Conserved Protein Domain Family
Proteasom_PSMB

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pfam10508: Proteasom_PSMB 
Proteasome non-ATPase 26S subunit
The 26S proteasome, a eukaryotic ATP-dependent, dumb-bell shaped, protease complex with a molecular mass of approx 20kDa consists of a central 20S proteasome,functioning as a catalytic machine, and two large V-shaped terminal modules, having possible regulatory roles,composed of multiple subunits of 25- 110 kDa attached to the central portion in opposite orientations. It is responsible for degradation of abnormal intracellular proteins, including oxidatively damaged proteins, and may play a role as a component of a cellular anti-oxidative system. Expression of catalytic core subunits including PSMB5 and peptidase activities of the proteasome were elevated following incubation with 3-methylcholanthrene. The 20S proteasome comprises a cylindrical stack of four rings, two outer rings formed by seven alpha-subunits (alpha1-alpha7) and two inner rings of seven beta-subunits (beta1-beta7). Two outer rings of alpha subunits maintain structure, while the central beta rings contain the proteolytic active core subunits beta1 (PSMB6), beta2 (PSMB7), and beta5 (PSMB5). Expression of PSMB5 can be altered by chemical reactants, such as 3-methylcholanthrene.
Statistics
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PSSM-Id: 313688
View PSSM: pfam10508
Aligned: 7 rows
Threshold Bit Score: 545.099
Threshold Setting Gi: 74964288
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q16401         1 MAAQALALLREVARL--EAPLEELRALHSVLQAVP-LNELRQQAaelr--lgpLFSLLN--ENhrekt----tlcvSILE 69  human
Q20058        11 IEEWRNDYIAERSSKkgWEILEKLAKMQIEAAQQMeTEDDVAAA---------DFDDFS--TS-------------KLVK 66  Caenorhabditis ...
Q16R63         2 DENLCQELLANLQLE--QTRKTALTEIKNTLISSSnASAISNSFlks----peLLNCLE--DAnseqt----llacDILS 69  yellow fever mo...
Q9VYG1         4 EDNWWVTKLKALESK--PQRLDALTAMNSAIAKEA---ALPRQIierllttdqLYDCANpaADshvpkdqavdvtlELLC 78  fruit fly
XP_001626658   2 AAEKCKELVENISNAsgDEIVAFLRDLSVLISSSPnIRDLASLIps-----erLFNCLR--TTntdqi----tyckNILK 70  starlet sea ane...
XP_002642096  11 IEGWRNDYVSNRNSKkgWEILENLVKMQTEGNQQMeTDEMSENCa--------AFDDFS--TN-------------QLIK 67  Caenorhabditis ...
XP_003965288   1 MAATIEGLLGEISGV--EHPTEELQLLKTALLSIP-VNALRDAVsgqr--fnvIFALLN--SDcreqv----elcvDILE 69  torafugu
Q16401        70 RLLQAMEPVHVARNLRVDLQRGLIHPDDSVKILtl----sqIGRIVENSDAVTEILNNAELLKQIVYCIGGENLSVAKAA 145 human
Q20058        67 LIIGDISTKDLLVDHQIILLEFIPSAHPNILRH--------VVRTVREKEGAISLLKSSSVAIGVAFARRVTDAEAGEEV 138 Caenorhabditis ...
Q16R63        70 ICMSTLAIDE-SSEVKNVIEKSLSHVNPRVQAFgl----reLRRIVQSRSA--DGFVNETLILLVIKCLASDDTSVGTPA 142 yellow fever mo...
Q9VYG1        79 HCLDQLAMDTADEQLSSLLRRGLTHSNPALRAQvlaslfkkLLR--QLTVGQVLTLPNNELIFLILDELKQPDTQSTSLA 156 fruit fly
XP_001626658  71 NILKFEKPDAPATKYHDAVIEGLNHPTEDVRELcl----ieLERCSGTVNGVLALMDKEDLLSYIARGMADEHLKNAQIA 146 starlet sea ane...
XP_002642096  68 LIIGDFTVKDLLVDHQVVLLEFIPSAHPNILRH--------VARIIREKEGALPFLKTESIAVGIAFARRITDSDAGEEI 139 Caenorhabditis ...
XP_003965288  70 RILIALSPVCLVQKYRAELQAGLTHPNDTVKILal----tqIGRILEHPDAATEVLNNHDVLQAVIQCIREEKIAVAKQA 145 torafugu
Q16401       146 IKSLSRISLTQAGLEALfesnlLDDLKSVMKT-N-DIVRYRVYELIIEISSVSPESLNYCTtsgLVTQLLRELTG-EDVL 222 human
Q20058       139 GRLMAHLVDHDLINEEL-----KSQLSVANGReS-SSIRSRIYSIATERARISSNTSCIHW---LYDKILKSVLDtQDVL 209 Caenorhabditis ...
Q16R63       143 IELLRLMLPRFVQLRSV-----SENLEGLLDK-G-DVVRCRLYELAVRLAKQSEELLAAMDk--FLKKAVQELDG-EDVL 212 yellow fever mo...
Q9VYG1       157 INILSIVLPQRISNADV-----QAKLVQLLKQ-N-EIVRCRAYELAVVLAKKSATLLSDVTf--ILDAALSELDN-DDVL 226 fruit fly
XP_001626658 147 SNVFTNLAKHEAGLKVLfdshlQSEFNALLKT-K-DTVRMRVYDMYITVQAHSPKAFDVCKesgIFEKLISELDG-RDVL 223 starlet sea ane...
XP_002642096 140 GRLLAHLVDNEKICDEL-----KFILKNNTGR-NnAMNRASIFSIATERAGISADASCIRW---LYEEILKVVLDkEDML 210 Caenorhabditis ...
XP_003965288 146 IQCLSKLSHSKPGLDKLfhgdlLAVLKDVMAT-S-DIVRYRIYELVVEISSVSPISLGYCAnssFISQLLGELTG-DDVL 222 torafugu
Q16401       223 VRATCIEMVTSLAY-THHGRQYLAQEGVIDQISNIIVGADSDP-FSSFYLPGFvKFFGNLAVmdSPQQICERYPIFVEKV 300 human
Q20058       210 AQLDALDTFVDIALsGKQNAEALYELGIVKKIYELMEWSKESPdGGEMYLYGT-RFMCYMAR--SYPQVLKYFPDLARRL 286 Caenorhabditis ...
Q16R63       213 LQLNVLQILSELSE-GNHGMAYLENNGVFDKLMVKIQGLGEDP-LGTILIPGLmKFYGGVAAi-HPAKVYDGYPKVIEML 289 yellow fever mo...
Q9VYG1       227 LQASVMELLVPLAE-QNHGLSYMERRRVLDIISYRVQRVEEHP-LDALLVPSImKFFGKISVy-QPLKIIGGYPHMLACL 303 fruit fly
XP_001626658 224 VQMNCLELLTKLASiSPSGLEYLDQKGVVTKLNNLLLEVETDP-LITLIIPGIiKFFGTLATa-HPLETTQQYPQFLEQT 301 starlet sea ane...
XP_002642096 211 AQLDAINIFGDIALsGKQNAEKMIEWNIVEKISELMERSRQNPdHGEMHLYGT-RFFCYLAR--SCPQVLKTFPDFVNRL 287 Caenorhabditis ...
XP_003965288 223 VRATAIEMVTTLAQ-SQHGRQYLAQQGIMDKISNMIRGAETDS-FSSLYIPGLvKFFGNLAImdSPQQVCETYPAFQNKV 300 torafugu
Q16401       301 F---EMIESQDPTMIGVAVDTVGILGSNVEGKQVL---QKTGTRFERLLMRIGHQSKNAPVELKIRCLDAISSLLYLPPE 374 human
Q20058       287 MleiRMFDQLSVVSRLGAFDHFASMCFSVEAKETLedmFKDSKDLENTLGAAGAACTMGTMELKCRTLQAVTLLFQNTTE 366 Caenorhabditis ...
