Conserved Protein Domain Family
YrbL-PhoP_reg

?
pfam10707: YrbL-PhoP_reg 
PhoP regulatory network protein YrbL
This is a family of proteins that are activated by PhoP. PhoP protein controls the expression of a large number of genes that mediate adaptation to low Mg2+ environments and/or virulence in several bacterial species. YbrL is proposed to be acting in a loop activity with PhoP and PrmA analogous to the multicomponent loop in Salmonella where the PhoP-dependent PmrD protein activates the regulatory protein PmrA, and the activated PmrA then represses transcription from the PmrD promoter which harbours binding sites for both the PhoP and PmrA proteins. Expression of YrbL is induced in low Mg2+ in a PhoP-dependent fashion and repressed by Fe3+ in a PmrA-dependent manner.
Statistics
?
PSSM-Id: 313835
View PSSM: pfam10707
Aligned: 11 rows
Threshold Bit Score: 213.737
Threshold Setting Gi: 501097847
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q16BG7         8 IKLSDDHSIANGTVRIVYAFPGQPDLLIKVFHAFEe--RSSRRPLKRLAWRLFPMLKFRTILNELKCELL------ASLk 79  Roseobacter den...
Q7VT79        49 VDLLGATLLATGSERDVYQHPGNAALLIKIVNRAR---INEPGRRRPWHKKFHREDAHRVFITELIEYIS------TTVq 119 Bordetella pert...
Q2KYP8        24 IDLNDASLLAHGGDRYVFEHPNDSCLLIKVMDMQArgvYLASRPFKRWYKQFQRESAYRVYLNEFNEYVT------STT- 96  Bordetella aviu...
Q7VWB8        13 LDLSQARLLAQGGDRYVFQHPHEPALLVKVMDMEAravYLEARPFKRWYKQFQRESAYRVYLNEITEYVT------TST- 85  Bordetella pert...
Q7CPN6         2 ILLSKQTPLGAGRHRKCYTHPDNARRCIKVIYNRD-------------------HGGDKEIRRELSYYAH------LS-- 54  Salmonella ente...
WP_011960253   2 LIIENLKHLDSGTQKNIYAHPDDTDKIIKVMKPEHa-tPDGGRRGQHTLRAHRSQGIYKQFRRELLQYLQ------LCKn 74  Psychrobacter s...
WP_047460966   2 ILLSEQNPLGTGRHRKCYAHPGDAQRCIKIIYNAD-------------------RSGKKEIRRELKYYAH------LS-- 54  Citrobacter koseri
WP_011784314   2 LDLSDKLPFAQGYNRLCYEHPLDSARCLKIVRPEN---IAARTQRQSRLKQLLGTNRLNDNTQEIIAHNQrairelLAK- 77  Marinobacter
WP_012132942   4 LTLTENDLLARGNDRYVFQHPHNHQLLIKVVIPSI---P-----------------KYKSKLREVYRDVK------ECK- 56  Citrobacter koseri
WP_012147761   2 IILKDEDFVGKGNERACYIHPEDKNKAIKITYENN------------------NRKESKQTKLEVNYYKE------LEK- 56  Arcobacter butz...
WP_012147768   2 IELREELLLGDGGERLVFIHPNDSKKVIKVLQPQI-------------------KKHNFQNELEFKYYNF------LTK- 55  Arcobacter butz...
Q16BG7        80 -LGADIENMPISRMLGIVQTDRGVGVVVERIDGLDgDLAQRLNRL---C---RRGRMDE-PVLEALNVFVGRMFDLHIVA 151 Roseobacter den...
Q7VT79       120 -LRQADGNTLLARIAGLALTSAGLGLVVEKIVDAEgKAAPTLAQV---V---STQGFGP-QLREQLRAFFLALIEAHVIF 191 Bordetella pert...
Q2KYP8        97 -RPSGIWQVPLARVMGVAQTNLGLGLLVEKIRDKNgNMAPSLKDL---I---KQGLYTQ-DIARQMDQLFEDLADAHVVA 168 Bordetella aviu...
