Conserved Protein Domain Family
YrbL-PhoP_reg

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pfam10707: YrbL-PhoP_reg 
PhoP regulatory network protein YrbL
This is a family of proteins that are activated by PhoP. PhoP protein controls the expression of a large number of genes that mediate adaptation to low Mg2+ environments and/or virulence in several bacterial species. YbrL is proposed to be acting in a loop activity with PhoP and PrmA analogous to the multicomponent loop in Salmonella where the PhoP-dependent PmrD protein activates the regulatory protein PmrA, and the activated PmrA then represses transcription from the PmrD promoter which harbours binding sites for both the PhoP and PmrA proteins. Expression of YrbL is induced in low Mg2+ in a PhoP-dependent fashion and repressed by Fe3+ in a PmrA-dependent manner.
Statistics
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Aligned: 11 rows
Threshold Bit Score: 213.738
Threshold Setting Gi: 157699892
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:PsycPRwf_0983   2 LIIENLKHLDSGTQKNIYAHPDDTDKIIKVMKPEHa-tPDGGRRGQHTLRAHRSQGIYKQFRRELLQYLQLCKn----nY 76  Psychrobac...
Q16BG7              8 IKLSDDHSIANGTVRIVYAFPGQPDLLIKVFHAFEe--RSSRRPLKRLAWRLFPMLKFRTILNELKCELLASLk-----L 80  Roseobacte...
wugsc:CKO_02085     4 LTLTENDLLARGNDRYVFQHPHNHQLLIKVVIPSI--------------------PKYKSKLREVYRDVKECK------P 57  Citrobacte...
Q7VT79             49 VDLLGATLLATGSERDVYQHPGNAALLIKIVNRAR---INEPGRRRPWHKKFHREDAHRVFITELIEYISTTVq-----L 120 Bordetella...
Q2KYP8             24 IDLNDASLLAHGGDRYVFEHPNDSCLLIKVMDMQArgvYLASRPFKRWYKQFQRESAYRVYLNEFNEYVTSTT------R 97  Bordetella...
Q7VWB8             13 LDLSQARLLAQGGDRYVFQHPHEPALLVKVMDMEAravYLEARPFKRWYKQFQRESAYRVYLNEITEYVTTST------S 86  Bordetella...
jgi:Maqu_0795       2 LDLSDKLPFAQGYNRLCYEHPLDSARCLKIVRPEN---IAARTQRQSRLKQLLGTNRLNDNTQEIIAHNQRAIrellakG 78  Marinobact...
wugsc:CKO_04610     2 ILLSEQNPLGTGRHRKCYAHPGDAQRCIKIIYNAD-------------------RSGKKEIRRELKYYAHLS-------- 54  Citrobacte...
Q7CPN6              2 ILLSKQTPLGAGRHRKCYTHPDNARRCIKVIYNRD-------------------HGGDKEIRRELSYYAHLS-------- 54  Salmonella...
USDA:Abu_1812       2 IELREELLLGDGGERLVFIHPNDSKKVIKVLQPQI-------------------KKHNFQNELEFKYYNFLT-------- 54  Arcobacter...
USDA:Abu_1805       2 IILKDEDFVGKGNERACYIHPEDKNKAIKITYENN------------------NRKESKQTKLEVNYYKELEK------- 56  Arcobacter...
jgi:PsycPRwf_0983  77 GANRFTFPIETVYGFVPTNQGLGLVTEKVLGPN-NIPITLYDLE---RKQLFTA-KHAEALDRFFEECCQLHVVYG-EVN 150 Psychrobac...
Q16BG7             81 GADIENMPISRMLGIVQTDRGVGVVVERIDGLDgDLAQRLNRLC---RRGRMDE-PVLEALNVFVGRMFDLHIVAR-DIN 155 Roseobacte...
wugsc:CKO_02085    58 RDETDSLFIQKIEGLVETDKGIGQVIVKEHDQQgNIARTLYDLA---KHNELDA-EKFSKLNAFLAWFIHTDVIIN-SLH 132 Citrobacte...
Q7VT79            121 RQADGNTLLARIAGLALTSAGLGLVVEKIVDAEgKAAPTLAQVV---STQGFGP-QLREQLRAFFLALIEAHVIFN-DVS 195 Bordetella...
Q2KYP8             98 PSGIWQVPLARVMGVAQTNLGLGLLVEKIRDKNgNMAPSLKDLI---KQGLYTQ-DIARQMDQLFEDLADAHVVAH-DIS 172 Bordetella...
Q7VWB8             87 ASGVWQVPLARIVGLAQTSLGLGLLAEKITDAAgNMAPTVSDLV---KRGEFDT-ALAQRLDRFFEDLADAHIVIH-DIS 161 Bordetella...
jgi:Maqu_0795      79 REDLVWSHLPRFYGSVQTSLGEANESELIRCADgNVAPTLETLM---QDHGLTP-ELETGIREFLDWLKQTRILTR-NLL 153 Marinobact...
wugsc:CKO_04610    55 RYLQDWSGIPRYHGTVETDCGTGYVYDVITDFDgKPSVTLTEFVaqcRNDEDAA-VLRQLLKTLKRYIYDNRIVTM-TLK 132 Citrobacte...
Q7CPN6             55 RYLTDWSAIPRYYGTVETDCGTGYVYDMITDFNgAPSITLTEFAaqcRYEEDVA-VLRRLLKKLKRYLLDNHIVTM-SLK 132 Salmonella...
USDA:Abu_1812      55 KKNVDFSHITKCFGYVDTNFGKGLVFERVVDFDgEDSKFLRNCL---QENIFTKdQEKRLLDDLKKYLEDNEILFI-DCS 130 Arcobacter...
USDA:Abu_1805      57 RRMINFKHLPKYFGEVKTDKGAGFVVELIRDFDgEVSKTFEYYL---KKDGVLK--YKKELEEYKQYFLDNCIIFNyGMM 131 Arcobacter...
jgi:PsycPRwf_0983 151 IAGIMYTEQRQGRp-EFVLVDGIGEKLV---IPFRAMSKTINDKNVRKVEAKIKAKIS 204 Psychrobacter sp. PRwf-1
Q16BG7            156 FSNIVYGTRGAGA--ACFLIDGYGERNL---IPFRSMSRRMNDRSLDRQFATIARKTG 208 Roseobacter denitrificans OCh 114
wugsc:CKO_02085   133 CKNIVYAWDDARQeyRFKVIDGFGDKTL---FQLSKFWSVIRDKNKLKCLRRMLRDLQ 187 Citrobacter koseri ATCC BAA-895
Q7VT79            196 ARNIVVGRNATGQd-GLFLVDGFGPKQL---LPLYAWSKTLNRRRLLRKYEDMVRKLa 249 Bordetella pertussis
Q2KYP8            173 AGNVVMGYNAEGRh-GLFLVDGFGVQPL---IPAYAWSRRLNRRRLLKKYRNMRAKLP 226 Bordetella avium 197N
Q7VWB8            162 ASNIACGRNAEGRe-GLYLIDGFGVLPL---IPTYAWSRRLNRKRIMRKYAELRARMp 215 Bordetella pertussis
jgi:Maqu_0795     154 PHNLVVTDRIGRT--QLFLVDGLGAPTI---PQALAPLPGWSSHYIDRKIDRFRKRLA 206 Marinobacter hydrocarbonoclastic...
wugsc:CKO_04610   133 PQNILCHRISESEa-IPVICDNIGESTL---IPLASWSAWFCHRKQERQWERLIAQPG 186 Citrobacter koseri ATCC BAA-895
Q7CPN6            133 PQNILCQRISESEv-VPVVCDNLGESTF---IPLATWSTWCCERKLERVWQRFIAQPa 186 Salmonella enterica subsp. enter...
USDA:Abu_1812     131 SHNVFCKKVSADKy-TLIIYDGLGARRDnikLTLYMKSRFYTRYKIKKQWKLFMKNCE 187 Arcobacter butzleri RM4018
USDA:Abu_1805     132 PKNILLRKNSETDf-DLVLIDGLGDVSY---FTLPNKIPYFARKRINRRWDKFIKKYL 185 Arcobacter butzleri RM4018
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