1SRA


Conserved Protein Domain Family
SPARC_Ca_bdg

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pfam10591: SPARC_Ca_bdg 
Secreted protein acidic and rich in cysteine Ca binding region
The SPARC_Ca_bdg domain of Secreted Protein Acidic and Rich in Cysteine is responsible for the anti-spreading activity of human urothelial cells. It is rich in alpha-helices. This extracellular calcium-binding domain contains two EF-hands that each coordinates one Ca2+ ion, forming a helix-loop-helix structure that not only drives the conformation of the protein but is also necessary for biological activity. The anti-spreading activity was dependent on the coordination of Ca2+ by a Glu residue at the Z position of EF-hand 2.
Statistics
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Aligned: 21 rows
Threshold Bit Score: 106.273
Threshold Setting Gi: 74800039
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1SRA_A         1 PPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNnlltekqklrvkk-ihenekrleagdHPVELLARDFEKNYNMYIFPV 79 
CAF94164     111 NCTGQDLADLGDRLKDWFQLLHGNAKQNNSGRP--------------------------GSGTSSALDRSLGASCKDSIG 164 spotted green p...
EDO37293     111 SECARDNLLQFGERYLEWILISRRRLVNRYYQV-----------------------------KESEKGHNLPPDMRKELA 161 starlet sea ane...
XP_001626442 110 TDCPKWMLEQFPYRFLDWLYLTRELSRDPRFEI-------------------------------AKRGEQLTGDEIKEVL 158 starlet sea ane...
CAP39116     139 DECTEEHMAQFPERMADWLFQVMKELKKRRELHk------------------------lEWEELLSEAENDDEKKHVYPV 194 Caenorhabditis ...
XP_002023777 166 RICDGEDLKEFPRRMRDWLFNVMRDLAERDELTe-------------------------HYMQMELEAETNNSRRWSNAA 220 Drosophila pers...
Q1HPY3       182 PDCTESEMSDFPRRMRDWLFNIMRDMAERRELTp-------------------------HYLKMEREAESNLTRRWANAA 236 domestic silkworm
Q16II0       178 PDCSENDLADFPRRMRDWLFNVMRDLAVRNELPe-------------------------AYMELEQEAESNLTKRWTNAA 232 yellow fever mo...
BAF56044     149 GSCSAEDLREYPERMTNWFIKSLALIRNRPEEHg-------------------------GLSQKEKETLQQEWSQSTHAI 203 purple sea urchin
NP_001027592 214 QPCGEHELSEYPTRMRSWIKNIYLQMYDEAEDMgglnekqrfhgrklvanrdrlqtyeeHHIDLMSREFQKFYPLYKYPI 293 vase tunicate
1SRA_A        80 HWQFGQLDQHpIDGYLSHTELAPLRAplIPMEHCTTRFFETCDLDNDKYIALDEWA 135
CAF94164     165 WMFSKLDTDS-DLYLGQAELTAINLD--KYEICIRPFFNSCDTYKDGKISMAEWCL 217 spotted green pufferfish
EDO37293     162 QWEFDRVDFN-RDGVLSGREINSIIGplLFHERCIYGFVMSCDVNKNSVIDKQEWL 216 starlet sea anemone
XP_001626442 159 AWEFNNWDLN-KNGIWDKEELDLVQTilMPIEGCSFGFLKSCDLDGKGDMDRREWM 213 starlet sea anemone
CAP39116     195 IWKFCELDTKpHDKSVSHHELIPITApvIPMESCIKPFLEGCDANNDGNISIKEWG 250 Caenorhabditis briggsae
XP_002023777 221 VWKWCDLDGD-TDRSVSRHELFPIRAplVSLEHCIAPFLESCDSNNDHRITLIEWG 275 Drosophila persimilis
Q1HPY3       237 IWKWCDLDAQtNDRFVSRHELFPIRAplMALEHCIAPFLDRCDADDDHRVTLAEWG 292 domestic silkworm
Q16II0       233 IWKWCDLDGHpNDNSVSRHELFPIRAplMTLEHCIAPFLETCDPNGDHRITLQEWG 288 yellow fever mosquito
BAF56044     204 FWKFDRLDKNpSDHYLDFAELEGLRApiVLFEPCTKPFLQACDVDNDTLISAVEFG 259 purple sea urchin
NP_001027592 294 HWKFGILDVNpTDKYLSKRELEPMRAplVPLEHCTDTFFSTADANKDHLISLYEWA 349 vase tunicate
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