Q16R63       290 F---DCLASEDMTILPTAYDTLGCIAAANEGKRQLh--YKHGAALKKTLQHFSKVIRNLPNDLKIRLLGCLRSM--FAVD 362 yellow fever mo...
Q9VYG1       304 F---MQLQSEDESILPTAMDTLANLATTPQGKILLn--MHFSGAMEKSFKKYGSHTKKLSAHIKKRLLNSLDVIYDFKTP 378 fruit fly
XP_001626658 302 Y---SMISCGDPTLMPIAMETIGVIAHSEDGLRAV---FNNQGRNKHIMKTIFGHATSSQVDLRKRALEALASIFYSEQL 375 starlet sea ane...
XP_002642096 288 MfeiRIFNDLGITDRLAAFDHFGCLCYSVEAKEMLedmFKNTNTLDSTLAAAGAAFAMGSIEMKRCTIQAITLIFENATD 367 Caenorhabditis ...
XP_003965288 301 F---EMALDPDPVMNGVALDTLGLLGSTIEGKQVL---QKTGEQFRTVLRRMSQLASSGATELRVRSLDAISQLLTLQPE 374 torafugu
Q16401       375 qqtddllRMTESWFSSLSRDPLE-LFRGISSQPFPELHCAALKVFTAIANQPWAQKLMFNSPGFVEYVVDRSVEHDKASK 453 human
Q20058       367 -------KIAETWYERLGGKALThVAVGNVKKPFPEMKNCIYDFWQQLFTYPSVVHQFITFQGFIDWALDDKSEDNPEYE 439 Caenorhabditis ...
Q16R63       363 sadnqisSITQEWYGNLAEQENLnLVMDYIKNPFPDMKRAALGLLKAIVGHRWGQTYLLNTGGFVEYLLDRKQEADKDVV 442 yellow fever mo...
Q9VYG1       379 pat-eiiNIGKNWYECFAGGAHAnIIMDLINTPFPDLQMAALSFLKTICKYNWGIVALKNTGGAVEFLLSRQKDLHRDIK 457 fruit fly
XP_001626658 376 tpseelcEFAKVLYKNMAAAPLE-AIFTVAKQPFEELRCSALCLLRSLARYQWALQDMINCPGFLEYLLDRRTEFEKSGK 454 starlet sea ane...
XP_002642096 368 -------AMASSWYGLMGDKALTqVALDNVKKPFPELKNCIYDFWQQVFKYPTLVQKFIAFPGFINWSLDEKSENAPEYE 440 Caenorhabditis ...
XP_003965288 375 qqtedllALTESWFHLLSKQPMD-MIRNISTQPFPELHCGALRIFTAIATQPWGQRLMVSTPSFMEFVLDRSTGQTKEAK 453 torafugu
Q16401       454 DAKYELVKALANSK--T----IAEIFGNPNYL-RLRTYLSegpyyvkpvSTTAVE--GAE 504 human
Q20058       440 IRKRQIIHRIIELS--EntksAEVLKADPELIgRLKKYLQ---------PAVAPAprVEE 488 Caenorhabditis elegans
Q16R63       443 LDKYEVIRVLA----------ASTVFDEQTAS-ELRRYVAegafyvqgiTEVAIE--GAS 489 yellow fever mosquito
Q9VYG1       458 YMKWQIMEILS----------ASAEFSPTETI-RFTAYVNegpyhvqadLDVATEpqGNA 506 fruit fly
XP_001626658 455 EHKYDLIKELVHFP--P----AKQIFDRPYFL-RLQEYERegpffaraeAAVAFE--GAD 505 starlet sea anemone
XP_002642096 441 MRKRQVIRRVIDLSekE----SNILNADAELIgRLKKYLqp-------sAAPAPR--IEE 487 Caenorhabditis briggsae
XP_003965288 454 DAKFELVGSLVSSS--T----AVQILGSQQYI-SLKAYLRegpyyvsavASVATE--GAE 504 torafugu
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