Conserved Protein Domain Family
Cluap1

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pfam10234: Cluap1 
Clusterin-associated protein-1
This protein is conserved from worms to humans. The protein of 413 amino acids contains a central coiled-coil domain, possibly the region that binds to clusterin. Cluap1 expression is highest in the nucleus and gradually increases during late S to G2/M phases of the cell cycle and returns to the basal level in the G0/G1 phases. In addition, it is upregulated in colon cancer tissues compared to corresponding non-cancerous mucosa. It thus plays a crucial role in the life of the cell.
Statistics
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PSSM-Id: 313461
View PSSM: pfam10234
Aligned: 46 rows
Threshold Bit Score: 223.982
Threshold Setting Gi: 820695730
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q16GM2        19 PnnIPLSVLNTPyggpeSFKAYYDVLTWLIGRLEPNLILA-GGIRSEQDRVLFVRSATEFLVTKSSIKVNPRKLYASSAA 97  yellow fever mo...
Q57WZ2        19 PnlISMESFRNP-----NVELVADCLFWLIKRYEPSAEIV-YEIEREADRVFFFKQVCEVALAKGRVKLNIKKLYQSDGN 92  Trypanosoma brucei
Q6I6D4        19 PrlMSIENFRTP-----NFQLVAELLEWIVKKFEPESNLDaHEVQTEADRVAFIKNAVLLMLQNSRIKMNPKKLYQADGH 93  Caenorhabditis ...
XP_001697203  19 PrlISMENFRVP-----NFELVADCLYWLVHRYYPGVEIA-DDISTESDRVKFLQSVAQVMLTKARMKLNIKRLYAADGN 92  Chlamydomonas r...
XP_010699716   7 PrlISMESFREP-----NVELVADCLHWLIIRYEPSAEVT-FNIEREHNRVTFFKQVCEVTLAKGRIKLNVKKLYQADGH 80  Leishmania pana...
XP_003055032  19 PriVSVENFRTP-----NFELVADCLEWLAQRYDGGAVVE-DDISTETDRVRFLKSVAAVFLSKARIKLNLKRLYAADGL 92  Micromonas pusi...
XP_002972098  12 gdgLSMESFRTP-----HFDTVASCMRWLLPRYDPEVQLH-GDVSTEEGRIAFLKSAGRFMFLKTRMKLNLRSLYMADSN 85  Selaginella moe...
KRX15442       7 PkfISIESFYKP-----NFLLVADALRWICKRYCDEQEVK-FELETEQDRVIFIKSAVIFIYQQTGLKLNPKKLYQADVE 80  Trichinella nel...
XP_001706997  19 PrpISIDTFRKP-----DFFLVAEILHYITTVVAPSNAIA-MDIATQEDRVYFITTVVNVLQTTLHLKLDSKKIYAAGPE 92  Giardia lamblia...
XP_001579632  19 PhpVGIDSFDTP-----NFGLMANLLHWLATLYDPEIVIL-AELSNEHGRVEFVRGIVQQMAIKSGIRLNPRKLYASDRF 92  Trichomonas vag...
Q16GM2        98 AAKELLKVTSLLIASPKVT----------GADEESIKsh--vEIDLSDKMDDLKKV-----------RGLSSELTNRGAA 154 yellow fever mo...
Q57WZ2        93 AVQEMLILANVLKKAMNTT----------GLEEIDHAtl--qQVIAQRNVQDAKRV-----------QQLCSDLTNDGSS 149 Trypanosoma brucei
Q6I6D4        94 AVQELLPAMKILYQAKAEDp---------NTDNSPKWtq--vKNKLSSKMQEVRIT-----------RQLSSQLPETGAL 151 Caenorhabditis ...
XP_001697203  93 AVKELLKLASLLYKA--TSk--------aGDMDDDAAea--iDVANSLKGFNPKEI-----------KGLAAEIIKAGAG 149 Chlamydomonas r...
XP_010699716  81 AVQEMLKLANVLKKAMKAT----------DAEEPDFTal--hQMAAQKNVSDAKAV-----------QQLCSELTTDGSS 137 Leishmania pana...
XP_003055032  93 AVKELLKIANLLYQATAKAd--------eDDADEEASgg--tAFALDASAFDVKTT-----------RALASEITRLGAT 151 Micromonas pusi...
XP_002972098  86 ATAELLQVSTLLEQAIASAs--------sEKVCENFVfl--fLTTLFKRAFDVKAA-----------RSLVLEIIKAGAT 144 Selaginella moe...
