1BOB


Conserved Protein Domain Family
Hat1_N

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pfam10394: Hat1_N 
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Histone acetyl transferase HAT1 N-terminus
This domain is the N-terminal half of the structure of histone acetyl transferase HAT1. It is often found in association with the C-terminal part of the GNAT Acetyltransf_1 (pfam00583) domain. It seems to be motifs C and D of the structure. Histone acetyltransferases (HATs) catalyze the transfer of an acetyl group from acetyl-CoA to the lysine E-amino groups on the N-terminal tails of histones. HATs are involved in transcription since histones tend to be hyper-acetylated in actively transcribed regions of chromatin, whereas in transcriptionally silent regions histones are hypo-acetylated.
Statistics
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PSSM-Id: 337730
View PSSM: pfam10394
Aligned: 177 rows
Threshold Bit Score: 77.1948
Threshold Setting Gi: 74778847
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1BOB_A        11 WTSSANEALRVSI-----VGENa---------vQFSPLFTYPIYGDSEKIYGYKDLIIHLAFDSVTFKPYVNVKYSAKL- 75
gi 301122169  27 nTASSNEVTSLAI-----Veaq--------kleWFSPKFTYHAFGADEAVDGYEGLKMMVTFNGFDFRALLDVKFKEKEd 93
gi 297796559  28 tGVEANECIKIYL-----VSSKeevds--pdisCVKPVDLNDFFDGDGKIYGYQGLKINVWINSISLHSYADITYQSTt- 99
gi 168048048  32 nfCNADEAITLHL-----VKTEkdylqggnedlSFPPEFTEQFFGEEGRIYGYTGLKVEVFIHTVSFYTHYHLTFDSIAk 106
gi 225444999  27 tGVEAKDCIKIFL-----VSRKdevga--sdsfCIDPVDLNSFFEEDGKIYGYQGLKITVWINSISFHSYANITFQSTSd 99
gi 552830286  16 tglpAEEALTFHL-----LKKDaegrvvieengNFPPEMTHQLFGEKEEIVGYDGLSIDVWLTPQ-FQAFIDVKYAAKgp 89
gi 695056486  27 tGVEASECIKVFL-----VKSGdevgs--tnsfCINPVDLNQFFGEDGKIYGYKGLRVNIWLSTVSFHAYSEITFESTSd 99
gi 356501087  28 SGVEAKDCITIYL-----VSSKeefda--pesfVIHPVDLNSFFDDDGKIYGYEGLKITIWISSISFYAYADITFQSssd 100
gi 565405121  28 AGIEANDCITIYI-----VSSAedvds--pssfCLEPIDLNQFFEDDGRIFGYQGLKITIWVSLISFHAYADISFESssd 100
gi 145345021  69 YVCEAVDALKFHPwtpgsALETtrdd-----gdaFDAEFTHQVFREDESVFGYAGLALDVYVCRTSLRALLKMRYEKKIs 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1BOB_A        76 --Gddn-ivDVEKKLLSFLPKDdvI----VRDEAKWVDCFA-EERkTHN-LsdV----FEKVSEYS-------------L 129
gi 301122169  94 taG------DVVAKLTSSLPKG--F----VQDKGEFVGALR-KAAtDFTgP--P----GKCIESYC-------------L 141
gi 297796559 100 -nGdkg-itDLKSALQNIFAET--I----VDNKDEFLQTFStQSDfIRN-M--Vs--nGEVMRSGA-------------T 153
gi 168048048 107 dgGarnpktNLRAKLKEIFGES--L----IDNRDAFIEKIK-QSTdSFV-Q--VikeeGTAVDSWRaptgrnpsdvsrmA 176
gi 225444999 100 --Ggkg-itDLKSALQTIFAET--L----VETKDDFLQTFStERHyIRS-M--Vs--nGEILQHKA-------------S 152
gi 552830286  90 g------atELKQPFADAFEAG--F----FQDKAQFDAALQ-EEAgIDVgL--L----GEQVASRE-------------T 137
gi 695056486 100 --Ggkg-itDLEPALQDIFGE---L----LTEKEQFLQTFStERNfIRN-I--Vs--dGAVVPCKT-------------S 151
gi 356501087 101 rg---kgvtDLKSALQTIFAET--L----VDSKDEFLQKYLaDNDfVRT-N--Is--nGETLKHKA-------------F 153
gi 565405121 101 gg---rgitNVKYALQNIFAES--L----VDEKDAFLQTFStESHyVRS-V--Vs--nAETLQHKV-------------S 153
gi 145345021 144 saMnp--adPVVEQMREWFDSD--GlcelYEDEERF----K-REAgMAE-P--Ca--gGTLVAESE-------------S 196
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
1BOB_A       130 ----------NGe---------E-------------FVVYKSSL--VD-DFARrMHRRVQIFSLLFIE 162
gi 301122169 142 ksqi--edfaEEr---------H-------------FEIYECKL--EDnEPAQkLLANLQTLSLWFIE 183
gi 297796559 154 ----------DGssnnaevvpsD-------------LQVIRMEI--GS-PNAGlLYSRLVPLVLLFVD 195
gi 168048048 177 ----------NGk---------L-------------RQVVRLEL--TD-PRVRkWYTCLTPLIHLFVE 209
gi 225444999 153 ighssnsgraEDs---------D-------------LEVIRMVM--GN-MAAGhLYSRLIPLVLLLVD 195
gi 552830286 138 e---------EGs---------T-------------FRVCHAHLatAN-PALKaMHARLQPLLYFFVD 173
gi 695056486 152 ----------KEd---------DhasnsnseadgsmIEVIRMKQ--DS-EPVClLYSRlvplvlllvd 197
gi 356501087 154 ----------KEnicds-nqltDsst--------stVEVVRLVA--GN-MATGqLYSHLIPLTLLLVD 199
gi 565405121 154 ----------NGcstes-ncllKsep--------sdVEVFR--I--AG-TPVGhLYSRLVPLVLLLVD 197
gi 145345021 197 ----------DGvv--------------------tkITAYELAT--NE-EARk-WHAAMEAYAVFFID 230
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