5IJ7


Conserved Protein Domain Family
EZH2_WD-Binding

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pfam11616: EZH2_WD-Binding 
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WD repeat binding protein EZH2
This family of proteins represents Enhancer of zest homolog 2, (EZH2) a 30 residue peptide which binds to a WD-repeat domain of EED by residues 39-68. EED is a component of PRC2 complex which is involved in gene expression. This interaction is required for the HMTase activity of PCR2.
Statistics
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PSSM-Id: 314486
View PSSM: pfam11616
Aligned: 12 rows
Threshold Bit Score: 53.614
Threshold Setting Gi: 847168579
Created: 23-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20
                 ....*....|....*....|....*....
5IJ7_A        39 KSMFNSNRQKIQERTEILNQEWKQRRIQP 67
gi 444713821  39 KALYVANFAKVQEKTQILNEEWKKLRVQP 67
gi 565313118  61 KNLFVSNFTKIQEKINILNDDWKKLRVQP 89
gi 556971360  54 KSLFTANRNKVKERTEVLNEDWKKLRVQP 82
gi 327275285  44 KALFASNYAKVQEKLDILNDDWKNLRVQP 72
gi 847168579  55 rmfYVENLTKAQERAHLLNEDWKKLRVQP 83
gi 658862546  61 KSLFMSNRQKIELQTNLLNTEWSKLRIQA 89
gi 410902883  57 KALFMSNRRKIEQQTNVLNAEWSALRIQS 85
gi 523704438  58 KTLFSSNREKIEQQTTVLNSEWSTLKIQS 86
gi 973187117 146 qsqFMANRSKIKEKTELLNDEWSNLRIQP 174
gi 123893589  45 KALFQSNRRKIEVGTELLNEEWSKLRIQS 73
gi 47208503   36 KSMFSTNRQKIMERTDILNQEWKTRRIQP 64
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