Conserved Protein Domain Family
PIG-S

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pfam10510: PIG-S 
Phosphatidylinositol-glycan biosynthesis class S protein
PIG-S is one of several key, core, components of the glycosylphosphatidylinositol (GPI) trans-amidase complex that mediates GPI anchoring in the endoplasmic reticulum. Anchoring occurs when a protein's C-terminal GPI attachment signal peptide is replaced with a pre-assembled GPI. Mammalian GPITransamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG-T, and PIG-U, all five of which are required for function. It is possible that Gaa1, Gpi8, PIG-S, and PIG-T form a tightly associated core that is only weakly associated with PIG-U. The exact function of PIG-S is unclear.
Statistics
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Aligned: 104 rows
Threshold Bit Score: 257.957
Threshold Setting Gi: 307769097
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
GAC96405      18 TCFWVALLASIPSWLRLTTIQRLPLPTKQVEALHYPD---DCPVAFQssLTVS-VDPTIISEdggqe--egekDAQASFL 91  Pseudozyma hube...
XP_012811796  22 SIALITAVLGLPLWWKTTETYRASLPYSDIRGLET-L---QLHLTVP--IEII-FGKATLTA-----------EQQRNVP 83  tropical clawed...
XP_006005796  22 SIAAIAILLGIPLWWKTTETYRASLPYSQIRELDT-L---WFQLMVP--VEVI-FAKGTLRA-----------EQQRQIP 83  coelacanth
EDV23754      17 AVGVVIIVLGVPLWWVTTEVYRAPLPYNRIAQLAF-L---QPQSVVP--VEVVwLTKGEGVT-----------EESTKLS 79  Trichoplax adha...
XP_015790285  47 FYIIVIVVVGLPVWFKTTSPSRYSLP--DVASLMVHLqttVNAVDINvvIGVD-LDRQSLVSqlppnhissdgSVAYKID 123 two-spotted spi...
EFO28331      46 AFIVIVLIFGLPLWWQTTSTYRAPF-----RTFSSDQ-----QIVLP--VYISiASSHSSMK-----------SHIGRAI 102 eye worm
EGT37906      60 SFVILVFLIGMPMWYYTTSTYRAPFP-----TFSANR-----SVTVP--IRVNvAIASSQIT-----------VDMEQLL 116 Caenorhabditis ...
XP_002124261  25 ATGLIFVVLGVPIWWNTTKVYRANLPFTEIAELNQDA---GLKVGIN--VNVV-VADNCDFE-----------AVKSKLE 87  vase tunicate
XP_005056851  23 SFATIAVVLGLPLWWKTTETYRAALPYADIDGLGQ-Q---PVRLVVP--MAVV-FGPGSVPR-----------DLSRSLP 84  collared flycat...
XP_001507200  22 SFATVAIVVGLPLWWKTTETYRASLPYSQISQLGD-L---RLQLTVP--ISVV-FAKGALPI-----------EAQRKLP 83  platypus
GAC96405      92 KQVEQLVQQSLeikAglpaaASLectrWKVDVHATSSAGSL-----------------PPLDLETGAYAVRVASETs--- 151 Pseudozyma hube...
XP_012811796  84 -STGLKETETVlnaQ-----TSItr-hYEFKYRRTSVDE-EealglkslqdannalqkLGE-TAHGSITIFILPESsvll 154 tropical clawed...
XP_006005796  84 -FSQSRQKEAQlnsK-----TGFry-rYETKFRAATAME-EtalalpgvqeaeetlsrLKE-TPEGTVLVYIIPETslll 154 coelacanth
EDV23754      80 ELLKANLKSASsdnM-----TIIdy-iITTRVGNEMEME-IvkenlialneldrklgaLNP-ESQG-FRFYLLRPSqiks 150 Trichoplax adha...
XP_015790285 124 WRVRKMTPKEEdvwS-----KSKsldsFDQELAKLESHQKP------------------------GRIYIFLVDMN---- 170 two-spotted spi...
EFO28331     103 TLLLNELSELPvidR-----LRLifklNHEDMDALEFISRA-------------------NKEVSNLFGVHVAVINetvw 158 eye worm
EGT37906     117 SEIKQNMTTKEvvfP-----LKFdwttEFIGIKTFEELEQDh---------------sVKVEDNKDFFDVFIALVPekdw 176 Caenorhabditis ...
XP_002124261  88 DYFGNFGGSVSakpI-----Fv----kYNVTYSP--KSVDL-----------------GLEGEVAGTIRVAVSCGNfd-- 137 vase tunicate
XP_005056851  85 -FTDVQEMEISvnlR-----TTVts-rYEMRYRSTTAQE-EaalfaatareadaalhpLQD-TTMGSLTMYVVPETssll 155 collared flycat...
