Conserved Protein Domain Family
LEDGF

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pfam11467: LEDGF 
Lens epithelium-derived growth factor (LEDGF)
LEDGF is a chromatin-associated protein that protects cells from stress-induced apoptosis. It is the binding partner of HIV-1 integrase in human cells. The integrase binding domain (IBD) of LEDGF is a compact right-handed bundle composed of five alpha-helices. The residues essential for the interaction with the integrase are present in the inter-helical loop regions of the bundle structure.
Statistics
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PSSM-Id: 463284
Aligned: 28 rows
Threshold Bit Score: 97.7819
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9VAA9       320 ERDFIQLSQQLRECLGLRRANVGKCLEILEQFKEVEFTKLMLLRNPECVDIMRRLRRYVGNlelwkmdlsdevefkeraQ 399 fruit fly
CAG07956     471 EEKVQKLHTDIKFALKVDNPDIERCLQALEELEAVPVTSQILQRNAEVIATLKKIRRYKAS------------------A 532
XP_028444238 478 EEMLQKLHTDIKFALKVDNPDIDRCLQALDELAAVPVTSQILHKNAEVIATLKKIRRYKAS------------------N 539
XP_005993830 577 GERLQKLHSDIKHALKVDNPDIKKCLECLEELGGLQVTSHVLQKNTDLVATLKKIRRYKAS------------------K 638
ELK19411      34 EEKLQKLHSEIKFALKVDNPDVKRCLNALEELGTLQVTSHILQKNTDVVATLKKIRRYKAN------------------K 95 
XP_005159950 256 ESTLQKLHGEIKTSLKIGNLDVRKCVHALDELSSLHVTTQHLQRHSELIATLKKICRFKSS------------------Q 317
CAG11463     292 DLKLQRLHSEIKISLKIDRADVKKCLDALDEIGTLQVTTQHLQKHSELIATLKKIRRFKAS------------------Q 353
XP_012811664 384 DARLQRIHAEIKSSLKIDHLDVNRCISALDELASLQVSMQQAQKHTDMITTLKKIRRFKAS------------------Q 445
XP_006009435 269 ESRLQKLHGEIKISLRIEKLDVNKCIEALDELASLQVTMQHLQKHSELVTTLKKIRRFKAS------------------Q 330
EEC13642      53 EKRISELDKDIKNNLGVSGKDVDAALKALDEVDKLPLTQSLLRKEQEILYTVKKCSKFTGD------------------D 114
Q9VAA9       400 TIRKVSSGIYDGFKSLFNpEPESEDNFWIDFCEKVKIYKTY 440 fruit fly
CAG07956     533 AVMEKASDVYNKLKLRFV--GKLDMAAKPKSEGKELEENEQ 571
XP_028444238 540 AVMEKASEVYNKLKLRFV--GKPDVAAKPQTEDKEPEDDEK 578
XP_005993830 639 EVMDKATQVYNHLKLQFL-GAKADLALKSSKPGESQLEKLK 678
ELK19411      96 EVMEKAAEVYTRLKSRVL-GPKIEAIQKAARTGAEKERTEA 135
XP_005159950 318 DVMDKAIMLYNKFKSMFL-MGEGESVLSQVLNKSLTEQKLF 357
CAG11463     354 DIMDKATMLYNKFKSMFL-VGEGDCVLSQVLNKSIAEQRQF 393
XP_012811664 446 VIMDKATMLYNKFKNMFL-VGEGDSVITQVLNKSLAEQKQH 485
XP_006009435 331 AIMDKATMLYNKFKNMFL-VGEGDCIITQVLNKSLAEQRQH 370
EEC13642     115 RIKKKAEYLYHKFKNILI-VTTPEPLGATDKESEKQTEQRS 154
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