3GEH,1XZP,3GEE


Conserved Protein Domain Family
TrmE_N

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pfam10396: TrmE_N 
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GTP-binding protein TrmE N-terminus
This family represents the shorter, B, chain of the homo-dimeric structure which is a guanine nucleotide-binding protein that binds and hydrolyzes GTP. TrmE is homologous to the tetrahydrofolate-binding domain of N,N-dimethylglycine oxidase and indeed binds formyl-tetrahydrofolate. TrmE actively participates in the formylation reaction of uridine and regulates the ensuing hydrogenation reaction of a Schiff's base intermediate. This B chain is the N-terminal portion of the protein consisting of five beta-strands and three alpha helices and is necessary for mediating dimer formation within the protein.
Statistics
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Aligned: 1034 rows
Threshold Bit Score: 63.5121
Threshold Setting Gi: 283440507
Created: 28-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3GEH_A              9 TIAAIATAivPQ-Q--GSVGIVRVSG-----------------SQ-AIaiaQTLfdaPGkq--vWESHRILYGYI----R 61  Nostoc sp....
eebua:ZICARI_002    7 sIIALSTP--NG-I--GGIGIIRISG-----------------NK-IFnilEKLc--NKkv-knLKPRHSYYTY-----F 55  Candidatus...
O67030              4 PIVAIATP--YG-E--SAIGIVRLSG-----------------KG-VLdlvKKFf--KTkr--eIKPRYAHFGVL----Y 52  Aquifex ae...
BAI70283            7 PIIAIATP--YG-E--SAIGMIRISG-----------------LG-VLekvKKYv--RTkg--eIKPRYAHFFAL----L 55  Hydrogenob...
jgi:Thal_0306       7 PIVALATP--YG-E--SAIGVLRLSG-----------------KG-VLekiKPFl--KLkg--aVKPRYAHLVTL----V 55  Thermocrin...
CBW28188            9 PIIACST----GlQsnSAIGLIRISGfsdlsifqdffkidlanVK-ARyshf--------------------------ts 57  Halobacter...
jgi:HY04AAS1_0680   4 TIVAPATP--VL-K--SAISILRLSG-----------------FN-CIdiaNRFl--HIe---nPKPRYAYRTSF----Y 51  Hydrogenob...
jgi:Kole_2156       5 PICAIATS--PG-I--SALGIIRCSG-----------------EG-SWeklLPFv--NVt---dPKPWRLYLTPF----- 51  Kosmotoga ...
ACI16789            3 PIVALATP--WG-V--GALHVIRISG------------------DaSK---NTVe--AFldkplQKPRHASLRYF----S 50  Coprotherm...
INMI:Cabys_4216    10 TIIAPISG--LS-G--GSVHLIRISG-----------------TK-AVeitSRFf--SNsrfsrAEKNRFFYGQlvneqN 64  Caldithrix...
3GEH_A             62 -HPqTRqIVDEALLLLMKAPRSYTREDVVEFHCHGGIIAVQ----QVLQ-LClESg----ARLAQPGEFTLRAFLNGR 129 Nostoc sp. P...
eebua:ZICARI_002   56 --KnKEeILDYGILIYYNSPFSYTGENIIEIQCHSNPIIIN----KIIN-TClflgsnsklKIAKRGEFTKRAFLNKK 126 Candidatus Z...
O67030             53 -DD-KGeELDEGVLIYYKAPHSYTGEDMVELNLHGNPRILK----RALE-LFvNAg----ARLAEPGEFTKRAFLNGK 119 Aquifex aeol...
BAI70283           56 -DE-DGqVLDEGVLIYYKSPASYTGEDMIEMCLHGNPLILK----RALE-LFlKEg----IRLAEPGEFTKRAFLNGK 122 Hydrogenobac...
jgi:Thal_0306      56 -DE-EGrEIDEGILVFYPSPKSYTGEDMIELSLHGNPLILH----RALE-LFlSAg----IRLAEPGEFTRRAFLNGK 122 Thermocrinis...
CBW28188           58 iiD-GDiTLDEIVLTFYSAPNSYNGENILELGVHGNQINIQriisLFINsKL--------VRAAKEGEFSYRALKNKK 126 Halobacterio...
jgi:HY04AAS1_0680  52 --V-NNkELDDVIAIYYKAPRSYTGEDMLEIFFHGNPIIIE----KAIE-TLvDYg----CSFASPGEFTKRAFLNGK 117 Hydrogenobac...
jgi:Kole_2156      52 --TiNGeMIDEVMIAFYKSPKSYTGEDMVELISHGSPLILR----IILQ-ELiKVg----FRQALPGEFTKRAVLNGK 118 Kosmotoga ol...
ACI16789           51 sEk----VEDQVVAIWYSEPHSYTGEEMVEIMCHGNPAIAE----LIIE-TLlDAg----MKPAQPGEFTFRAFLNGK 115 Coprothermob...
INMI:Cabys_4216    65 e------PLDDVIVLLYRKPHSYTGEDVVEISCHGNILITE----QIIE-LYlRq----gCRLAQPGEFTKRAFMNGR 127 Caldithrix a...
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