XP_001507200  84 -YTDTQERKIPlnyK-----MTInc-lFEKSYRNTIDQE-EvalglanvqeadavlslVQE-SPEGMLTVYVVPEAssll 154 platypus
GAC96405     152 ------sDDADAHQSGVPTV----YLPNPTdepaslplVP-DTVSAAVIAEL--LHLRGDKppsTAADDtsasTISDT-- 216 Pseudozyma hube...
XP_012811796 155 ----pkgIRVYIGKHRIALV----R--CALstslgsedIA-NTVYKKVEHVI--QTMSFTD---EAVTAalsdRIPIG-- 216 tropical clawed...
XP_006005796 155 ----pqgIKTYIGKRRTAVL----R--AVLsqshrmedTL-DEISPQVQRVV--QTMSFTD---DVIASavsdRIPIG-- 216 coelacanth
EDV23754     151 -----pinRIYVGSYYSTFI----V----LndgeryesFA-TKIQLVVKDIY--VNEKVLR---NTVTSilgfRekka-- 209 Trichoplax adha...
XP_015790285 171 --------NVRKLGKSVTVLgsnrFIYIGVrdeemsvvDA-DEDKSLIMYILdaLETVLEAkhdRLLTSasdiDEKEN-- 239 two-spotted spi...
EFO28331     159 p--ysgyTTYFDDQWTFILNc----------------eDE-SKLAQRMFEAI--TDVLLDTshlSAIVRrdlrQGIQS-- 215 eye worm
EGT37906     177 shysatrIQLGIGKWNFVQWptk-------------eeEK-RKASSRITELI--SEILIDIphlNSIVRrdlrQKMQP-- 238 Caenorhabditis ...
XP_002124261 138 ------dFKINVETNREISA----QIGRKT--------ENlDEFGKILVEVL--KQGVVGEemlEEVVAnirkEGGSGrk 197 vase tunicate
XP_005056851 156 ----pqgINVYVGKHRSALV----Rav----------gSL-AALQARLREVT--QVMSFTA---SSIAAalsdRLPSR-- 209 collared flycat...
XP_001507200 155 ----pqdVMGYVGKRRGAVV----Rgar-------gqqAL-ALVEQRVQQVI--QATSVTD---DVLAAaladRLSGD-- 211 platypus
GAC96405     217 Q------------HdPRVIQYSKHVRLVFSIMNQDVTDg-sAYDSQlvhDLASAnas-tsnPITRLTSELSGLHDFHVET 282 Pseudozyma hube...
XP_012811796 217 Kfske----dfenS-RRAFKSSAGYEITFSLLNPDPKShdlNWNIS---SASDQ-------YIQPFLDKLQNVANFSMDS 281 tropical clawed...
XP_006005796 217 Kfnke----tyadN-MKALKSSLGYEITFSLLNPDPKShdlHWDIE---NAVNY-------YIQPFLGKLSSMANFSMDS 281 coelacanth
EDV23754     210 ----------dveS-MRAIRSTDSYQLSFTLINPEPHNliaKWKIA---DAIRI-------YLDPFLKALKDFSSFTIDS 268 Trichoplax adha...
XP_015790285 240 ----------------IKYLLNREVNLIVNFISEDIED---STNFKtrqLISDArklgeeaFIQH--SGISNLISINFMS 298 two-spotted spi...
EFO28331     216 SkvsalssrqqkrLiWDSVALSARYIVQVIFLHAGYNEsseHYSAE---NIIL--------HARRFAAKLAEVSDLIISS 284 eye worm
EGT37906     239 WqiaalplshqkrLvWDSAPLATAYHIQIIHLHENTEVsmdLLGAQ---EKTAK-------AFRKFAEKVEGVTKVEVSF 308 Caenorhabditis ...
XP_002124261 198 De----------eL-MKMVPPSSEFEVIFTLLCPDAEKm--TWDVE---RAILE-------HITPILEELKPIFHFHISS 254 vase tunicate
XP_005056851 210 Qlg--------pdA-RRNLKSSLGYEITFSLLNPDPKShtvDWDIE---GAVNR-------YVKPVLDKLSLVANFSVDS 270 collared flycat...
XP_001507200 212 Kws--------sdR-RRPLKSSLGYEITFSLLNPDPRShdvRWAIE---GAVRH-------YVQPFLDKLRPAANFSVDS 272 platypus
GAC96405     283 QVQWFAPlqfqp---treilEEVveidveeevmvdqeveevVEVEvdnedpaegevasastieadaeaseverelpsaps 359 Pseudozyma hube...
XP_012811796 282 QTLYYAMlgvt------prfEKSt----------------sS-YI----------------------------------- 303 tropical clawed...
XP_006005796 282 QILYYAIlgvt------prhDKAs----------------sS-YI----------------------------------- 303 coelacanth
EDV23754     269 QVLYYSGlsir------psqDSAt----------------gS-YY----------------------------------- 290 Trichoplax adha...
