Conserved Protein Domain Family
Stk19

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pfam10494: Stk19 
Serine-threonine protein kinase 19
This serine-threonine protein kinase number 19 is expressed from the MHC and predominantly in the nucleus. Protein kinases are involved in signal transduction pathways and play fundamental roles in the regulation of cell functions. This is a novel Ser/Thr protein kinase, that has Mn2+-dependent protein kinase activity that phosphorylates alpha -casein at Ser/Thr residues and histone at Ser residues. It can be covalently modified by the reactive ATP analogue 5'-p-fluorosulfonylbenzoyladenosine in the absence of ATP, and this modification is prevented in the presence of 1 mM ATP, indicating that the kinase domain of is capable of binding ATP.
Statistics
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Aligned: 53 rows
Threshold Bit Score: 135.458
Threshold Setting Gi: 74856120
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EON64937      78 RDRMFSDVPErGSGMNSTRTAEVLNYRLN-LP--------PIVTVAHIHSFT-N-SPTSIDREIAELIRSGKIRKLVIPG 146 Coniosporium ap...
CCE44862     116 EEKVFQ-----IKGLSSTLKAELIRYRHS-LPq-------GLVAITQLYAIFhNeGPTFVDKSLELNIRKGILRKFIITN 182 Candida parapsi...
EDK44258     139 EEVIFQ-----IKGLSLTSKAELVKFRLS-FPs-------GIVTINQLYSIFsAqGNTFVDKQVELNVRQGLLRKFVLNN 205 Lodderomyces el...
EGV64875     121 EHLVFQ-----LKGLAMSTKAEIMKYRTThIPq-------GLVTTNQLYSIFdKeGNTFVDRNIELSIRKGQIRKFVITN 188 Yamadazyma tenu...
EEQ41705     101 QDLLFS-----LRGLSMEVKAEILKYRNHqLPr------gGMVTVNQLYTVFeHrGNTFVDRSLEKCIRDGLVMKFVITN 169 Clavispora lusi...
XP_002277335  22 esedydealsleqslTFSDTLVALRIMRAqFPqiekvsvqPFILRSQLYSSVk--DRTQVDRELESLRRDKVLRIFKLNT 99  wine grape
Q5XVE4        36 gavsedqclpledDLTFSDTSVALRMMRAqFPridqasipPFILQSQLYSSVn--DRTQVDRELECLRREKVVRVFKLNT 113 thale cress
Q0P4I9        40 aspypDFTEDpHGAVSYLCALFPRKLFNDtLP--------PLFLKHQLYSLLq--DRTAVDRLLSSLQQKGEVCLVQTGF 109 tropical clawed...
Q54WC0       133 EDILLSQIELlKAEWDYITYNK--------SP--------PLV----LQSVY-HqSNKDSERSIQILKKKGTIRLFQIAT 191 Dictyostelium d...
XP_024457353  30 etsstdqtlslvdslTFSDTMVALRIMRAqFPhidkvsiqPFILHSQLYSSVk--DRTQVDRELESLRREKVLRVFKLNT 107 black cottonwood
EON64937     147 RNAGRAagrdAVG-----------DCLVLFSDWERLV----RSHPDLTDGLK---------------------------- 183 Coniosporium ap...
CCE44862     183 ASPVISrshnKFQvnkvtygfediEVIAKVDYFHKLI----KKVMSGLDDKSssk------------------------q 234 Candida parapsi...
EDK44258     206 ASPVILrsinRLQmrkvtygyenvELLVKTEDYYKNL----INIVESTDKENeklr-----------------------l 258 Lodderomyces el...
EGV64875     189 AAPIIQtsndQARngkitygyenvEVLVKTGVFYSKI----QETLSKLTDSFqik------------------------- 239 Yamadazyma tenu...
EEQ41705     170 ASPVISrsgkSGTyhkvtygyensEVVVKKEQYLRLI----DESMGKEKPEss--------------------------- 218 Clavispora lusi...
XP_002277335 100 GQDD--------------------HAIMFMDDYLNQIerviKRMAAKKQDELav-------------------------- 133 wine grape
Q5XVE4       114 GQDD--------------------HAIIFLDDYLNQVdrivKRMEEKKQSDLei-------------------------- 147 thale cress
Q0P4I9       110 DPDT--------------------FMVVMTDDLRRTA----LSSSEGGSRATv--------------------------- 138 tropical clawed...
Q54WC0       192 SLND--------------------YCIIITTDYIKNIellkIENTTIPNKIKpetltnnmknsspiksapidtillkrse 251 Dictyostelium d...
XP_024457353 108 GQDD--------------------HAIMFLDDYLTQVdrvvKRMEEKKQRNLev-------------------------- 141 black cottonwood
EON64937     184 --EKYVTLLRATQTSSIA------SSA----L-------THSEAATLTSAGFLISTtasahsstadfflrpsvassgtls 244 Coniosporium ap...
CCE44862     235 alVKFNELISLHPTEMFIst---------ldF-------TNEEVSNLVQLGFITLTsn---------------------- 276 Candida parapsi...
EDK44258     259 tmSKFLNLAKSSPLQMFIst---------slF-------DDYEVSMLIQMGYLTLTt----------------------- 299 Lodderomyces el...
EGV64875     240 vlQKFEKFTKENPTTLFI--------StedsF-------LESELTTLVELGFITLTsn---------------------- 282 Yamadazyma tenu...
EEQ41705     219 -lVKFKEYVMSHPEALFVtt---------edF-------SVEEITKLVKLGFLTLTsn---------------------- 259 Clavispora lusi...
XP_002277335 134 -fEWFKTHVITSKLEPSIehqelcSLLs---Fgg---nvKDEHISLLINAGLLTRQ------------------------ 182 wine grape
Q5XVE4       148 -fKLFKMHVLDSKLEPSIghhellSLLs---Lgg---kvKDAHITLLINAGLLTRQ------------------------ 196 thale cress
Q0P4I9       139 -vRKFLDCDLLLSPKISYgrdevmMKHr---F-------SDGEITKLVRAGLLTVR------------------------ 183 tropical clawed...
Q54WC0       252 ilDLFIKKLIPNFNEVSItrsklfQLLs---IvnddhhqQENIITHLVQCGLLLQK------------------------ 304 Dictyostelium d...
XP_024457353 142 -fEWFKTHVIDNKQDPSIdhqelrLLLshg------gkvKDEHISLLinAGLLTRQ------------------------ 190 black cottonwood
EON64937     245 slasagsraaagtleavggvnalhnvggsgggtaisggarAAAASGAQYNFSLPNTGPYLRLLTTARSHLVTLLGKSsRY 324 Coniosporium ap...
CCE44862     277 ---------------------------------------hFNEIE-HKYSISYPGCGTYLKLVNEGRTWLVKSLNRN-KH 315 Candida parapsi...
EDK44258     300 ---------------------------------------nFSSSEEAQLEISYPGCGRFLRLINEGRMWLVGTLNRN-TH 339 Lodderomyces el...
EGV64875     283 ---------------------------------------hKNEIESQQYALSFPNCGTYLKLVNNGRSWLVKTLNKC-KF 322 Yamadazyma tenu...
EEQ41705     260 ---------------------------------------hHNEIDIHDYALAYPKCGTFLKIVNSGRAWLVRILSKM-TY 299 Clavispora lusi...
XP_002277335 183 ------------------------------------------LIDPNMYWFAIPNIGSLLKGLSQGRKELLSFLNRR-RY 219 wine grape
Q5XVE4       197 ------------------------------------------LIDPDMYWFAIPSTGKLWKGLSQGRNELLSLIKRK-RH 233 thale cress
Q0P4I9       184 --------------------------------------------DAGSWWLAVPGAGRFITHFIKGRKALLSQIRRS-RY 218 tropical clawed...
Q54WC0       305 --------------------------------------------DDCTFTFSVPGAGGFFLNLMKGRKEILSNIQRL-KY 339 Dictyostelium d...
XP_024457353 191 ------------------------------------------LIDPNMYWFAIPNIGSILKGLSQGRKELLSLVNRQ-RY 227 black cottonwood
EON64937     325 REAPVSLLRDRWDGgvadd-statqAKKvrgefvgvlpgrtkKWRTFWGLRFEWVLEEAVGMGLVEAFQTgSVGLGVRV 402 Coniosporium apo...
CCE44862     316 KEALEEELFRKWSGmnpegdpklnnFRK-----------------PFYGYDLHWVLADGLGSGIVEVFNT-PVGRGWRL 376 Candida parapsil...
EDK44258     340 KEMLEDELFRKWMGvslegdlklnnFKK-----------------PFYGYDLHWVLADAFGGGIVEVFNT-PVGRGWRL 400 Lodderomyces elo...
EGV64875     323 HELLESELFNRWEGidlndnskmsnFRK-----------------PFYGFDLNWILADALGAGIIEVFNT-PVGRGWKL 383 Yamadazyma tenui...
EEQ41705     300 KEMLEDTIYEKWEGkim------anFRR-----------------PFYGYDLTWILADSWGSGVVEPFNT-PVGRGWRL 354 Clavispora lusit...
XP_002277335 220 KEMMLAPLEKK--------------------------------RLRLSPLDMRFHLRDLIGSGHVKTVHT-PTGLVVRV 265 wine grape
Q5XVE4       234 KEMFLAELEKK--------------------------------RLRFSPLDVRFHVRDLIGSGHLKTVQT-TSGLIVRI 279 thale cress
Q0P4I9       219 KEVLLTDLSTR-------------------------------KAPPNLRLGMEFHIHDIIGAGLVDCIPT-ASGTLLRI 265 tropical clawed ...
Q54WC0       340 KEILKKDLLKK--------------------------------KLKYSNVQMQLLIKDLLGLNKIKIIPT-TQGELIRC 385 Dictyostelium di...
XP_024457353 228 KEMMLAPLEKK--------------------------------RLRLSLLDMRFHLRDLIGSGHLKTVNT-PTGLLVRV 273 black cottonwood
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