Conserved Protein Domain Family
Misat_Tub_SegII

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pfam10644: Misat_Tub_SegII 
Misato Segment II tubulin-like domain
The misato protein contains three distinct, conserved domains, segments I, II and III. Segments I and III are common to Tubulins pfam00091, but segment II aligns with myosin heavy chain sequences from D. melanogaster (PIR C35815), rabbit (SP P04460), and human (PIR S12458). Segment II of misato is a major contributor to its greater length compared with the various tubulins. The most significant sequence similarities to this 54-amino acid region are from a motif found in the heavy chains of myosins from different organisms. A comparison of segment II with the vertebrate myosin heavy chains reveals that it is homologous to a myosin peptide in the hinge region linking the S2 and LMM domains. Segment II also contains heptad repeats which are characteristic of the myosin tail alpha-helical coiled-coils. This myosin-like homology may be due only to the fact that both myosin and Misato carry coiled-coils, which appear similar but are not necessarily homologous (Wood V, personal communication).
Statistics
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PSSM-Id: 313791
View PSSM: pfam10644
Aligned: 46 rows
Threshold Bit Score: 106.572
Threshold Setting Gi: 74590322
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q16X91         5 REILTLQLGNYANYVGTHWWNIQEASFNYDPNADp-SE--VDHDVLYREGRT--L-TRQTTYTPRLLLVDLKGTLKFMPE 78  yellow fever mo...
Q9P6K5         2 HEILTVTFGRKSNFCWTHFWNTQESYFVYDPNDH--AK--VNVNTNFRVLKK--RdPEAIVTVPRECIYDTPIEFGNTRK 75  Schizosaccharom...
Q018N1         3 SSVVTASFGTHAASVAAHFWNVRED--DSDENDEvdWN--VDHAERARVNEG----STSISYVPRWVAFDARSLRGKTTA 74  Ostreococcus tauri
Q5A2W2         2 SEIITLSYGSICNNTVTHLYNTQESLISYTPSSKp------NHDLQVFL--TrfK-STSVSYSPRALIYDLRNGLGALNK 72  Candida albican...
XP_002471242   2 KEVIYIQAGHFANYIGTHFWNTQESYFTYEEGEE--SE--VDHDVSFREGLS--L-KGDQTYCPRLLVFDRKVNFGTLSA 74  Postia placenta...
XP_004993792   7 gEVITLQFGNYANHVGAHFWNLQDAMIDYTGQEPe-SEdpISHDVLFRCGET--P-SGAPTYTPRLLLYDLRDSTSALSQ 82  Salpingoeca ros...
XP_001886252   2 KEILYIQAGQLSNYTGTHFWNTQESYFTYGDGEEp--L--TNNDVSFREGIG--P-TGELTICPRLVIFDRKANFGTLAA 74  Laccaria bicolo...
XP_001758033   2 REVVTVQLGGFANFVGAHFWNFQDEVLGSLEDGGq-IG--LDMDVLYRVGET--R-QGIATYMPRLLALDLRGNLGAVRA 75  Physcomitrella ...
XP_002173475   2 HEILSFAFGGKSNFVSTHFWNAQEKYL--DQGND--AQ--IDREVAFFERKTnnI-GGDVVFHPRTLIYDDRDAFGTTIK 74  Schizosaccharom...
EGA73548       2 HEVVTISVSQRANHLTTQFFNIQEGYLQLSKEQQ------VNDSKIFLNSVVdkV-SKTISYAPRALLWDARTGNGSLGT 74  Saccharomyces c...
Q16X91        79 EGELYQQ-RtidEE-E-----LVAG---------------------I------GWDs---------gKVEVI-K-KDPVG 113 yellow fever mo...
Q9P6K5        76 -NWLEEl----nES-S-----GGKG---------------------T------AWDg----------KLTQI-M-QTPVD 105 Schizosaccharom...
Q018N1        75 TGLSSG------DA-A-----AAAA---------------------A------AWSg----------AWTVT-R-APPTR 103 Ostreococcus tauri
Q5A2W2        73 YEYHETLpVdlnFS-L-----LSTN---------------------T------TAPagaetgagsslESGYN-LkKSRVE 118 Candida albican...
XP_002471242  75 ASDLYGE-D---EE-E-----SAAQ---------------------SilqrkiIWTahdy---prggGVVEH-R-QERMP 118 Postia placenta...
XP_004993792  83 EGVLYG--D---AS-Q-----QAQV---------------------A------SWDp----------ERVERlM-QPLDE 113 Salpingoeca ros...
XP_001886252  75 SNALGEV-D---DV-EdesgsESAP---------------------G------PWTg----------GIVEY-R-QTRMA 110 Laccaria bicolo...
XP_001758033  76 AGSLYEY-S---PQlQ-----SSSV---------------------N------TCFs----------SIE-F-Q-STNVP 106 Physcomitrella ...
XP_002173475  75 NSKLLQP-D---IV-E-----NNNNidifgyakndnrktgegpedvN------TWSg----------KTVCV-E-APPLP 126 Schizosaccharom...
EGA73548      75 YQYSESQ-D---YH-F-----GNED---------------------K------FKE-----------QTVIK-T-HPRIP 104 Saccharomyces c...
Q16X91       114 KSEYQRDLGE 123 yellow fever mosquito
Q9P6K5       106 VHPYQEALWS 115 Schizosaccharomyces pombe 972h-
Q018N1       104 RSAYARALER 113 Ostreococcus tauri
Q5A2W2       119 KNEYQQKLDQ 128 Candida albicans SC5314
XP_002471242 119 KSRYQQRLDD 128 Postia placenta Mad-698-R
XP_004993792 114 PSPYHQHLEQ 123 Salpingoeca rosetta
XP_001886252 111 KSVYQNRMED 120 Laccaria bicolor S238N-H82
XP_001758033 107 ESSRSRDIap 116 Physcomitrella patens
XP_002173475 127 LHPYQAWLDQ 136 Schizosaccharomyces japonicus yFS275
EGA73548     105 KSEYQSSLDA 114 Saccharomyces cerevisiae AWRI796
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