1SRA


Conserved Protein Domain Family
SPARC_Ca_bdg

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pfam10591: SPARC_Ca_bdg 
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Secreted protein acidic and rich in cysteine Ca binding region
The SPARC_Ca_bdg domain of Secreted Protein Acidic and Rich in Cysteine is responsible for the anti-spreading activity of human urothelial cells. It is rich in alpha-helices. This extracellular calcium-binding domain contains two EF-hands that each coordinates one Ca2+ ion, forming a helix-loop-helix structure that not only drives the conformation of the protein but is also necessary for biological activity. The anti-spreading activity was dependent on the coordination of Ca2+ by a Glu residue at the Z position of EF-hand 2.
Statistics
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PSSM-Id: 313749
View PSSM: pfam10591
Aligned: 22 rows
Threshold Bit Score: 113.95
Threshold Setting Gi: 74800039
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1SRA_A         1 PPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNnlltekqklrvkk-ihenekrleagdHPVELLARDFEKNYNMYIFPV 79  human
Q29BA1       166 RICDGEDLKEFPRRMRDWLFNVMRDLAERDELTe-------------------------HYMQMELEAETNNSRRWSNAA 220 Drosophila pseu...
Q1HPY3       182 PDCTESEMSDFPRRMRDWLFNIMRDMAERRELTp-------------------------HYLKMEREAESNLTRRWANAA 236 domestic silkworm
Q16II0       178 PDCSENDLADFPRRMRDWLFNVMRDLAVRNELPe-------------------------AYMELEQEAESNLTKRWTNAA 232 yellow fever mo...
NP_001294588  52 DECTEEHMAQFPERMADWLFQVMKELKKRRELHk------------------------lEWEELLSEAENDDEKKHVYPV 107 Caenorhabditis ...
NP_001027592 214 QPCGEHELSEYPTRMRSWIKNIYLQMYDEAEDMgglnekqrfhgrklvanrdrlqtyeeHHIDLMSREFQKFYPLYKYPI 293 vase tunicate
NP_001091924 149 gSCSAEDLREYPERMTNWFIKSLALIRNRPEEHg-------------------------GLSQKEKETLQQEWSQSTHAI 203 purple sea urchin
XP_001629356 111 SECARDNLLQFGERYLEWILISRRRLVNRYYQ-----------------------------VKESEKGHNLPPDMRKELA 161 starlet sea ane...
XP_001626442 110 TDCPKWMLEQFPYRFLDWLYLTRELSRDPRFEI-------------------------------AKRGEQLTGDEIKEVL 158 starlet sea ane...
XP_003205615 524 PHCTDYEVGQFPLRMRDWLKNILMQYYERDQDKpgfltekqrnkvkkiylnekrlvsgeHPVELLLHDFEKNYHMYVYPV 603 turkey
1SRA_A        80 HWQFGQLDQHpIDGYLSHTELAPLRAplIPMEHCTTRFFETCDLDNDKYIALDEWA 135 human
Q29BA1       221 VWKWCDLDGD-TDRSVSRHELFPIRAplVSLEHCIAPFLESCDSNNDHRITLIEWG 275 Drosophila pseudoobscura
Q1HPY3       237 IWKWCDLDAQtNDRFVSRHELFPIRAplMALEHCIAPFLDRCDADDDHRVTLAEWG 292 domestic silkworm
Q16II0       233 IWKWCDLDGHpNDNSVSRHELFPIRAplMTLEHCIAPFLETCDPNGDHRITLQEWG 288 yellow fever mosquito
NP_001294588 108 IWKFCELDTKpHDKSVSHHELIPITApvIPMESCIKPFLEGCDANNDGNISIKEWG 163 Caenorhabditis elegans
NP_001027592 294 HWKFGILDVNpTDKYLSKRELEPMRAplVPLEHCTDTFFSTADANKDHLISLYEWA 349 vase tunicate
NP_001091924 204 FWKFDRLDKNpSDHYLDFAELEGLRApiVLFEPCTKPFLQACDVDNDTLISAVEFG 259 purple sea urchin
XP_001629356 162 QWEFDRVDFN-RDGVLSGREINSIIGplLFHERCIYGFVMSCDVNKNSVIDKQEWl 216 starlet sea anemone
XP_001626442 159 AWEFNNWDLN-KNGIWDKEELDLVQTilMPIEGCSFGFLKSCDLDGKGDMDRREWM 213 starlet sea anemone
XP_003205615 604 HWQFYQLDQHpIDRSLTHSELAPLRAslVPMEHCITRFFQECDGDQDKLITLKEWC 659 turkey
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