4LZD,3K75,3MGH,4QZC,4P4M


Conserved Protein Domain Family
DNA_pol_lambd_f

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pfam10391: DNA_pol_lambd_f 
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Fingers domain of DNA polymerase lambda
DNA polymerases catalyze the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the central three-helical region of DNA polymerase lambda referred to as the F and G helices of the fingers domain. Contacts with DNA involve this conserved helix-hairpin-helix motif in the fingers region which interacts with the primer strand. This motif is common to several DNA binding proteins and confers a sequence-independent interaction with the DNA backbone.
Statistics
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PSSM-Id: 337729
View PSSM: pfam10391
Aligned: 216 rows
Threshold Bit Score: 50.0769
Threshold Setting Gi: 170090083
Created: 28-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
4LZD_A        112 KLFTQIFGVGVKTADRWYREGLRTLDDL--R--E--QpQKLTQQQKAGLQHHQDLS 161
gi 299740693  658 aLFQGIYGVGRSTAYKWYNAGCRTLDDI--R--QgkGgVKLSAVQEIGLKYYDDIN 709
gi 630199247  690 KLFQGIYGVGQSTAVKWYQNGCRTLDDL--RkgK--GgVRLSKAQKIGLQYYDDIN 741
gi 599388424  883 RLFQGIYGVGSITSLKWYAAGCRTLDDIhqR--K--GgIKLSDAQELGLKYYDDIN 934
gi 527299242  565 sLFQGIYGVGRHTAFKWYNSGCRTLDDIfaR--K--GgIKLSACQEIGLKHYADIN 616
gi 449544000  450 tLFQGIYGVGLNTARKWYNRGCRTLQDL--NegK--GgVQLSHVQQIGVNYYADIN 501
gi 170097211  705 RLFQGIYGVGRSTAFKWYAAGCRTLDDI--SagK--FgVSLSRAQEIGIRFYDgan 756
gi 471900469  431 RLFQGVYGVGPQTAHSWYVRGLRTLTDI--R--NrmDgIVLSPAQELGLQYYTDLQ 482
gi 954205257  221 KLFNTVWGVGPRTAEKWYLQGLRTIEDV--Q--R--NvA-LTGQEHIGFKYREEIL 269
gi 597937250  269 tIFQGIYGVGRQIALMWYANGCRTLDDIkaR--K--GgIKVSSVQDIGIQFYDDIN 320
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