2JUO


Conserved Protein Domain Family
GABP-alpha

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pfam11620: GABP-alpha 
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GA-binding protein alpha chain
This family of proteins represents the transcription factor GABP alpha. This alpha domain is a five-stranded beta-sheet crossed by a distorted helix termed an OST domain. The surface of the GABP alpha OST domain contains two clusters of negatively-charged residues suggesting there are positively-charged partner proteins. The OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300, a direct link between GABP and transcriptional machinery has been made.
Statistics
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Aligned: 16 rows
Threshold Bit Score: 93.1225
Threshold Setting Gi: 1005970447
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2JUO_A         7 QAIDINEPIGNLKKLLEPRL-QCSLDAHEICLQDIQ-LDPDRSLFDQGVKTDGT-VQ---LSVQVISYQGMEPKLNILEI 80  house mouse
EEB15437      77 EHMDIQCPLYTLRNILQKRF-NIDLSEYTFWLQDAQmLEPHKNLVDQCVQGEGL-VQ---INVEIKIEG-DSKKINIIDV 150 human body louse
EEC09200       4 QHMDITEPLTSLKSLLEQRL-AVSLHDYAFFLQDTQeLNASKNLVDQCVQGEGL-VQ---VNVEIINKD-GVRKINIVDV 77  black-legged tick
1_pfamImport   4 QHMNITEPLNNLRSVLEQRL-GMDLSEHVFYLQDSQeLDSSKTLVDQCVQGEGM-VQ---INVEITSK--EMKKINIVDV 76 
ESO07338     174 QCMDITEPLSTLRRLLEERF-VADYSAYELWLQDSVqLDPSKNLVSQCLEGTGT-VQ---INVEFKV---GYPRINILDV 245 Helobdella robusta
XP_015792889  62 EGIELNASVKTLCQLL--KVkYEDIESYDFYLQDNK-LTFNKSIIEQCNLVEGArQQtklINIKLIVELESR-RVTILDI 137 two-spotted spi...
XP_012399822  40 QAIDINEPIGNLKKLLERRL-QCSLDAHEICLQDIQ-LDPDRSLFDQGVKTDGT-VQ---LSVQVISYQGIEPKLNILEI 113 Tasmanian devil
Q9I9E8        40 QDIDINEPIGNLKKLLEPRL-QIPLDGYDICLQDIQ-LHPDHSLFDQGVKTDGT-VQ---LSVQIVTKPG-EEKLNILEI 112 zebrafish
EEN48075      15 QAIHINEPIGALRQLLEPRV-QSSLENHNIYLQEIP-LDPGQSLFDQGVKTDGV-VQ---LSVQIVSNTGEEPRLNILEV 88  Florida lancelet
Q4H3F7        28 QNIDIKTPIKVLKDVLSRRLrKSDLSKHDIYLQDFY-LDPDLSLFEQGVKIHGS-VE---LSIQVQSSST-NPKLIIVEI 101 vase tunicate
2JUO_A        81 VKTAET 86  house mouse
EEB15437     151 LKPTDE 156 human body louse
EEC09200      78 LKPAEE 83  black-legged tick
1_pfamImport  77 LKPADE 82 
ESO07338     246 LKPVED 251 Helobdella robusta
XP_015792889 138 LKPPDN 143 two-spotted spider mite
XP_012399822 114 VKPAET 119 Tasmanian devil
Q9I9E8       113 VKPVET 118 zebrafish
EEN48075      89 VKPIQE 94  Florida lancelet
Q4H3F7       102 VKPMQD 107 vase tunicate
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