5C0W,2BA1


Conserved Protein Domain Family
EXOSC1

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pfam10447: EXOSC1 
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Exosome component EXOSC1/CSL4
This family of proteins are components of the exosome 3'->5' exoribonuclease complex. The exosome mediates degradation of unstable mRNAs that contain AU-rich elements (AREs) within their 3' untranslated regions.
Statistics
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Aligned: 13 rows
Threshold Bit Score: 84.8214
Threshold Setting Gi: 74514458
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5C0W_I       135 LPKE--GDIVLTRVTRLSLQRANVEILAVEDk------PSP-----IDSGIGSNGSGIVAAg-gGS--GAATFSVSQA-- 196 Saccharomyces c...
EDO15415     122 LPKE--GDIVLAKVTRISLQRANLEILAVENq------PVP-----IDSGVGSNGHGVVAA---GGgsGSSKFSVAQT-- 183 Vanderwaltozyma...
Q6FP13       122 LPKE--GDVVLARVTRISAQKVNVEILAVENe------PIP-----LDSGVGSNGAGKVAP---GGgsGASTFSVSQA-- 183 [Candida] glabrata
P53859       132 LPKE--GDIVLTRVTRLSLQRANVEILAVEDk------PSP-----IDSGIGSNGSGIVAA---GGgsGAATFSVSQA-- 193 Saccharomyces c...
Q75E69       130 LPKE--GDVVLTRVTRITLQRANVEILAVENt------NSP-----IDYGVGSKGSGIVASn-----gGNTGFSMSQV-- 189 Eremothecium go...
O30033        52 IPEIvkGDVVLGRVVDLRNSIALIEVSSKKGenrgpsnRGI-----GILHVSNVDEGYVKEiseAVgyLDI--------- 117 Archaeoglobus f...
EDN05906     135 LPTV--DSVVLARVTRVQKRQATLSILVV---------------------LDDNPSSPYPAttaAAdgLPHSLLSTTNad 191 Histoplasma cap...
EAW13206      95 LPAV--DSIVLARVTRVQKRQATVSILVV---------------------LDASSSAQIPDsskTAsdNDNIASILTSaa 151 Aspergillus cla...
ABN67468     119 LPKE--NDVVLVKITKITQKQVYCEILSVEGh-----gNVL-----SDGGIGANGELAHDSl-pAGggSQNLSNHQTIas 185 Scheffersomyces...
XP_001486345  90 LPKQ--GDVVLVRITRLNQKQAFCEILSVEDn-----kNVL-----LDSGIGAVGTTAHQSv-aVSggASALTSQAAVas 156 Meyerozyma guil...
Q6BYH2       123 LPQE--GDVVLARITRLNPRQAFCEILTVEGh-----gNVL-----NDSGLGANGENAHRSi-pAGggSQSLSSHTTIas 189 Debaryomyces ha...
EDK43663     135 LPKE--NDIVLVRITRISQKQAWCEILAMENkhghfqkNIL-----ADSGLGSNGATSHASl-pAGggSQHNFNIQSVas 206 Lodderomyces el...
2BA1_A        52 IPEIvkGDVVLGRVVDLRNSIALIEVSSKKGe-----nRGPsnrgiGILHVSNVDEGYVKEiseAVgyLDI--------- 117 Archaeoglobus f...
5C0W_I       197 ---------SSDLGETFRGIIRSQDVRSTDRDRVK----------VIECFKPGDI--------VRAQVLSL 240 Saccharomyces cerevisiae...
EDO15415     184 ---------SSDFGEPFRGILRSQDVRATERDRVK----------LIENFKPGDI--------IRAQVLSL 227 Vanderwaltozyma polyspor...
Q6FP13       184 ---------SSDLGETFRGMIRSQDIRATERDRVK----------VIESYKPGDI--------IRAQILSL 227 [Candida] glabrata
P53859       194 ---------SSDLGETFRGIIRSQDVRSTDRDRVK----------VIECFKPGDI--------VRAQVLSL 237 Saccharomyces cerevisiae...
Q75E69       190 ---------PSDLGETFRGIIRSQDVRATNRDQVK----------MVEAFRPGDI--------VRAQVLSL 233 Eremothecium gossypii
O30033       118 ----------------LKARVIGDNLRLSTKEEEMgvlralcsncKTEMVREGDIlkcpecgrVEKRKIST 172 Archaeoglobus fulgidus D...
EDN05906     192 --------pLNADDLRFQALIRKEDVRAVEKDRVV----------MDEMFRVGDI--------VRAVVISL 236 Histoplasma capsulatum NAm1
EAW13206     152 np----enhSNSDELRFQALIRKEDVRAVEKDRVV----------MDEMFRVGDI--------VRGTVISL 200 Aspergillus clavatus NRRL 1
ABN67468     186 sqatalgaqSNDIGENFKGIIRSQDIRSTDRDKVK----------VIDSYKPGDI--------VRALIISL 238 Scheffersomyces stipitis...
XP_001486345 157 fqstlgkavAADLGETFKGIIRTQDVRLTDRDRVQ----------IVDCFRPGDI--------VRGMISSL 209 Meyerozyma guilliermondi...
Q6BYH2       190 qas-linavASDLGETFKGIIRTQDVRLTDRDRVK----------IIECFKPGDI--------VRAVIISL 241 Debaryomyces hansenii
EDK43663     207 nt---snaqIYDIGENFRGIIRSQDIRSTERDRVV----------VGECFKPGDI--------VRAQILSL 256 Lodderomyces elongisporu...
2BA1_A       118 ----------------LKARVIGDNLRLSTKEEEMgvlralcsncKTEMVREGDIlkcpecgrVEKRKIST 172 Archaeoglobus fulgidus D...
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