Conserved Protein Domain Family
Vma12

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pfam11712: Vma12 
Endoplasmic reticulum-based factor for assembly of V-ATPase
The yeast vacuolar proton-translocating ATPase (V-ATPase) is the best characterized member of the V-ATPase family. A total of thirteen genes are required for encoding the subunits of the enzyme complex itself and an additional three for providing factors necessary for the assembly of the whole. Vma12 is one of these latter, all three of which are localized to the endoplasmic reticulum.
Statistics
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Aligned: 99 rows
Threshold Bit Score: 51.8257
Threshold Setting Gi: 358368713
Created: 7-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
GAA85329      69 SLLRGT--KVYVPPP---PKKPEPvstylspthpptlytnkinkpdikkSPE------YLALKARLLAAAETDAYNRMTS 137 Aspergillus kaw...
EGF83862      71 RLIKGSriEFVCPKPre-------------------------------iTPE------YIKFMEKVKIKLENKEYEDIVG 113 Batrachochytriu...
ETO30793      48 ELLHES--DFCVPTAksiKEKAGK-------------------------SKEql---qFEEHLLQLRSKQDQREYEKLTT 97  Reticulomyxa fi...
EDW24478     149 ELIESS--DLVLPEN---EMKPR--------------------------NPD------LEARCERLRAEQHNREYHKMTK 191 Drosophila pers...
EGK96271     152 ALLAGC--RLKLPEN---PICKR--------------------------NPE------LEARCQRLRKEQEDREYHRMTK 194 Anopheles gambi...
ETN63645      98 SLLADC--WIVLPER----------------------------------SEQdpssvcSEVDCAQKVRKEKQVENQQMTR 141 Anopheles darlingi
EEB20463     283 ELMKGS--DVILPKN---EVVER--------------------------NPD------LLKRIEKLKKEQEEREYKAMTQ 325 human body louse
XP_003424813  80 QLLEGV--DIILPEP---KVTPR--------------------------NPE------LEARIKKLQAQQDARDYQAMTK 122 jewel wasp
EFN73800       6 ELFNDC--DVILPIP---KESPR--------------------------NPE------LEARIQKLKAQQNAREYQTMTK 48  Florida carpent...
GAA50803      72 RLFAST--TVVLPAP---KEPIR--------------------------NAD------LDKRVKALREKFSNQAYDKMVE 114 Clonorchis sine...
GAA85329     138 SfssssffppssrtpastkpsiftsstptlealhnkhnpkndddngtDPLT--------------PGLVLNIFLSVLITG 203 Aspergillus kaw...
EGF83862     114 Kmphgksrdalgsi--------------------------------------sgdlvelrkvsgqMMSLLNIFISMAAVF 155 Batrachochytriu...
ETO30793      98 Yhadnakagtgh------------------------------------------vgkdfaeafkeSTQALHLIIVLVGSF 135 Reticulomyxa fi...
EDW24478     192 Nvdaglkhypedt-----------------------------------------iayqikslnkqIIAVLQFVFSVAAGF 230 Drosophila pers...
EGK96271     195 Nvdsirkhmpeet-----------------------------------------isyqmkqinrhLIAVAQFLFSVAAGF 233 Anopheles gambi...
ETN63645     142 Ssdtarkpmpgdt-----------------------------------------idfplkhlnrhLLAVAQFACSVVAGF 180 Anopheles darlingi
EEB20463     326 Nvnldkkhfpeds-----------------------------------------vsyqmnmmnrhLIAVGQLLVSVGAGF 364 human body louse
XP_003424813 123 Gvdnfrkhipedt-----------------------------------------iafqmklmnkqLIAVAQFVFSVMAGF 161 jewel wasp
EFN73800      49 Nidsmrkflpeds-----------------------------------------iayqmkqinkqLIAVAQFIISVITGF 87  Florida carpent...
GAA50803     115 Gigpkla----------------------------------lsnsmkGSETnsslcselkclnkqMVMVLNFIVVVSAGF 160 Clonorchis sine...
GAA85329     204 FSVYWALRSFrspemlvstvarvwrgkgtgqgvSESVKVLVSLGAAVVVGVAEVMIYAIYLRKVEVA 270 Aspergillus kawachii IFO 4308
EGF83862     156 TALYIFAERLw---------------------eDQGFRVLFGLFGALVVGFAEGWFYTRDWLMDEvn 201 Batrachochytrium dendrobatid...
ETO30793     136 FVFYYLSHHFfq--------------------hTPGMNIVCGCVGLLLGVLVDIFLLIARQEKEERS 182 Reticulomyxa filosa
EDW24478     231 TFGFFGVNLMvg-------------------plPFGFRILLGVIVALIIALAEMYFLAKKLHEYDev 278 Drosophila persimilis
EGK96271     234 AFGFIGIELLig-------------------qlDFGFRLLLGIIIALIIALAEIYFLAKKLNEEyel 281 Anopheles gambiae str. PEST
ETN63645     181 VFGFIGIELLvg-------------------qlDFGFRLLLGVMIGLIVALSEIYFLAQKLNEEddv 228 Anopheles darlingi
EEB20463     365 AFGFLGVELIvg-------------------nlNFGIRLLLGIACALIIAVAEFYFLAKHLNEEDKK 412 human body louse
XP_003424813 162 AFGFIGVELIvg-------------------nlDFGFRLLLGVICSIVIALAEIYFLAKKLSEDyed 209 jewel wasp
EFN73800      88 VFGFIGIELMvg-------------------nlDFGFRLLLGIICALIIALAEIYFLAVKLSETdtt 135 Florida carpenter ant
GAA50803     161 VFGYFIPDMLssn-----------------ldiSMATRLMCGLSVSLLIFFADLYFLIKNVSEAEKi 210 Clonorchis sinensis
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