XP_015790285 299 QMVYYGFd---------------------------------sNFIdknlvtdsn-------------------------- 319 two-spotted spi...
EFO28331     285 EHLWDFDltawlk-kdvqgrNTI--------------------------------------------------------- 306 eye worm
EGT37906     309 EHLWDFEtttqflakdvqerWTL--------------------------------------------------------- 331 Caenorhabditis ...
XP_002124261 255 QVLYSTKlrvrpkimknsttNEV------------------KYHY----------------------------------- 281 vase tunicate
XP_005056851 271 QILYYAVlgvt------pryDKEs----------------sS-FL----------------------------------- 292 collared flycat...
XP_001507200 273 QILYYAMlgvt------pryDTAs----------------aS-YV----------------------------------- 294 platypus
GAC96405     360 tgrrkktikqtqkrtiqvpriqhtrkqkrtplpprnVvEWDDLKVFVNSQEWSLTSTVppsSSSSQrnhtvdgrpydils 439 Pseudozyma hube...
XP_012811796 304 ------------------------------------L-NLHNLPHVINPVEARLGSSAa--SLYPV-------------- 330 tropical clawed...
XP_006005796 304 ------------------------------------L-SAESLPHVINPVEARFGSSAa--SLYPV-------------- 330 coelacanth
EDV23754     291 ------------------------------------L-TPRLLPRVINSIESRLGSHAt--N-NPA-------------- 316 Trichoplax adha...
XP_015790285 320 ----------------------------gpsagnerLfDKARVGLLLNAIESRIVEP----NIKLT-------------- 353 two-spotted spi...
EFO28331     307 --------------------------------------QMDDISQIVTAIEQETSTVE---SSAPV-------------- 331 eye worm
EGT37906     332 --------------------------------------THSAMEELVKKVDAQMQTSL---EQGTV-------------- 356 Caenorhabditis ...
XP_002124261 282 ------------------------------------L-QGNQLSNIINSIESRLGSHL---STFPT-------------- 307 vase tunicate
XP_005056851 293 ------------------------------------L-SAHSLPHVINPVEARLGSSAa--SLYPV-------------- 319 collared flycat...
XP_001507200 295 ------------------------------------L-PVHSLPHVINPVEARLGSSAa--SLYPV-------------- 321 platypus
GAC96405     440 qthdLHFLLYIP-SKSNTPLfIRDIVkGGveeagGWLIPQ--WGGVVILNAEDdpaeenglishhqgaggggggkVIELS 516 Pseudozyma hube...
XP_012811796 331 ----LNFLLYVP-EYSHSPLyIQDKDgSRip-tnAFHSPR--WGGIMIYNVDYgnlg--------------elqfPVHID 388 tropical clawed...
XP_006005796 331 ----LNFLLYVP-DYAHSPLhIRDHHgAQvt-tnAFHSPR--WGGIMVYNVKHknsn--------------etlfPIRVD 388 coelacanth
EDV23754     317 ----ANFILYVP-ETKFKNLhIRTSKnDSrm-tySFISPR--WGGFII---DSkahn--------------alntSKVYE 371 Trichoplax adha...
XP_015790285 354 ----YHLHVIIPsSSKNSSVyFYDKEsKs----kSFAAETtyRAGIFFWNKENdfn------------------------ 401 two-spotted spi...
EFO28331     332 ----MKLVVLD----APQPLaLLDYMgDEs---nGLVVAS--WGALL------------------------------SYA 368 eye worm
EGT37906     357 ----LRFVILE----TVEPViFLDETgEDv---hGVAVAS--WGAVL--------------------------------- 390 Caenorhabditis ...
XP_002124261 308 ----LNFVLYLT-DISNNPLyIQKGDgSPsk-snNFLLPR--WGGMTIYNPQEga------------------reV---- 357 vase tunicate
XP_005056851 320 ----LNFLLYVP-ERSHSPLyIQDKDgAPvs-tnAFHSPR--WGGIMVYNVEVpasp--------------qaslPLHVD 377 collared flycat...
XP_001507200 322 ----LNFLLYVP-DRSHSPLyIQDKDgAPva-tnAFHSPR--WGGIMIYNVDLsasn--------------atelPVRVE 379 platypus
GAC96405     517 EAKVVGAMTLFSRQLEILLGLSdi-----pTs------------PLqr------niRLSTLQQRRTLELARETTSTLTAI 573 Pseudozyma hube...
XP_012811796 389 ID-MVRVMEVFLTQLRLLLGITkaavpedyQl------------Espgne-gltdwELDSLLWSRVVENIATVTTTLTSL 454 tropical clawed...
