEGQMFQs----STNGEFSVRf-fDESHIMEvtG--VNHD 93   Yarrowia lipo...
Q5AML9         22 VKLPLN-YPTIDNHNPKKSt--------tPNNEFHKKIATTGKIINLpk--qSIVPAVSISv-yNDMKTIVltP--MEFQ 87   Candida albicans
P91350         43 LVYGSE-ISFTDGFAIKPArtfvv-ntnaPLHSNGFDVQPSAGVATFphcsnYGDRIFLWR---AIGQKLF--I--EERS 113  Caenorhabditi...
XP_557517      24 LSISSG-GYNAMLMDSKT-----------PEIAGGFRLNHIVNGVTL------LNRFIYWR---TCRETIL--F--SEIC 78   Anopheles gam...
XP_001387922   22 ITLPLK-YPSQNQEQNT-------------NERFHALLAETGAIIDLsa-sqSYIDFVSWDl-lADLKTIT--LspINSS 83   Scheffersomyc...
4FHM_B         93 -LNskkEPLSKFNVKIHFP-SNV---MKDGVAFSFSEHsD---TTIIYAITHARVLYYIRLS-KTWFQ---------L-- 152  Schizosacchar...
Q29M37         76 -LD---ISLVRNQLRMRFN-EST----VLNVSLTEQPQ-A---ITLLVVTVSSVHRYVFPLKtATVEVgaaagpddlQ-- 140  Drosophila ps...
Q9VKJ3         81 -LD---ISLQRNHLRLRFT-DSA----VLNVSLTEQGTs----VTLLVVTVSSVHRYVFPLK-VAGQEggaaspedlL-- 144  fruit fly
Q17II0         80 -MN---LNLTKNNLKIGFD-ESPi--LSVDISGNQMQ------VFILIVTVTSVHRIVLRHPkVSSVNpd------gT-- 138  yellow fever ...
Q9C811         91 -AK---SGFPITGLRFVFA-QTL---SPFAFVYADEGGdSgrlVYFLYSLTPSGVVYVLKLSnTLAYK------------ 150  thale cress
Q6C9U5         94 -RK---------SVRIYFP-EGL---QNHCTCVTEKDG-----VLYIDSISNSFLLYSVKLP-FALFN---------E-- 142  Yarrowia lipo...
Q5AML9         88 -SSs--IGFQFQNLIIDLP-HSTi--STNCITFYYHQD-----HILIDLIDQNYLFITLKIAiDRFILg--------G-- 146  Candida albicans
P91350        114 -LL---YSITDGSLCIDFT-RTP---IIPGTSITIFEEgV---LCIVVPTASAIHRFYARLH-SKGHDt-------fS-- 172  Caenorhabditi...
XP_557517      79 -LD---RNDIYFEMKITFEgSPV---LAIQCCKTSNSP-----LIMIIVTTAFVHRISVEMP-ASMd---------hQkr 136  Anopheles gam...
XP_001387922   84 vKK---LELPLQNIQVTLP-HKIvssKSVSITYQSDQSgNedgYIIVDLVDENFLFVTLRFA-LSDfiv-----annS-- 151  Scheffersomyc...
4FHM_B        153 --PDARLDD--DWCLCYRPISF-LNQKPDLM---------A-----------AISTSeICVSFFNGGLTKIILnpkdASH 207  Schizosacchar...
Q29M37        141 --SQSIFYDvtEK--IDEPSAYfLTDGLGMPtvaa-sfmsK-----------HAQVAhFAVAYPNKLLHHVMNcvdgATV 204  Drosophila ps...
Q9VKJ3        145 --SQSIFYDvnDK--INDPSTYyVTDGFGTMpnaavsyltQ-----------DSQSAyFAVAYQSKLLLHVMKcstgHTI 209  fruit fly
Q17II0        139 --PESILANisREQICDASSFYvISNDIANAaayr--veyD-----------TGDSEaFFAVSTVSALFLFQMg---HHG 200  yellow fever ...
Q9C811        151 ---SGSVFPldHLIHLDVRPYLnESRVTS-----------V-----------AASPGfIFLGRSDGCV------------ 193  thale cress
Q6C9U5        143 --DNTEHYDtsRFFQQQEDYGI-RSRKPLLLk-------sL-----------KGQSNeLVLSLCDGGLMKLERqeknGLF 201  Yarrowia lipo...
Q5AML9        147 --QQLTLDNfeEWGYISVPYSFeLRSSPFLL---------K-----------CLDNLnLIVSLKDGGLLHFKRdeelGEI 204  Candida albicans
P91350        173 --ILARIKEddDFRRFRTSHSLsTPGRPIRAsv------tH-----------HPSRNtISYCTAEGQLVIVTL----GSY 229  Caenorhabditi...
XP_557517     137 flHDSIISHlnENNMLDPLNCYnFTNDIGQv---------VpvaatvtntsnNMQCQiAIACTNSLHLLALRI------E 201  Anopheles gam...
XP_001387922  152 --SKFSLGNfdQWGHISVPYSFeMRSDPYLv---------K-----------TVDPLkVIVSLKDGGFLIFKR----SAI 205  Scheffersomyc...
4FHM_B        208 YEQH----IDDSSYLFSLKKYLS--LQAFKADYRSPNtIISMIFLS----------TYNVLVMLSLDYKLKVLDLSTNQC 271  Schizosacchar...
Q29M37        205 TQEV----KEPHLMPRFLYKFAG-----ALRRAESVD--AANDMSFse------idGKTYLLVVYRSNELRLWSLDTMQA 267  Drosophila ps...
Q9VKJ3        210 THEI----KEPKLMPWFLSNLKG--------ALTGRSeTLEAATSMafs----eigGEIFILVLYRNNELRLWSVDNLQT 273  fruit fly
Q17II0        201 GVKM----TELKHNQLISRFFSN--LTDGWRRKNANApDQIVSLMFdq------lnGQSVLYAFYRNNVARIWSTSGSCV 268  yellow fever ...
Q9C811        194 --SC----FQPIVYFQKSSGFHQelRDDTGFGRLGTVvAAVQDLFIse------vhGRNYLCVLHADGALRVWDILTYSR 261  thale cress
Q6C9U5        202 LTSL----FSDPSYLTSLKDRFF------SKDKIASMpHLSIHAIIsm------tnFENHLLTVSVNQTLKKWDLNTLTG 265  Yarrowia lipo...
Q5AML9        205 NVFN----FQEQGTLIPFLGFFG-----SGKQKDVVLdGVSSNSIVdal----qigGSGVVITLSVNKVLKLWNLDGHQN 271  Candida albicans
P91350        230 TESS----DKHEEFTMGEVGLLGklLGGTDKRVSDACvMKNLRPTSgvtrerkisvQSDIVFAVTRDGWVQAWNVETKKQ 305  Caenorhabditi...
XP_557517     202 GDKIeancSELDHNPLTISKLIHs-IADSWRGKSDSSqVVTLSFDQgm------seNQTFLYTLHRNGTLRVW-LLSGRC 273  Anopheles gam...
XP_001387922  206 LEDVevgtFSEASSILPFTFLSGifKKDP--RQEVVLeGISSNTIVdvi-----qiDSNTIASLTVRKVLKLWSTDNLVP 278  Scheffersomyc...
4FHM_B        272 VET-IELSq------------TILPLQSFPYLTSDHTTNSFIALY---------------------------Y---PDNS 308  Schizosacchar...
Q29M37        268 VST-INCC---------------SGGGVGAPTAQGPQTNVIRKIDdrnf--------------------cvfL---SHDE 308  Drosophila ps...
Q9VKJ3        274 VAS-INCS-------------TELGQDSAAQ---GPQNSQLRKISdqnf--------------------clfL---SHNS 313  fruit fly
Q17II0        269 GAE-CFLK-------------NYDQKQEGSQTNMVRKSDNLIGVFl-------------------------aY-----SD 304  yellow fever ...
Q9C811        262 VLC-QSIAak----------nLEGVMCVRLWLGKADYDSGIIPLAv-------------------------lY---RKSM 302  thale cress
Q6C9U5        266 TEIkFDSD----------------------KSKLDTEPVTRVCASgeff--------------------itfC------- 296  Yarrowia lipo...
Q5AML9        272 LSS-LTIA-----------------SDDNTWLPTIPSKYLKSYDQedgkt-----------------iitlfIntkSGDS 316  Candida albicans
P91350        306 LPStIDLNnyfasdgkslnrdLESADFEEEKSPMEPTETVYSIRAysfdvdillivgcdlavsgksvgmrvhI---LKVS 382  Caenorhabditi...
XP_557517     274 LAS-EYLS-------------KYTQSSETEF------HTSILRCSqsll--------------------alyF---SFQT 310  Anopheles gam...
XP_001387922  279 TSTpIELT-------------EI--NDSSSWLTSVPAKYFQVISSktgqs-----------------ylslyY---STNS 323  Scheffersomyc...
4FHM_B        309 HGS------FSIYK--LNANAH---SFKLNVVIEKGiippslp-------ddefipwMLsdF--QLISSegsq---skfL 365  Schizosacchar...
Q29M37        309 GAE------FVCVQ--IDKNMTdvgSRDIELIVKHTvva---------------pdmDLidF--NVTLT----------H 353  Drosophila ps...
Q9VKJ3        314 RAE------FICVS--IMPDADda--sVINLVQNMvpa----------------pqtDLvdF--DATSS----------H 355  fruit fly
Q17II0        305 CSE------FIILRp-TSDD-----SGNVSFVKETAila---------------pnyDLidF--KLSNQ----------S 345  yellow fever ...
Q9C811        303 NDS------MDVIT-----------VYGLHFSSAEGialsldsgl----qnipleegELrdV--RFTSD----------K 349  thale cress
Q6C9U5        297 GET------IYFWD-----------QNFVQVFSskipd---------------iglwSLkdM--AFRQNeg------qfE 336  Yarrowia lipo...
Q5AML9        317 SKSmf---vFKSFE--LESSN----LHDLSDLSFQpel--------------------pnsL--LFSSDvfyhesnfqnT 365  Candida albicans
P91350        383 NDQ------IQHLQ--MFETSMsvdERLVDLELIQNyfpskese-----sldetqdgEL--Y--NPLTAal-------fS 438  Caenorhabditi...
XP_557517     311 FSE------FIVIRpeVSYDSStgaISSVVLKTQCTilap---------------nndLidF--KLSDEr---------- 357  Anopheles gam...
XP_001387922  324 ADNsksryvFKTWK--IRKSDTiveLELLDHLTFQpelpnilllsssaqpsfqntlwFIqdYqtQLSDDsi------kfH 395  Scheffersomyc...
4FHM_B        366 LI------------------IAWKSNLNTv--------IQKCNLSLDQDEs-----fSCVWSHS---LDSFSLIEKTFFD 411  Schizosacchar...
Q29M37        354 IW------------------ALWSNVEGD---------FNASTIHYGSNQ-------AIQWVSS----VLEPPPDRYCLT 395  Drosophila ps...
Q9VKJ3        356 IW------------------ALWSNAEGD---------FHVSAAYFASNN-------AIKWVSA----ALEPPPDRYCLT 397  fruit fly
Q17II0        346 IW------------------ALWCNAEGE---------MQVLTYSLSSEI-------DSFWLPI----PLESMDDKYTAK 387  yellow fever ...
Q9C811        350 IW------------------TLKANELTSymlcqksstMEAQSYTLQEDYi-----sEQLFLSSrssSHDLLLTTHSLFS 406  thale cress
Q6C9U5        337 VS------------------TVWMSGVSHv--------VKKATVNRNG---------DIQWSEC---GTPLRMLPPLTVH 378  Yarrowia lipo...
Q5AML9        366 IWfiqdyevvgfgtsqlkyyILWKSNTSSi--------LVEYTINPVNG--------AILSIEI---SHPNGFEIDENIS 426  Candida albicans
P91350        439 LS------------------ALFKSSSAKk-------tYSMKRISFAIQWkkgrvftDFDWHSVr-qFTSPATTKEEPIG 492  Caenorhabditi...
XP_557517     358 LW------------------TLWCNAEGEt-------qALFYELNVEGNEn-----iHNVWSPV----ILENISDKEHQP 403  Anopheles gam...
XP_001387922  396 I--------------------LWKSNTSSv--------LVTLAINFQTGAi-----eSKKW------SHSQEGKTFEELG 436  Scheffersomyc...
4FHM_B        412 VPTNMSSGdis----------eiWLQHIFAHNT-SIESIQVALLSFQNSSSqvsknkldKFGALTISELKNAVLSSIVST 480  Schizosacchar...
Q29M37        396 TEQGIDPRe-------------aYCSYIFHPGRfDRTVITKALYMFRRVNLq------fDVRQLSMTVLKEQVCQAVEDE 456  Drosophila ps...
Q9VKJ3        398 MEQGVDPRe-------------tYCSYIFHPGRfDRNVIAKALYMFRRVNLq------fDVKQLSMSVLKEQVCQAVEDE 458  fruit fly
Q17II0        388 LEKGTDLKh-------------vYCSRIFHSGRfHNNVIAKTLSMFNRSFTy-------SGATISTAALKRHVCSYIDGE 447  yellow fever ...
Q9C811        407 SAKDQIMGfis----------siFLRRLLCPGIfHNVALRLTLLDHNKNWTd------sEFQSLSLDELTSEILLLVEHE 470  thale cress
Q6C9U5        379 DYERAVS-------------------------LySVPLLKAALSIFSRHG---------GGGNTISEAISSQLRLYTN-- 422  Yarrowia lipo...
Q5AML9        427 AYHDAEY----------------YMDRIFDSGNyDSLIVLTSIKILSQHWEi------dNDMVVTSQSIRQLAIDTINSK 484  Candida albicans
P91350        493 NTDEVEPAierpynlsadssietLIDVVFDTDIyPFDIVFRAVQIVSDNFRgt----lgQVRNNNWPELSKLVDTYLTSV 568  Caenorhabditi...
XP_557517     404 LEAGINLKd-------------vYCNRIFQSGIfSDTVIRKSLLMFNRNIAsvt--tnsSGMYSSMLRLKRYAITCMENQ 468  Anopheles gam...
XP_001387922  437 PYHDSEY----------------YRNKILNSGRyNDLILQTSLDVFR------------SYKGLDSVDKKSFIRDSTEET 488  Scheffersomyc...
4FHM_B        481 Iq-----iEPNSD---LTGYDYYEYKRLLYNEWERFAKLVAYLDHFGDEILSINFDPSNA---VTY------INYANKVA 543  Schizosacchar...
Q29M37        457 I-------QNEFK---EFVVSDEEYLEIATRLWDRFYSCCEQYHIKYSEPIGLSILGGMD---AAC------LIRRQSFA 517  Drosophila ps...
Q9VKJ3        459 I-------QNELK---DFVVTDEEYLEISTRLWDRFYSCCEQYHIKLSEPTGLAVLGGMD---AVC------LVRRQSFA 519  fruit fly
Q17II0        448 L-------QNERK---LQNITDEEFIDLSSNLWEKFYMCCSQYNFEACQPIGMLILDRMD---AFC------LIRKKFIS 508  yellow fever ...
Q9C811        471 V---------------TAETSISVFHW-----WKNFCTSYLHHWCSNNEPRTLLV--QSD---VIG------LVRNNSVS 519  thale cress
Q6C9U5        423 ----------------HSGPDYTGYAKDQVEAWSKFEGICQELSRQASACIGSSLSGA-----QIY------ILTGTGVS 475  Yarrowia lipo...
Q5AML9        485 A----------------------ESGTIKNY-WFKLQSLCEEFKNLSQETLSLSV--FDN---QVL------TLNVNGHG 530  Candida albicans
P91350        569 EfnrkfqqKTDRSirlRLNAPQESQKTALKDFWWALLRACEELDFAARGAISLAPIQFCGdlrIMA------VVHRDRMT 642  Caenorhabditi...
XP_557517     469 Lqlecv------slrqNGPLDEDQIQEISNGLWEKFYLYCMQYRFESSRPIGLFICEKEQ---KNTsffnagIIREKYVS 539  Anopheles gam...
XP_001387922  489 Ik---------------LASNNDPYETKQN--WYKLETLCAEFKKLGEEDLAISLTNQA----TLL------TIQANGLG 541  Scheffersomyc...
4FHM_B        544 FI--RDPYLIESF 554  Schizosaccharomyces pombe 972h-
Q29M37        518 LL--RPCELWEHI 528  Drosophila pseudoobscura
Q9VKJ3        520 LL--RPCEVLEHL 530  fruit fly
Q17II0        509 SL--RPCDELEVA 519  yellow fever mosquito
Q9C811        520 LF--FRLENAEHS 530  thale cress
Q6C9U5        476 TI--RPSTELEKL 486  Yarrowia lipolytica
Q5AML9        531 IF--RKSAFFESF 541  Candida albicans
P91350        643 FLgdNNTEFLEII 655  Caenorhabditis elegans
XP_557517     540 FF--RICDGVEVA 550  Anopheles gambiae str. PEST
XP_001387922  542 IF--RPSHYFESF 552  Scheffersomyces stipitis CBS 6054
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