5C0W,2BA1


Conserved Protein Domain Family
EXOSC1

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pfam10447: EXOSC1 
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Exosome component EXOSC1/CSL4
This family of proteins are components of the exosome 3'->5' exoribonuclease complex. The exosome mediates degradation of unstable mRNAs that contain AU-rich elements (AREs) within their 3' untranslated regions.
Statistics
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PSSM-Id: 337758
View PSSM: pfam10447
Aligned: 14 rows
Threshold Bit Score: 82.8992
Threshold Setting Gi: 74514458
Created: 29-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5C0W_I       135 LPKE--GDIVLTRVTRLSLQRANVEILAVED------KPSPIDSGIGSNGSGIVAAG-GGS--GAAtfsvsqa------- 196 Saccharomyces c...
O30033        52 IPEIvkGDVVLGRVVDLRNSIALIEVSSKKGenrgpsNRGIGILHVSNVDEGYVKEIsEAVgyLDI-------------- 117 Archaeoglobus f...
Q75E69       130 LPKE--GDVVLTRVTRITLQRANVEILAVENt------NSPIDYGVGSKGSGIVASn-----gGNTgfsmsqv------- 189 Eremothecium go...
Q6FP13       122 LPKE--GDVVLARVTRISAQKVNVEILAVENe------PIPLDSGVGSNGAGKVAP---GGgsGAStfsvsqa------- 183 [Candida] glabrata
Q59VR7       153 LPKE--NDIVLVRITKITKIQAYCEIISLDTt-----TNILPDSGLGNNGNGSHVSMsTTGsnSQHnfnqnsiassqstn 225 Candida albicans
XP_001527013 135 LPKE--NDIVLVRITRISQKQAWCEILAMENkhghfqKNILADSGLGSNGATSHASL-PAGggSQHnfniqsvasnt--- 208 Lodderomyces el...
XP_001385497 119 LPKE--NDVVLVKITKITQKQVYCEILSVEGh-----GNVLSDGGIGANGELAHDSL-PAGggSQNlsnhqtiassqata 190 Scheffersomyces...
EDK37918      90 LPKQ--GDVVLVRITRLNQKQAFCEILSVEDn-----KNVLSDSGIGAVGTTAHQSV-AVSggASAltsqaavasfqstl 161 Meyerozyma guil...
Q6BYH2       123 LPQE--GDVVLARITRLNPRQAFCEILTVEGh-----GNVLNDSGLGANGENAHRSI-PAGggSQSlsshttiasqas-l 193 Debaryomyces ha...
XP_001274632  95 LPAV--DSIVLARVTRVQKRQATVSILVV----------------LDASSSAQIPDSsKTAsdNDNiasiltsaanp--- 153 Aspergillus cla...
5C0W_I       197 ----ssdlgetFRGIIRSQDVRSTDRDRVK----------VIECFKPGDI--------VRAQVLSL 240 Saccharomyces cerevisiae S288c
O30033       118 -----------LKARVIGDNLRLSTKEEEMgvlralcsncKTEMVREGDIlkcpecgrVEKRKIST 172 Archaeoglobus fulgidus DSM 4304
Q75E69       190 ----psdlgetFRGIIRSQDVRATNRDQVK----------MVEAFRPGDI--------VRAQVLSL 233 Eremothecium gossypii
Q6FP13       184 ----ssdlgetFRGMIRSQDIRATERDRVK----------VIESYKPGDI--------IRAQILSL 227 [Candida] glabrata
Q59VR7       226 qsvqiyelgenFKGIIRINDIRLTERDKLK----------LIDCFKPGDI--------VKAQVISL 273 Candida albicans
XP_001527013 209 snaqiydigenFRGIIRSQDIRSTERDRVV----------VGECFKPGDI--------VRAQILSL 256 Lodderomyces elongisporus NRR...
XP_001385497 191 lgaqsndigenFKGIIRSQDIRSTDRDKVK----------VIDSYKPGDI--------VRALIISL 238 Scheffersomyces stipitis CBS ...
EDK37918     162 gkavaadlgetFKGIIRTQDVRLTDRDRVQ----------IVDCFRPGDI--------VRGMISSL 209 Meyerozyma guilliermondii ATC...
Q6BYH2       194 inavasdlgetFKGIIRTQDVRLTDRDRVK----------IIECFKPGDI--------VRAVIISL 241 Debaryomyces hansenii
XP_001274632 154 -enhsnsdelrFQALIRKEDVRAVEKDRVV----------MDEMFRVGDI--------VRGTVISL 200 Aspergillus clavatus NRRL 1
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