5VZD,3MDA,1JMS,4P4M


Conserved Protein Domain Family
DNA_pol_lambd_f

?
pfam10391: DNA_pol_lambd_f 
Fingers domain of DNA polymerase lambda
DNA polymerases catalyze the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the central three-helical region of DNA polymerase lambda referred to as the F and G helices of the fingers domain. Contacts with DNA involve this conserved helix-hairpin-helix motif in the fingers region which interacts with the primer strand. This motif is common to several DNA binding proteins and confers a sequence-independent interaction with the DNA backbone.
Statistics
?
PSSM-Id: 402146
View PSSM: pfam10391
Aligned: 192 rows
Threshold Bit Score: 52.7996
Threshold Setting Gi: 81990391
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5VZD_A       110 KLFTQIFGVGVKTADRWYRE-GLRTLDDLRE-------------QpQKLTQQQK--AGLQHHQDLS 159
XP_003644393 239 EYFVQCHEVGPTTASQWQAL-HYKSFKDVLT-------------HtKQWNLHWSilYGMRFFEEWQ 290 Eremothecium cymbalariae DBVP...
Q757Q1       219 RYFAACHDVGPGRAQQWRAL-GFESFADVLR-------------AsPQWRLPWAmlYGMRFYEDWQ 270 Eremothecium gossypii
EDO19161     299 QYFSTCHGVGSETAKRWNSL-KLDSFKDVLEk------------FpNEFAVEWPilFGWSYYEDWQ 351 Vanderwaltozyma polyspora DSM...
CCK73483     272 DYFSNCHGVGAYTAKRWHLF-KLNSLTDVVKk------------FpDELTKDWPilLGWSYYEDWS 324 Naumovozyma dairenensis CBS 421
XP_002556450 263 EYFMNCYGVGSHTARKWADG-GARTFKDALKl------------FpSDFS--WSilFGWKYYDDWT 313 Lachancea thermotolerans CBS ...
EKC19924     185 KIFTKVFGAGTKTAQEWIEK-GWTTVDEVRQ---------------NYTKGDWRlrFGLAFHEELm 234 Pacific oyster
A0D335       365 gQLSRVWGIGPTTAATFYFK-GIRTLEDLRK-------------NkHLLNRNQQ--VGLHLVEDLE 414 Paramecium tetraurelia
Q7T6Y4       104 QELENVIGIGSSTAKKLISQyGIRSVDDLKKa-----------iEtGKVKVSTSimLGLKYYGIVQ 158 Acanthamoeba polyphaga mimivirus
CBN80507     286 QQLMKVHGVGSRTAKDWYNR-GIRSVEDARRtllpndddtegdeKrPNLKPEVV--MGLKHFHDMQ 348 Ectocarpus siliculosus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap