Conserved Protein Domain Family
Mei5

?
pfam10376: Mei5 
Double-strand recombination repair protein
Mei5 is one of a pair of meiosis-specific proteins which facilitate the loading of Dmc1 on to Rad51 on DNA at double-strand breaks during recombination. Recombination is carried out by a large protein complex based around the two RecA homologs, Rad51 and Dmc1. This complex may play both a catalytic and a structural role in the interaction between homologous chromosomes during meiosis. Mei5 is seen to contain a coiled-coli region.
Statistics
?
PSSM-Id: 313578
View PSSM: pfam10376
Aligned: 14 rows
Threshold Bit Score: 141.455
Threshold Setting Gi: 156839385
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311033362   25 PSTPQasA----------NPSSPYTNSSRKQPMSATLRERLRKTRFSFNSSYNVVKRLKVE--SEENDQTFSEKPASSTE 92
gi 21264167    71 ALTPDlrDtkihtslpitTPFSKKRAREAKNILLKPFKSPLRQTASPQVADTNLKPSLAVTnlNSDETNTSSEPVTSPLR 150
gi 2507061     15 VNEEEntC----------INHSYTKKDTNNYRVGKSGIKDLKKPTNQ--------KEIAIK-----NRELTKQLTLLRQE 71
gi 367009212   23 ICSPTktP----------VESVSKYKTAGKHLVQKS-RETLEDHKLN--------TQTRLL-----YNELSKQKNLYKKH 78
gi 327267548   13 CSTPEtsD----------QKSCS---SSEKQPMSSTLRERLKKARRSFHSTLIVPKRLKID--EENNCSSTCKEESLPKG 77
gi 611967158   12 PATPKasE----------TVAVSQSHSSGKQLMSATLRERLKKTRSSFNSCYALAKRVKGD--TEENNSTVSKRATSSSD 79
gi 1040197350  31 PSTPQacA----------NPPSSLARSSGKQPMSATLRERLRKTRVSFNSCYSVVKRLKVD--NEENDQNLSEKPPSATE 98
gi 514470931   12 PSTPQacA----------NPPSLHTDSSGKAPMSATLRDRLRKTRFSFNSCCSVVKRLKTE--NEENDHIFSEKPESSTE 79
gi 731466913   11 PSTPQacE----------IPSSPCTYSSGKQPMSATLRERLRKTRSSFNSCSSVVKRLKVE--NEESDPIFSEKPVSSME 78
gi 972972051   13 FCTPD--S----------TLNSTPHGLSVKQPMSASLKERLKRTRRSFHSPFTVAKRLKIDppEAEDDSKVQEVSPKSER 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311033362   93 ENCLEFQESFKHIDSEFEENTNL---KNTlknlnvCESQ----SLdsgscSALQNEFVSEKLpk---------qRLNAEK 156
gi 21264167   151 TT----PNSIK------RQKRLF---KSPisnclnPKSDpe-------------------------------itQLLSRR 186
gi 2507061     72 NNHL--QQACKILS----ENKIIenrKSIekwrtiCEME-----------LSFILNSTLIKInrmggykdflekEMEAKK 134
gi 367009212   79 IDNL--AQAIKIIKAGEKESRVL---ELIekwrgvAQAG-----------MSFMLNSAMLKItklggyeellkkELEAER 142
gi 327267548   78 ESYCISQSKDEDLEKVPDETSHL---KSTiqerdlCMSEctgySKnaqgsTEVLLLGKDDRLw-----------ELMEEK 143
gi 611967158   80 GSCSGSSENCKNMEKA-EESLCL---KDPlkdvdvYRSE------------SLELSGLPDNLpvvseghsigkkELLEEK 143
gi 1040197350  99 ENCLEFQESFKRIDSELEESTHL---KNTfqnvsaCEAT----SLdtgscSVLQNDFMKENLpi---------qGLKEER 162
gi 514470931   80 KDCLKFQESCEHIDSEPEEHTYL---KNTlqn--tsESK----SLdtgsyGVLQNDFVNENFk----------qGLKEEK 140
gi 731466913   79 ENHLEFQGSFKHTDSESEKSTYL---KNTfknisaCESK----SLdtgscSALQNDFASENLpk---------qELKEEK 142
gi 972972051   81 DLDSAGGNTVSINKGRPWESPEV---TDTsrqwdvCRTGtesgNEaaqssSSRERADPPAQI------------DLLQLR 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311033362  157 AKLVKQVQE----------KEDLLRRLKLVKMYRSKNDLSQLQLLIKKWRSCSQLLLYELQSAVS--------------- 211
gi 21264167   187 LKLEKEVRN----------LQEQLITAETARKVEAKNEDKDLQTLIQKWKNAAQQAAEVLFKPMAerirlaggvtqsfri 256
gi 2507061    135 RRLEYQIDNgmedqiceikESDDFRQLSEVEKQEWESQMNE---QLKELEKKKIAELEKLNKVLH--------------- 196
gi 367009212  143 RKLDYQINDnlqddmeqvfESEEFLALPEEMQQEYRDQMNE---QLREVQNRKDKEIAKLEAKMK--------------- 204
gi 327267548  144 ATLVKQVQE----------KEELLRRLKLVKMYRSKNNPTELQSLISKWRSSSQMMLYELQMALA--------------- 198
gi 611967158  144 MKLLKQVQE----------KEELLRRLKLTKMYRSKNDLSHLQSLIKKWRNSSQLLLFELQSTLS--------------- 198
gi 1040197350 163 AKLVKQVQE----------KEDLLRRLKLVKMYRSKNDLSQLQSLIKKWRNCSQLLLHELHSAMS--------------- 217
gi 514470931  141 AKLVKQVEE----------KEDLLRRLKLVKMYRSKNDLSQLQLLIKKWRSCSQLLLYELQSAMS--------------- 195
gi 731466913  143 AKLVKQVQE----------KEDFLRRLKLVKMYRSKNDLSQLQLLIKKWRNCSQQLLYELQSAMS--------------- 197
gi 972972051  146 DRLKKEVGE----------KEEMLRRLKMVRMYRTKNDLDKLQFLINKWRGSSQAVLYELKSAFC--------------- 200
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 311033362  212 -E-ENK--------KLSLTQLIDHYGLDDKLLHYN 236
gi 21264167   257 eEgENKgqiqevrtEFTMSMFLNQFGVPVHLMSFD 291
gi 2507061    197 -DsEGK--------DFGMAELCTRLKLDYSLIFPQ 222
gi 367009212  205 -EsAGQ--------EMTMQELSRRIKMDYMLIFPe 230
gi 327267548  199 -T-DNQ--------KLSITQLIDNFGLDDQLLHYN 223
gi 611967158  199 -V-ENK--------KLSLTQLIDSYGLEDQLLHYN 223
gi 1040197350 218 -E-ENK--------KLSLTQLVDHYGLDDKLIHYN 242
gi 514470931  196 -A-ENK--------KLSLTQLIDYHGLDDQLLHYN 220
gi 731466913  198 -E-ENK--------KLSLTELIDYYGLDDKLLHYN 222
gi 972972051  201 -T-DGR--------QLSLTQLIDHYGLDDRILHYN 225
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap