Conserved Protein Domain Family
Vma12

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pfam11712: Vma12 
Endoplasmic reticulum-based factor for assembly of V-ATPase
The yeast vacuolar proton-translocating ATPase (V-ATPase) is the best characterized member of the V-ATPase family. A total of thirteen genes are required for encoding the subunits of the enzyme complex itself and an additional three for providing factors necessary for the assembly of the whole. Vma12 is one of these latter, all three of which are localized to the endoplasmic reticulum.
Statistics
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PSSM-Id: 314557
View PSSM: pfam11712
Aligned: 100 rows
Threshold Bit Score: 56.8117
Threshold Setting Gi: 629635132
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121737704   68 LLRGT--KLYIPPPPPKPTPTPE-----------------------------------------------------YLAS 92
12_pfamImport   2 LIESS--DLVLPENEMKPR-NPD-----------------------------------------------------LEAR 25
34_pfamImport   2 LLAGC--RLKLPENPICKR-NPE-----------------------------------------------------LEAR 25
63_pfamImport   2 LLEGV--DIILPEPKVTPR-NPE-----------------------------------------------------LEAR 25
26_pfamImport   2 LFNDC--DVILPIPKESPR-NPE-----------------------------------------------------LEAR 25
gi 121957961   17 LVAGSkeKI-----------TPEvsksckefykkdvvsykdlvniktklpdgipvfvffdrltlrredhtyhasveFRKK 85
gi 242025578  284 LMKGS--DVILP-KNEVVERNPD-----------------------------------------------------LLKR 307
gi 575473914   72 LIKGS--RIEFVCPKPR-EITPE-----------------------------------------------------YIKF 95
gi 568254727   99 LLADC--WIVLPERSEQDPSSVC-----------------------------------------------------SEVD 123
gi 358332087   73 LFAST--TVVLPAPKEPIR-NAD-----------------------------------------------------LDKR 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121737704   93 KARLLAAAEADAYRRMTNPtpltgpsgPSPIFAThaptpadepDADAspETLT-------PSLVLNIFLSVLITGFSVYW 165
12_pfamImport  26 CERLRAEQHNREYHKMTKNvdaglkhypedt------------------iayqikslnkqIIAVLQFVFSVAAGFTFGFF 87
34_pfamImport  26 CQRLRKEQEDREYHRMTKNvdsirkhmpeet------------------isyqmkqinrhLIAVAQFLFSVAAGFAFGFI 87
63_pfamImport  26 IKKLQAQQDARDYQAMTKGvdnfrkhipedt------------------iafqmklmnkqLIAVAQFVFSVMAGFAFGFI 87
26_pfamImport  26 IQKLKAQQNAREYQTMTKNidsmrkflpeds------------------iayqmkqinkqLIAVAQFIISVITGFVFGFI 87
gi 121957961   86 TEELRIQQEQDSYKRLIRDvdpvqkygktdhm---------------enfgvemravnrqMISVINVVITVVGSFFFGFS 150
gi 242025578  308 IEKLKKEQEEREYKAMTQNvnldkkhfPEDSVSY------------------QmnmmnrhLIAVGQLLVSVGAGFAFGFL 369
gi 575473914   96 MEKVKIKLENKEYEDIVGKmphgksrdALGSISG---------DL------VElrkvsgqMMSLLNIFISMAAVFTALYI 160
gi 568254727  124 CAQKVRKEKQVENQQMTRSsdtarkpmPGDTIDF---------PLKhln---------rhLLAVAQFACSVVAGFVFGFI 185
gi 358332087   97 VKALREKFSNQAYDKMVEGigpklalsNSMKGSE---------TNSSlcSELkcl--nkqMVMVLNFIVVVSAGFVFGYF 165
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121737704  166 ALTSFptpeqlttavaslwgggravnrpsssragtSEAVRVLLSLFAALGVGVAEVLIYAIYWHKAGEAR 235
12_pfamImport  88 GVNLMvg--------------------------plPFGFRILLGVIVALIIALAEMYFLAKKLHEYD--- 128
34_pfamImport  88 GIELLig--------------------------qlDFGFRLLLGIIIALIIALAEIYFLAKKLNEE---- 127
63_pfamImport  88 GVELIvg--------------------------nlDFGFRLLLGVICSIVIALAEIYFLAKKLSED---- 127
26_pfamImport  88 GIELMvg--------------------------nlDFGFRLLLGIICALIIALAEIYFLAVKLSET---- 127
gi 121957961  151 GITYAyph------------------------lnlDLPTRFIFGLVPATIVFFCDLYFVVKGMDMGESSE 196
gi 242025578  370 GVELIvg--------------------------nlNFGIRLLLGIACALIIAVAEFYFLAKHLNEEDKKE 413
gi 575473914  161 FAERLw----------------------------eDQGFRVLFGLFGALVVGFAEGWFYTRDWLMDEvnt 202
gi 568254727  186 GIELLvg--------------------------qlDFGFRLLLGVMIGLIVALSEIYFLAQKLNEEDDvs 229
gi 358332087  166 IPDMLssn------------------------ldiSMATRLMCGLSVSLLIFFADLYFLIKNVSEAEKih 211
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