Conserved Protein Domain Family
RNA_pol_3_Rpc31

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pfam11705: RNA_pol_3_Rpc31 
DNA-directed RNA polymerase III subunit Rpc31
RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.
Statistics
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PSSM-Id: 338070
View PSSM: pfam11705
Aligned: 90 rows
Threshold Bit Score: 33.5015
Threshold Setting Gi: 193664642
Created: 22-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123888869   6 RGRGrnqft-------fnvdALGFGr--gDsLPTTTH-T-PSPLFPPMqFQPV-PLH--TGEEVEYMLALKQELRASSKN 71
gi 121955528   4 RGRGkatgsl----tqeqlqSMGVTr--nE-MQAVSS-AaPPPLYPILqSKPV-PLE--SNADRDYKILWKEDFISYLRE 72
gi 568259938   4 RGRGkatgtl----tqeqlqSLGVTs--kE-IQTVTSaA-PPPVFPVLlSKPV-SLE--SSVDRNYKILWKEDFISYLRE 72
gi 749795580   4 RGRGkptms-------fnteQLGVNk--gElPPQVLQpP---LPYPML-DLHVsNFE--STNEINYLVELKRDFAEYMRD 68
gi 953359359  10 RGGGrggmppgvgfgygqisQTEWKeg-iNrIKAQSQ-T-NGTLYPPLdNISI-SYLtgPTDHETLVLSHAISLNITLST 85
gi 357116406  10 RGGGgrggrg----grggrgGFGSSm-----lHQAKE-HsPYENFPEI-TLPE-MTCakATNEEKALILSTLKLEEFLRN 77
gi 193664642  13 RGGGnni----------grpHISIGpdklEa-DDPLD-FkAPELFPPLrATVT-EIE--EDSEDDDLISFEKKLAKHFHN 77
gi 195017725   4 RGRGgktgsl----taeqmqALGCVg--kD-MPQVQSa--PPPTFPPVlNKPI-TLE--TTASQNYQLLWKEDFLNRMRD 71
gi 925207033   2 RGRGraals-------fnveALGIQq--gEaLPGPVL-Q-PPPSYPALeTVTA-PIY--PSLKFGETLQYKKDFLNFYTR 67
gi 242014613   6 RGRGrgrghq----msfdynQLGFGg--gEaLPAPAL-Y-PPPTFPILeHKPL-PLK--TGAETEYMVALKRDFVEYFQS 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123888869  72 LPFHiraARTKR-------------------------DVSRYSDKYQTGEPKN-NTIEWSP--Dw-----SRLPKELCIK 118
gi 121955528  73 SPYY---TTVKSsk----------------------gPVQRYSDKVINVIEND-PKRKCEGdfLw-----SIMPAELKPT 121
gi 568259938  73 SAYFt-tKKCSKl------------------------sVQRYSDKVINVIEND-PKTKHDGdfLw-----SCMPAELMPN 121
gi 749795580  69 SLNNi-tPEVMKk------------------------dIERYSDHYQ---DVL-DNSEQKPkyDw-----SRMPEELAPS 114
gi 953359359  86 GKLP-----EGEegvqlvqsgqvppwritgerkvvgiEIESYSDRFNPPASSEpSKLDPVAlrMd----qSMFPPSLWAA 156
gi 357116406  78 SCYRlelEAPKKkde--------------------dkEIERFSDRKRKTQSK------REAlaSylkltpSNFPVELLQG 131
gi 193664642  78 AASF----------------------------------ISK--EEFTSPWSYL-KSIDNH----------NYFPPSLLPK 110
gi 195017725  72 SPYYiisASQEKqk----------------------sSVKDWREKALERLKN-----KAEPefNy-----KAMPREVNTT 119
gi 925207033  68 LRVDyeeVATSG-------------------------NKRRFDSTSISATQN----KKERPqlNye---wTRFPVELRPG 115
gi 242014613  75 LRQNnncLSA----------------------------IERFSDKYQm------ISSELKEssDsqi-ywDALPAELHPN 119
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123888869 119 VrKprktItgtKqq--lKQRPKVAa-------SKEDILQKLEtle--------------keeVHSEEEede--------- 166
gi 121955528 122 FkR----T---Ksa--aNGASKGAkk-----sKVVDINAKLSele--------------qkeSFLDDTdvk--------- 164
gi 568259938 122 FkRa---Kq-------mNAASKPKrprtvediDA--TLQALEqk----------------enTAAKAE------------ 161
gi 749795580 115 LkRkatsSlkagnnqkmKTNTKRKrprvidddDDDDNKQGTEekpkqqk-------ntkqaqDNIEKE------------ 175
gi 953359359 157 YfDg--qT---Dk---lKGRPKKRr--------------KLDdl----------------dqEGDD-------------- 184
gi 357116406 132 Srr-------------vQPSSKKLrwdrdsdeQAFDVFEKLE------------------------EKy----------- 163
gi 193664642 111 ---------------------KKKssldekllTDKQWMEKLKseitnhdylslqeivsakknKIDDFLcpankkkaktdn 169
gi 195017725 120 SrK----R---Ra-----AEPRPKlv-----aKKTNIEDRLKqleqk----------elkssGDNENDevk--------- 163
gi 925207033 116 TtK----Rp--Kki--pKVKIK----------AMADIDKMLAqleqk-----------enamFNADESvvk--------- 157
gi 242014613 120 Wkk------------alKRKSRMQscte-pkkSNIDISSRLEklakl----------edkeeNESED------------- 163
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123888869 167 -------------------------gkKKkQND-------DEeeep-----eveEDYD-E-Eel-edETDY-IASYFDNG 205
gi 121955528 165 -------------------------keKAsDSE-------DEkdd------eeqEEEVaD-Eem-ddENDY-GNNYFDNG 203
gi 568259938 162 ---------------------------GAkKEKsetddenEEdlee----eivdEEMDdD--------NDY-GNNYFDNG 201
gi 749795580 176 ---------------------------IKeEEE-------EDeens----deemEEYEiDeEmd--dGTDY-VNNYFDNG 214
gi 953359359 185 ------------------------------KVE-------EEseis----eeedFDFDdD-Es---dHQDYdA-NYFDNG 218
gi 357116406 164 -----------------------------kDGE-------KKtekdgdgdeeedDEQEsA-EeeessDDDYnQNIEFDDD 206
gi 193664642 170 pttsllinesiakeldeeedidvedseEPkKKE-------DEekdeqpkdieeeFESDvD-Del-ddGTDYn-KNYFDNG 239
gi 195017725 164 -------------------------qeSDsEHE-------DEpe---------dPEAAlD-Dem-deENDY-ANDYFDNG 199
gi 925207033 158 -------------------------veKPqDED-------NEdeegm---geeeVEHDsD-Qem-deGTDY-NSNYFDNG 199
gi 242014613 164 ----------------------------MkESE-------DKdgdddndkenleTEEDdD-Eem-ddGTDY-VNNYFDNG 205

                 ..
gi 123888869 206 ED 207
gi 121955528 204 EG 205
gi 568259938 202 Ea 203
gi 749795580 215 EG 216
gi 953359359 219 EG 220
gi 357116406 207 DD 208
gi 193664642 240 EG 241
gi 195017725 200 EA 201
gi 925207033 200 ES 201
gi 242014613 206 ES 207
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