XP_006005796 389 ID-MVRVMEVFLTQLRLLLGIQkvetpadvLl------------Qspgne-gitdwELDRLLWVRTVENIATATTTLTSL 454 coelacanth
EDV23754     372 VD-LKEAMDIFVAHLKLLLGIPkismsgdkRl------------EfgksdvglskwEYSCLLRRRTLENVASANQTLTSL 438 Trichoplax adha...
XP_015790285 402 --------laFKSFMRNLLGISsiqpsn-----------sirrniFfs------qwELDYLMRQMTLQHLAKTLSSLESI 456 two-spotted spi...
EFO28331     369 GQRRLAVNQSVIAAMRALFGLDtdlpvssdr-----------------splpvanwEIKRIKLRSFVDCSINGMSSVAAI 431 eye worm
EGT37906     391 -PRTELTESKAISAMRIQMGMDaellpgwhr-----------------ppvavcqwEIARARLRASVDNAMRAASAIRAL 452 Caenorhabditis ...
XP_002124261 358 --DLDSVMPTFLTNLRTLVGLRnn-----yPnidkqvifkpptwPGit------gwETDYLLRLRSVENVATSTNTLGSL 424 vase tunicate
XP_005056851 378 VD-MARVMEVFLAQLRLLFGLSreevppefLl------------Espgne-gladwELDHLLWAHTVENIATVSTTLTSL 443 collared flycat...
XP_001507200 380 VD-MVRVMEVFLAQLRLLFGISqaqvpadfQl------------Enpgne-glaawELDRLLWARTVENIATVATTLTSL 445 platypus
GAC96405     574 TRLVDRIENLGVGPPVKSDVQSSLDIIQSLAAAQnETqslSELFERTREAHALSNRAFFNPDMLGLLYFPDEHKYAVYTP 653 Pseudozyma hube...
XP_012811796 455 AQLLDQIGNIVINDIVASEVYHAVSSVQTALSEL-EAgrlESAFQASKEAISSSEKAFFDPSLLHLLYFPDDQKFAIYIP 533 tropical clawed...
XP_006005796 455 AQLLDQIGNIVINDHIASEVYSSVASVHATLSEL-EAgrlSSAFHASKQAITSSERAFFDPSLLHLLYFPDDQKFAIYIP 533 coelacanth
EDV23754     439 AKLLEEITNIVISDRIKELINLSIEELHKSLDFM-KSgdnARAFAHSKTAVTNSEKAFFDASLLELLYFPSDQKFAVYVP 517 Trichoplax adha...
XP_015790285 457 DKLLGKLKNIVIFKEIADKMNTAAELSHHSIDLLsEgn-lMRANELSGKAFDASESAFYDPSLLSRLYFPEDQKYAVYFP 535 two-spotted spi...
EFO28331     432 HKLVSQIDNIVINEEMASKTNLAVELISQALLTVeKIgd--iDVASVTQGRALAESALNDKSLLSLLYFPNDQKFAIYLP 509 eye worm
EGT37906     453 DQLAQKISNIAINDDVADRAKRAVSILDSTVKPgrm-ldfEKLL----EARRLADSANNDHSLLAMLYFPMDQRTAVLIP 527 Caenorhabditis ...
XP_002124261 425 EKLLHQIDNIIINDDVADSVFQSVAAIVEAKQAI-SVgnlTRAMSSSRDAFVSSQSAFFHPSLLELLYFPEDQKFAIYVP 503 vase tunicate
XP_005056851 444 AQLLDKIGNIVIKDDVASEVYQAVASVQSAVTKL-SLghlQAAFQASKEAVTSSERAFFDPSLLHLLYFPDDQKFAIYIP 522 collared flycat...
XP_001507200 446 AQLLDKIGNIVIKDDVASEVYQAVEAAQSAAAEL-EAgrlGPAFQASRTAVTSSERAFFDPSLLHLLYFPDDQKFAIYIP 524 platypus
GAC96405     654 LFAPLLVPLIVTTVKLLKELAET 676 Pseudozyma hubeiensis SY62
XP_012811796 534 LFLPMAVPIFLSLIKIAKEYKQS 556 tropical clawed frog
XP_006005796 534 LFLPMAVPIILSLLRIASDFRQA 556 coelacanth
EDV23754     518 LFLPISLPILQSLYHAIRFLYRQ 540 Trichoplax adhaerens
XP_015790285 536 LFLPVSVPLVLSIWHLIRMYYKR 558 two-spotted spider mite
EFO28331     510 LFLPTLLPLFGSILALNRywmgk 532 eye worm
EGT37906     528 LAVPIVLPILKLMFEIAmvlirg 550 Caenorhabditis brenneri
XP_002124261 504 LFLPISLPVLVSLVFVYKRYKNK 526 vase tunicate
XP_005056851 523 LFLPMAVPILLSLAKIVRETRLR 545 collared flycatcher
XP_001507200 525 LFLPMAVPILLSLVKILREARQA 547 platypus
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