Conserved Protein Domain Family
Misat_Tub_SegII

?
pfam10644: Misat_Tub_SegII 
Misato Segment II tubulin-like domain
The misato protein contains three distinct, conserved domains, segments I, II and III. Segments I and III are common to Tubulins pfam00091, but segment II aligns with myosin heavy chain sequences from D. melanogaster (PIR C35815), rabbit (SP P04460), and human (PIR S12458). Segment II of misato is a major contributor to its greater length compared with the various tubulins. The most significant sequence similarities to this 54-amino acid region are from a motif found in the heavy chains of myosins from different organisms. A comparison of segment II with the vertebrate myosin heavy chains reveals that it is homologous to a myosin peptide in the hinge region linking the S2 and LMM domains. Segment II also contains heptad repeats which are characteristic of the myosin tail alpha-helical coiled-coils. This myosin-like homology may be due only to the fact that both myosin and Misato carry coiled-coils, which appear similar but are not necessarily homologous (Wood V, personal communication).
Statistics
?
Aligned: 45 rows
Threshold Bit Score: 106.953
Threshold Setting Gi: 74590322
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
WGS:AAPP:GF20926-PA   5 REILSLQLGTYANYVGAHFWNQQEANF--CYGDGDGDdqv-aeEHLlHNDILYREGLN--S-HNRTTYTPRLVSVDLAGT 78  Drosophi...
XP_019076799          2 REIVTIQVGGFANFIGSHFWNFQDELLglAGDPNGDPif--knQHL-DMDVLYRTGET--L-QGIATYTPRLVSVNFQGS 75  wine grape
Q10PA8                2 REAVTVQVGGFANYVGSHFWNFQDELLglADDPDADPvf--knDAL-DMDVLYRSGET--H-QGIPTYCPRLVSVGSRGS 75  Japanese...
XP_015576762          2 REIVTVQVGGFANFIGSHFWNFQDELLglATDPDSDPvfkhcaDYL-NMDVLYRNGET--Q-QGIHTYTPRLISINGQGS 77  castor bean
EFI95584              2 REIVYIQSGNLANYVGSHFWNTQECYL--T--DEDE-------TPY-DRRMSFRESLAdsG-KGAICYSPRALIFDHKSN 68  Schizoph...
Q9P6K5                2 HEILTVTFGRKSNFCWTHFWNTQESYF--VYDPNDH-------AKV-NVNTNFRVLKK--RdPEAIVTVPRECIYDTPIE 69  Schizosa...
WGS:AATM:SJAG_02265   2 HEILSFAFGGKSNFVSTHFWNAQEKYL----DQGND-------AQI-DREVAFFERKTnnI-GGDVVFHPRTLIYDDRDA 68  Schizosa...
Q018N1                3 SSVVTASFGTHAASVAAHFWNVRED----DSDENDEVd-----WNV-DHAERARVNEG----STSISYVPRWVAFDARSL 68  Ostreoco...
Q5A2W2                2 SEIITLSYGSICNNTVTHLYNTQESLI--SYTPSSKP----------NHDLQVFL--TrfK-STSVSYSPRALIYDLRNG 66  Candida ...
EGD73510              7 GEVITLQFGNYANHVGAHFWNLQDAMI--DYTGQEPEs----eDPI-SHDVLFRCGET--P-SGAPTYTPRLLLYDLRDS 76  Salpingo...
WGS:AAPP:GF20926-PA  79 LAHLPLGGELYGnfvqrdeellpfgtgedlnktRQRVE-ESGVAPTS-----------QLELQE-EPPTQLSEYQRDLMK 145 Drosophi...
XP_019076799         76 LGSMSSHGTLYD---------------------HNPPV-PSHVVTWPg----------NVSTHL-SEPHKKNLFLQSLYE 122 wine grape
Q10PA8               76 LGSLSSSGNLGQ---------------------TSASAdQLNVATWSg----------SVTRSV-SKPHGRNLFLQSLVE 123 Japanese...
XP_015576762         78 LGSMSSHGTLYT---------------------DGSST-SSEVITWTg----------NISTHA-SGPSKKNLFLQSLSE 124 castor bean
EFI95584             69 FGTFAKSNILSSte-----------------ndQSPDT-AAVASLWKg----------AVDEQQ-SDPIPKSDYHAKLER 119 Schizoph...
Q9P6K5               70 FGNTRK-NWLEE---------------------LNESS-GGKGTAWDg----------KLTQIM-QTPVDVHPYQEALWS 115 Schizosa...
WGS:AATM:SJAG_02265  69 FGTTIKNSKLLQpdivennnnidifgyakndnrKTGEG-PEDVNTWSg----------KTVCVE-APPLPLHPYQAWLDQ 136 Schizosa...
Q018N1               69 RGKTTATGLSSG-----------------------DAA-AAAAAAWSg----------AWTVTR-APPTRRSAYARALER 113 Ostreoco...
Q5A2W2               67 LGALNKYEYHETlp-----------------vdLNFSL-LSTNTTAPagaetgagsslESGYNLkKSRVEKNEYQQKLDQ 128 Candida ...
EGD73510             77 TSALSQEGVLYG----------------------DASQ-QAQVASWDp----------ERVERLmQPLDEPSPYHQHLEQ 123 Salpingo...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap