Conserved Protein Domain Family
AKAP7_NLS

?
pfam10469: AKAP7_NLS 
Click on image for an interactive view with Cn3D
AKAP7 2'5' RNA ligase-like domain
AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.
Statistics
?
PSSM-Id: 313654
View PSSM: pfam10469
Aligned: 34 rows
Threshold Bit Score: 125.839
Threshold Setting Gi: 81875160
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3J4Q_A         90 PNYFLSIPITNKK-ITAGIKVLQNSILRQDNRLTKAM-VGDGSFHITLLVMQLLNEDEVNIGTdALLELKpfv------- 160
gi 122021067   71 PTHFLSLRLPVRNvLRTRVNEMHNQILFSHQQHAPLL-VPLEKLHITLGVMAISEREETERLA-SIYDCVsev------- 141
gi 81875160   305 PTHFVALMVTESG-LRAEVVKAQEHLVRIAPSCAEFL-VPAQALHLTVVLLRLTGPGEEAAAArALRRAI---------- 372
gi 74858827    13 MNYFFGLQITELL-IYNQLKQIQNSMKKSCKYVEKDL-IPSEKFHVTVFVMEL-TDEQLSIVKsTLMPQTkll------- 82
gi 74880233    43 PNYFICIPLNDNKiIINELLNIQKFVVSKFDLLNECI-IEKEKFHISLLILYVKNKTQIDLSKeAFNEAInei------- 114
gi 260799324  482 PNYFVAIRVSNEE-IHRGLEAVQQAVLEQEKSLLPAM-IPLINMHITLLVTHL-REEQVDRAKeALRLAKape------- 551
gi 260809039  215 PNFFVAVRITDPD-ILRVAKHFRTCIFERSPVLDAALaQ-VEKLHVTLCTLRINNQDELDAARrVLRDLKres------- 285
gi 281212593   62 PNYFLGLQITEPT-ITDQLSQAQKHIANTVPLIRRDV-TAAEKFHLTVFVMTLTDVQVQLPLVkSLLQQAkli------- 132
gi 167527205  248 PNYFLCIRVWSTS-VRKQAEALQQRVLDNHPELVDCC-IPAPALHVTLPTLRLESTSDICRATqVLHNLRyvamhestff 325
gi 221057093   50 PNYFVCIPLSGNKgLVEELIKVQNHVASKFEMLKECA-IERNKFHISLLILHVKKSQMVASKe-AFREAIeei------- 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3J4Q_A        161 --------------------eeiLe---gKHL-TLPFHGIGTF-QGQVGFVKLadg---dhVSALLEIAE----TAKRTF 208
gi 122021067  142 --------------------fsvI-----HPL-QLRFRGLGTFgFGRVLFIRVvpe---adFGILETAVS----KIRRRV 188
gi 81875160   373 -----------------------LkpglqAPS-QLQFRDLVLL-GHHVLCATP--------SPTLTGMAQ----TLNQRL 415
gi 74858827    83 --------------------ateIfg-enNKP-SSSIKGIGSF-KDRVIWAGVnen--hdgYSKIVDYRN----RLYKLF 133
gi 74880233   115 --------------------------kkiNKK-NLYFKSLDTF-HNDVLYLSLne----esNDYIILLAN----IFRKCF 158
gi 260799324  552 ---------------------flRp---eNRL-VLTFQGLGTF-RNDVVFAKIqen---dhLTSLRELAE----TVQTCF 598
gi 260809039  286 --------------------arlLp----PSL-VLKFRGVETFn-NRVVYAAPe------dSPAFRALAA----RVKSLL 329
gi 281212593  133 --------------------sneIf---gENTpSSTIKGIGSFn-dRVLWSGLkdd---enSARLTEFQS----RLVKLF 181
gi 167527205  326 afvgprfisqeslcfahallrdeVgqvlpPHT-HLKLKGPALFg-SRILHLEFee----dsVAKLQQLHD----FLVDRL 395
gi 221057093  121 --------------------------kklNHQ-AISFDTLETF-RNDVLYAGLkedsrkyvVNMIALLRDaftkRDIHIF 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3J4Q_A        209 -QEKGILAGESRT---------------------------------------------FKPHLTFMKLSKAPMLWKKGVr 242
gi 122021067  189 gGELKVDMKGNPHd-------------------------------------------sYVPHVTIAKIRSKQQTQFGSKi 225
gi 81875160   416 -EAEGLRVVLLPE---------------------------------------------LQPHLTLAKVPHGTQVCLPKP- 448
gi 74858827   134 -KDQNIKVEEDRD---------------------------------------------WHPHITIAKGKNIQRNYLQIKk 167
gi 74880233   159 -EKRNIKIVYNSRkhvnnhknepnnknepnnknepnnknepnnknepnnkkeqneqnkITPHLTLMKNSHLSRIYMNRKp 237
gi 260799324  599 -VEKEVCSKKD-Kg--------------------------------------------FEPHLTLMKTSRNFGKLRSKGi 632
gi 260809039  330 -SDAGLNMAGSHEe--------------------------------------------YNPHLTLLNLSRSMCREMVSCg 364
gi 281212593  182 -EENNINIDKr-----------------------------------------------WNPHITLAKGRGGQHf------ 207
gi 167527205  396 -SSAGVSLVGTRSd--------------------------------------------YTPHITLINVKRAAARQGASVq 430
gi 221057093  173 sNHKGKEEAREKTrpsgaidkgignrtdk--------------gaavpstyqcsekeqITPHVTIMKNSYLRKIYANRKp 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
3J4Q_A        243 kie-----pglyEQFIDHRF---GEEILYQIDLCSMLKKkq-sNGYYHCESSIVI 288
gi 122021067  226 pi-------smwVEYQHHDF---GDVTFSQVDICSMRGSk---DGYYHTEGSVHL 267
gi 81875160   449 ------------EYTLNQEL---GRQPLSKLWLCRMGRA----GHSYLPLVEISL 484
gi 74858827   168 h------------mdENIEF---GFQNFSKLQLMKIGTTdp-iTKYYFVEDTIDL 206
gi 74880233   238 ki--------fpDYYSNFDLtklLTEHITPNKIQLLEMDidpkTSYYKIISEFSF 284
gi 260799324  633 kkid----pklyEEFNDQRF---GEQVVEGLQLCSMLKKke-tDGYYHTEEQVMF 679
gi 260809039  365 alssegvdpalyDQFLDRDF---GAQAVEELHLCSMGSTr--hDGFYQCAASVGL 414
gi 281212593  208 -----------vDAFNDTEF---GLQKFQSLQLLRIGSSdp-iTKYYKIEESYAL 247
gi 167527205  431 aadi----agvePLKPAAGW---GFIKANAIYLCRMTPDrt-pDGFYQVATGVPM 477
gi 221057093  239 qi--------faDYYADFNLsklQTERVVPNKIQFLEMDtdsaTSYYRVIDECGL 285
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap