5C0W,2BA1


Conserved Protein Domain Family
EXOSC1

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pfam10447: EXOSC1 
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Exosome component EXOSC1/CSL4
This family of proteins are components of the exosome 3'->5' exoribonuclease complex. The exosome mediates degradation of unstable mRNAs that contain AU-rich elements (AREs) within their 3' untranslated regions.
Statistics
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PSSM-Id: 337758
View PSSM: pfam10447
Aligned: 14 rows
Threshold Bit Score: 82.8992
Threshold Setting Gi: 74514458
Created: 29-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5C0W_I       135 LPKE--GDIVLTRVTRLSLQRANVEILAVED------KPSPIDSGIGSNGSGIVAAG-GGS--GAAtfsvsqa------- 196
gi 74514458   52 IPEIvkGDVVLGRVVDLRNSIALIEVSSKKGenrgpsNRGIGILHVSNVDEGYVKEIsEAVgyLDI-------------- 117
gi 74695621  130 LPKE--GDVVLTRVTRITLQRANVEILAVENt------NSPIDYGVGSKGSGIVASn-----gGNTgfsmsqv------- 189
gi 74609263  122 LPKE--GDVVLARVTRISAQKVNVEILAVENe------PIPLDSGVGSNGAGKVAP---GGgsGAStfsvsqa------- 183
gi 74589594  153 LPKE--NDIVLVRITKITKIQAYCEIISLDTt-----TNILPDSGLGNNGNGSHVSMsTTGsnSQHnfnqnsiassqstn 225
gi 149244958 135 LPKE--NDIVLVRITRISQKQAWCEILAMENkhghfqKNILADSGLGSNGATSHASL-PAGggSQHnfniqsvasnt--- 208
gi 126137948 119 LPKE--NDVVLVKITKITQKQVYCEILSVEGh-----GNVLSDGGIGANGELAHDSL-PAGggSQNlsnhqtiassqata 190
gi 190345945  90 LPKQ--GDVVLVRITRLNQKQAFCEILSVEDn-----KNVLSDSGIGAVGTTAHQSV-AVSggASAltsqaavasfqstl 161
gi 74603903  123 LPQE--GDVVLARITRLNPRQAFCEILTVEGh-----GNVLNDSGLGANGENAHRSI-PAGggSQSlsshttiasqas-l 193
gi 121714042  95 LPAV--DSIVLARVTRVQKRQATVSILVV----------------LDASSSAQIPDSsKTAsdNDNiasiltsaanp--- 153
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
5C0W_I       197 ----ssdlgetFRGIIRSQDVRSTDRDRVK----------VIECFKPGDI--------VRAQVLSL 240
gi 74514458  118 -----------LKARVIGDNLRLSTKEEEMgvlralcsncKTEMVREGDIlkcpecgrVEKRKIST 172
gi 74695621  190 ----psdlgetFRGIIRSQDVRATNRDQVK----------MVEAFRPGDI--------VRAQVLSL 233
gi 74609263  184 ----ssdlgetFRGMIRSQDIRATERDRVK----------VIESYKPGDI--------IRAQILSL 227
gi 74589594  226 qsvqiyelgenFKGIIRINDIRLTERDKLK----------LIDCFKPGDI--------VKAQVISL 273
gi 149244958 209 snaqiydigenFRGIIRSQDIRSTERDRVV----------VGECFKPGDI--------VRAQILSL 256
gi 126137948 191 lgaqsndigenFKGIIRSQDIRSTDRDKVK----------VIDSYKPGDI--------VRALIISL 238
gi 190345945 162 gkavaadlgetFKGIIRTQDVRLTDRDRVQ----------IVDCFRPGDI--------VRGMISSL 209
gi 74603903  194 inavasdlgetFKGIIRTQDVRLTDRDRVK----------IIECFKPGDI--------VRAVIISL 241
gi 121714042 154 -enhsnsdelrFQALIRKEDVRAVEKDRVV----------MDEMFRVGDI--------VRGTVISL 200
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