Conserved Protein Domain Family
Lge1

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pfam11488: Lge1 
Transcriptional regulatory protein LGE1
This family of proteins is conserved from fungi to human. In yeasts it is involved in the ubiquitination of histones H2A and H2B. This ubiquitination step is a vital one in the regulation of the transcriptional activity of RNA polymerase II. In S. cerevisiae, Rad6 and Bre1 are present in a complex, also containing Lge1, that is required for H2B ubiquitination. Bre1 is the H2B ubiquitin ligase that interacts with acidic activators, such as Gal4, and recruits Rad6 and its binding partner Lge1 to target promoters. In S. pombe the equivalent protein to Lge1 appears to be Shf1. In human, periphilin acts a transcriptional co-repressor and regulates cell cycle progression.
Statistics
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PSSM-Id: 338019
View PSSM: pfam11488
Aligned: 43 rows
Threshold Bit Score: 43.7527
Threshold Setting Gi: 74626028
Created: 28-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9UUI2        66 SPYHYRVPSNNstrasfgaASTDtnvelpKinlpdsSLSSKLQSCKSACENSSQSLLNVEQQYAQQVHFWEKIRTDIYRE 145 Schizosaccharom...
Q9CZ70       229 DHTEFIDDQVT---------NRR------K------AIVSKTKEIEQAYYQDCETFGMVVKMLVEKDASLERPIQFALRQ 287 house mouse
XP_008109321 276 GDNELFEDTQR--------VRRA------K------AIAAKTTEIEQVYKQDCETFGAVVKMLIEKDPSLEKSIQFSLRQ 335 green anole
XP_012814208 210 GISEFHDANPH--------ISRS------R------AIAAKTKEIEEVYRQDCETFGMVVKMLIDKDPTLEKQIQFALRQ 269 western clawed ...
XP_016080912 360 ESTELSEDKQN--------TERS------K------SISSKIKEIEQVYRQDCETFGMVVKMLIDKDPSLEKCVQFALRQ 419 platypus
XP_003496748 332 ERTELVDDQLT---------NRL------K------AIASKTKEIEQAYHQDCETFGMVVKMLVDKDPSLEKSIQFALRQ 390 Chinese hamster
ELW48705     108 DGIELFEDGQL--------TNRS------K------AIGLKTKEREQAYQQGCETFGMVVKILIEKDSSLEKPIQFALRQ 167 Chinese tree shrew
ELK02220     322 DGIELFEDGRL--------SSRY------K------AIAAKTKMIEQVYQQDCETFAMVVKMLVEKDPSLEKPIQFALRQ 381 black flying fox
XP_006974379 157 DGTELYEDSQL--------SSRS------K------AIASKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQ 216 prairie deer mouse
XP_015459981 253 EDPEQTAE-----------AHRA------H------VIANKALEIEKLYRQDCETFGMVVKMLVAKQPTLEKQLETALKE 309 Mexican tetra
Q9UUI2       146 GLRSda--avKSLNDFV 160 Schizosaccharomyces pombe 972h-
Q9CZ70       288 NLHElsercvEELRQFI 304 house mouse
XP_008109321 336 NLHEigerciEELKHFI 352 green anole
XP_012814208 270 NLSEigerciEELKMYI 286 western clawed frog
XP_016080912 420 NLHEigerciEELKHFI 436 platypus
XP_003496748 391 NLHEisercvKELRQFI 407 Chinese hamster
ELW48705     168 NLHEmgerciEELKHFI 184 Chinese tree shrew
ELK02220     382 NLYEmgqrcvEELKHFI 398 black flying fox
XP_006974379 217 NLHEigercvEELKHFI 233 prairie deer mouse
XP_015459981 310 NLVEikerclEDLRQFI 326 Mexican tetra
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