Conserved Protein Domain Family
Spy1

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pfam11357: Spy1 
Cell cycle regulatory protein
Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.
Statistics
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PSSM-Id: 314328
View PSSM: pfam11357
Aligned: 35 rows
Threshold Bit Score: 138.133
Threshold Setting Gi: 620949015
Created: 23-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81889410   205 EDLEAFYRLLEDPVVQNFLAADIFFRVTDK-----------YLLSMVVEYFGRVGLPGHLYNRIHFFLALYIACDMEEDD 273
gi 940771922   88 lELRAFLRLLEHSCLQEFLARDPCFQVSDK-----------YLLAMVLVYFRRANLQLSEYTCSNLFLALYLANDMEEDL 156
gi 821493017  128 qpkpvvpHLTEDSYLQQFFATDLCFQISDK-----------YLLAMTLIYFQRAGLQLSEYTHSNLFLALFLANDMEEDR 196
gi 405958626   52 tEMRAYFRLLEDDVIQDFLQRDACQRISDK-----------YLLAMVFAYFKRAQMKTKDYSRMNFFLALYLANDMEEDE 120
gi 321464407  105 srMKDFFILLEDGRIKGFLEQDKCKIFADS-----------YLLAMVFTYFLRAGFAHEEYNYTNFCAALFLAHDIEEEN 173
gi 313225514   13 EEITNFTIFLEDEKIVKFLEADSCHRYSDK-----------YLLATTLIYASRTKRNPLSVD--DFYCLLYLANDMEEDI 79
gi 551495307   61 QEMASYLRLFDDDLIQDFLRMDCCYKMTDK-----------YLIAMTFVYFKRAHFSIAEYTRKNFFMALYLANTMEEDE 129
gi 987415843   69 QEMTAFFKLFDDDLIQDFLWMDCCCKIADK-----------YLLAMTFVYFKRAKFTINEHTRINFFIALYLANTVEEDE 137
gi 353229948   80 tEMIAFFHLLEDTTIKKFLAFDMCFKCADN-----------FSIAYVFAYFKRCNLSIQEYNRMNFFCCLYLVHDIEEDD 148
gi 444724503   64 sqYQAFLSLLEDSFFQEFLSKDPCFQISDKrrrltnslslqYLLAMVLVYFRRANLKLSEYTRSSLFLALYLANDMEEDV 143
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81889410   274 PISKRSIFQFLLGrD-TWqDLYKDFLKLQRDFFQAMDYRAWVTPEQCVEIQ---NQNPHHWVWSRVR 336
gi 940771922  157 EEAKCMIFPWALG-E-GWhNQVADFLRQRDKLWARMGFRALVSRRHCEKVM---AMEPSHWAWTRER 218
gi 821493017  197 EDPKYEILPWALG-R-GWrKLVPSFLRQRDQLWARMGYRAVVSRHCCEEVM---AKEPSHWAWTRER 258
gi 405958626  121 EDDKYEIFPWALG-N-KWkDRFPRFLRKKDLFWARISYRAVVSRRCCEEIM---DIYPDHACWKRNR 182
gi 321464407  174 YLIDKLVVEWETK-QiQNdEEYIPMHRLRYELFVRMDYRALVPRKVCEEIM---AICPEHWAWKRKR 236
gi 313225514   80 E-FKNEILPWCLG-T-EWeSQWRSFNLRKEHLWKKMGYRALVSLELLEEIIfygEFCQKSWVWKRSR 143
gi 551495307  130 EESKYEIFPWALG-K-NWrRQFPRFLKQRDELWARICYRAAVSKSCCEEVM---AIVPSHFVWQRQR 191
gi 987415843  138 EESKYEIFPWALG-K-NWrKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVM---AIAPTHYIWQRER 199
gi 353229948  149 SDHKYEIFPWALG-S-FWqQKLSSFSRQKEALWARMGYRAVVSYRCCKELM---SIFPSHPVWSRNR 210
gi 444724503  144 EDFKCEIFPWALG-E-DWsSRVRKFLHQRDKLWARMGFRAAVSRQCCEERE---RQDP--------R 197
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