Q7VWB8        86 -SASGVWQVPLARIVGLAQTSLGLGLLAEKITDAAgNMAPTVSDL---V---KRGEFDT-ALAQRLDRFFEDLADAHIVI 157 Bordetella pert...
Q7CPN6        55 --RYLTDWSAIPRYYGTVETDCGTGYVYDMITDFNgAPSITLTEF---AaqcRYEEDVA-VLRRLLKKLKRYLLDNHIVT 128 Salmonella ente...
WP_011960253  75 nYGANRFTFPIETVYGFVPTNQGLGLVTEKVLGPN-NIPITLYDL---E---RKQLFTA-KHAEALDRFFEECCQLHVVY 146 Psychrobacter s...
WP_047460966  55 --RYLQDWSGIPRYHGTVETDCGTGYVYDVITDFDgKPSVTLTEFvaqC---RNNEDAA-VLRQLLKTLKRYIYDNRIVT 128 Citrobacter koseri
WP_011784314  78 -GREDLVWSHLPRFYGSVQTSLGEANESELIRCADgNVAPTLETL---M---QDHGLTP-ELETGIREFLDWLKQTRILT 149 Marinobacter
WP_012132942  57 -PRDETDSLFIQKIEGLVETDKGIGQVIVKEHDQQgNIARTLYDL---A---KHNELDA-EKFSKLNAFLAWFIHTDVII 128 Citrobacter koseri
WP_012147761  57 --RRMINFKHLPKYFGEVKTDKGAGFVVELIRDFDgEVSKTFEYY---L---KKDGVLK--YKKELEEYKQYFLDNCIIF 126 Arcobacter butz...
WP_012147768  56 ---KNVDFSHITKCFGYVDTNFGKGLVFERVVDFDgEDSKFLRNC---L---QENIFTKdQEKRLLDDLKKYLEDNEILF 126 Arcobacter butz...
Q16BG7       152 R-DINFSNIVYGTRGAGA--ACFLIDGYGERNL---IPFRSMSRRMNDRSLDRQFATIARKT 207 Roseobacter denitrificans OCh 114
Q7VT79       192 N-DVSARNIVVGRNATGQd-GLFLVDGFGPKQL---LPLYAWSKTLNRRRLLRKYEDMVRKL 248 Bordetella pertussis
Q2KYP8       169 H-DISAGNVVMGYNAEGRh-GLFLVDGFGVQPL---IPAYAWSRRLNRRRLLKKYRNMRAKL 225 Bordetella avium 197N
Q7VWB8       158 H-DISASNIACGRNAEGRe-GLYLIDGFGVLPL---IPTYAWSRRLNRKRIMRKYAELRARM 214 Bordetella pertussis
Q7CPN6       129 M-SLKPQNILCQRISESEv-VPVVCDNLGESTF---IPLATWSTWCCERKLERVWQRFIAQP 185 Salmonella enterica subsp. enteri...
WP_011960253 147 G-EVNIAGIMYTEQRQGRp-EFVLVDGIGEKLV---IPFRAMSKTINDKNVRKVEAKIKAKI 203 Psychrobacter sp. PRwf-1
WP_047460966 129 M-TLKPQNILCHRISESEa-IPVICDNIGESTL---IPLASWSAWFCHRKQERQWERLIAQP 185 Citrobacter koseri
WP_011784314 150 R-NLLPHNLVVTDRI-GRt-QLFLVDGLGAPTI---PQALAPLPGWSSHYIDRKIDRFRKRL 205 Marinobacter
WP_012132942 129 N-SLHCKNIVYAWDDARQeyRFKVIDGFGDKTL---FQLSKFWSVIRDKNKLKCLRRMLRDL 186 Citrobacter koseri
WP_012147761 127 NyGMMPKNILLRKNSETDf-DLVLIDGLGDVSY---FTLPNKIPYFARKRINRRWDKFIKKY 184 Arcobacter butzleri
WP_012147768 127 I-DCSSHNVFCKKVSADKy-TLIIYDGLGARRDnikLTLYMKSRFYTRYKIKKQWKLFMKNC 186 Arcobacter butzleri
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap