5BUG,3V0J,3N0A


Conserved Protein Domain Family
PTEN_C2

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pfam10409: PTEN_C2 
Click on image for an interactive view with Cn3D
C2 domain of PTEN tumor-suppressor protein
This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (pfam00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane.
Statistics
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PSSM-Id: 337738
View PSSM: pfam10409
Aligned: 50 rows
Threshold Bit Score: 33.0148
Threshold Setting Gi: 268554025
Created: 22-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5BUG_A       177 PVALLFHKMMFETIPm-fSGG--TcnPQFVVCQLKVKI-------YSSNSGPTRRED-KFMYFEFPQPLPV-CGDIKVEF 244 human
Q9Y0B6       198 KVSLNVCEIRFSESScvqNLGmvEcsISVLHDSATENAk------PDRLKTLPIDFQ-KSFVLTIKPSIPV-SGDVKFEL 269 fruit fly
Q6TGR7       192 PVALLFHKMVFQTLPm-fSGG--TcnPQFVVYQLKVKI-------HTSNPAHTRREE-KHMIFEFPQPLPV-CGDIKVEF 259 zebrafish
XP_017213426 109 RKSLKIKSIRIHSIAgvgKGN--GsdLKLKIIVKHELVfqcvcakQHNCTVFPDTGS-NAVVISLQDGPIV-TGDVKVMF 184 zebrafish
NP_001116943 189 PVPLLFHKIEFETIPm-fSGS--TcnPQFVVYQLKVKIft--------sTAGPKRIE-KLMYFDFPQPLPV-CGDIKVEF 255 western clawed ...
AAI21584     240 EKQLKIRSIRIYSIQgvgRSN--GtdLKVQIIMKKEVVfqcvcetQGNCKLFFDAGN-NSIVISLDGCPVI-SGDIKIRF 315 western clawed ...
3V0J_A       194 MKKLKVTGVTITAIQgvgRGN--GsdLSMQIVSERQEVllc--kfAEGYNCALQYDAtDDCVTCEVKNCPVlAGDIKVRF 269 vase tunicate
XP_003964007 190 PVALLFHKMVFETLPm-fSGG--TcnPQFVVYQLKVKI-------HTSNPSHTRRED-KHMFFEFPQPLPV-CGDIKVEF 257 torafugu
CAF94889     190 PVALLFHKMMFETIPm-fTGG--TcnPQFVVYQLKVKI-------YTSSPSLIRRED-KLMVFEFPQPLPV-CGDIKVEF 257 spotted green p...
XP_001328232 201 RKLKTITFQNMYTKPk---------nIYITIQNSEWDVi------YNSAWVLDPTDK-ASKEFSYDLGVNI-KGDFIMNV 263 Trichomonas vag...
5BUG_A       245 -FH--KQNk--MLKKDKMFHFWVNTFFIPgpeed---------------------------------------------- 273 human
Q9Y0B6       270 -TK--KS------PDKIICHFWLNTFFVRnyspce--------------------------------------------- 295 fruit fly
Q6TGR7       260 -FH--KQSk--MMKKDKMFHFWINTFFIPgpeeagdkvengsvvndvdslscqsqsspaerdrekeravaaaaldrerge 334 zebrafish
XP_017213426 185 eSS--AGLp--KGYEDCPFYFWFNTSFVE--------------------------------------------------- 209 zebrafish
NP_001116943 256 -FH--KQNk--VMKKEKMFHFWINTFFIPgpeeysekvengtlvge-------------------------qeldgiyst 305 western clawed ...
AAI21584     316 eSS--ANIp--KGYDDCAFYFWFNTSFIE--------------------------------------------------- 340 western clawed ...
3V0J_A       270 -MStsKSLp--RGYDNCPFYFWFNTSLVE--------------------------------------------------- 295 vase tunicate
XP_003964007 258 -FH--KQNk--MMKKDKMFHFWVNTFFIPgpeesrdklengavnnadsqq-----------------gvpapgqgqpqsa 315 torafugu
CAF94889     258 -FH--KQNk--MMKKEKMFHFWVNTFFIPapeenfsklengssstlr------------------------dlqqlgllv 308 spotted green p...
XP_001328232 264 -YE--VKKglvSSSAKCKLYFTMTTLFIH--------------------------------------------------- 289 Trichomonas vag...
5BUG_A       274 ----ndkeYLVLTLTKNDLDKANKDkanRYFSPNFKVKLYF 310 human
Q9Y0B6       296 --sdgtvnKYIHTLSKSEIDDVHKDsehKRFSEEFKISIVF 334 fruit fly
Q6TGR7       335 qradgekdYLILTLTKNDLDKANKDkanRYFSPNFKVKLYF 375 zebrafish
XP_017213426 210 --------NYRLFLSREELDNPHKPktwDIYKEDFGVTLSF 242 zebrafish
NP_001116943 306 ersdndkeYLTLTLTKNDLDKANKDkanRLFSPNFKVKLFF 346 western clawed frog
AAI21584     341 --------NSRLYLSKNELDNPHKEksgKIYKENFAVELNF 373 western clawed frog
3V0J_A       296 --------GDHVTLKREEIDNPHKKktwKIYRDNFTVKLTF 328 vase tunicate
XP_003964007 316 ecresdrdYLILTLSKNDLDKANKDkanRYFSPNFKVKLYF 356 torafugu
CAF94889     309 gldgserdQLVLTLTKNDLDKANKDkanRNFSPNFKVKLFF 349 spotted green pufferfish
XP_001328232 290 --------DDTIIVPRNLIDGTDKDknfEKYTPDFQVIFEF 322 Trichomonas vaginalis G3
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