KRX15442      81 AIDELLKAVEPLYKAKKLNnmsegkrdddQQQQNIQFkq--iRTTLEQKLSDLGQY-----------HTMVNDITDNAAR 147 Trichinella nel...
XP_001706997  93 AVRELRKIVQEVATYIGAA-----------ATSTDKGtssaaSVDLTLHSNALCVA--------------SSKIVEASTK 147 Giardia lamblia...
XP_001579632  93 AVRELLKIAVPIYRGISSS----------------------------GRLADTKTTsfpknqntqkiSQLSATVPRHSVE 144 Trichomonas vag...
Q16GM2       155 LYDLLKKEL-VNRETRMVQSTRPLELATVEKVIKSAITSLDSKLVASKASLESLKAENGnltakiqrksSELERSKQRLQ 233 yellow fever mo...
Q57WZ2       150 LFFLIEEET-GQRGERQRVLSRATEVGEFERRLREVLKDVTTQVEQLQASIANLSADETtleqkieskkTQLERTQKRLK 228 Trypanosoma brucei
Q6I6D4       152 LSELLSRQE-FISQQHERAASRAVPLAEAEKVLQATVQNIAQETEQLSNKLNNVASDEAeldekierkkREYEQLQKRFA 230 Caenorhabditis ...
XP_001697203 150 LYDALGQEP-ELREHRARAVAGHVDTDFVERSIREAIAQVEDNIRSLENQMEDLERNEKtldnkiekkkQELERQEKRLS 228 Chlamydomonas r...
XP_010699716 138 LFFLVEAEL-NSRGDRQRILSRATEVGEFERRLRELLTNVAQEVDQYQQSIVNLSADETnleqkienkkAHLERAQKQYK 216 Leishmania pana...
XP_003055032 152 LHDALGEEE-RLRDARLSATRKNMDIEEIESQISEQIATVRENAANVERAMAELTEDESslarqierkrAELERSEKRLA 230 Micromonas pusi...
XP_002972098 145 LYDDLATEM-QLQGERNMAASTNTDIEQIENLVREGTDSLLQTVSSVEQQQHSCEKDEKslsithekrkVELERCKKRLS 223 Selaginella moe...
KRX15442     148 LYDLLSQET-ENKEQRTVALARQVDIDEVENHVKHALSLLQQELKQTSKDMENIEKDELavtskiekkkSELDRLQTRLA 226 Trichinella nel...
XP_001706997 148 LLTQLRLHVdDLYQRMQQAMSSQPDAASLSAAVQQRIKNLAAECNTLQEEVTTNKREKAkleeqitqkkQSITHTMDRLD 227 Giardia lamblia...
XP_001579632 145 LYDQLDKEV-QIRETRTKILSTVPSLDEVEKSVLESVDGAAARLEQLTKELDRLNSDEDalntkikqrkHEYERQSKRLM 223 Trichomonas vag...
Q16GM2       234 ALQ------------KVRPAYLEEFEKLELELKNLYEQYIIRIRCVDALKSQLISKN-RT 280 yellow fever mosquito
Q57WZ2       229 SLN------------AVRPAFMEEYEKHEGDMHSQFVIYLEQYRNLEYLEHELAKFN-AA 275 Trypanosoma brucei
Q6I6D4       231 KLQ------------SFRPQYMDEYERFEERLKKLYEVYVLNFRNLSYLRKVHDDLA-RS 277 Caenorhabditis elegans
XP_001697203 229 TLQ------------SVRPAYMDEYERLQGELNGLYQSYLDRFRNLEFLENELEAYY-QA 275 Chlamydomonas reinhardtii
XP_010699716 217 SAM------------ATNPAFLKEYENHEKKLQAQFVNYLEQYRNLEFLEHQIAKYNake 264 Leishmania panamensis
XP_003055032 231 TLEsgafytkvfhppSVRPAYMDEYERLEPEMDELHAAYIERHRNLTYLESELEKIE-Rd 289 Micromonas pusilla CCMP1545
XP_002972098 224 VLE------------NVRPAYLDEYEVLQSELQRLFGVYLEKFHNLRWLESQLETHN-Qe 270 Selaginella moellendorffii
KRX15442     227 QLQ------------TVRPAYMDEYETAEEELRRIYSQYVLKYRNLHYCKQLLkrdkqqq 274 Trichinella nelsoni
XP_001706997 228 AIR------------STKPPFLAELEALEADLSKLHLEYARKFRSLLFLEGQLRAND-VR 274 Giardia lamblia ATCC 50803
XP_001579632 224 SVQ------------TIRPAYMEEYEMLEQELGELFKTYFQHYRNVDYFEKEISKQAeKV 271 Trichomonas vaginalis G3
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